DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MCU and Mcu

DIOPT Version :9

Sequence 1:	NP_001246647.1	Gene:	MCU / 59223	FlyBaseID:	FBgn0042185	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_001028431.2	Gene:	Mcu / 215999	MGIID:	3026965	Length:	350	Species:	Mus musculus

Alignment Length:	280	Identity:	137/280 - (48%)
Similarity:	197/280 - (70%)	Gaps:	0/280 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 NEDIYVEYVNGMPHMTVRLPSRNELCQFALKPISHNVGDLLAMLRAEDRGIDRAAVINKHGVRIA 226
            ::|:.|.|.||:|.::||||||.|.|||.|||||.:||..|..|:.|||||||.|:.:..|||:|
Mouse    71 SDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVA 135

  Fly   227 SSCTIESLLDDSFSIQINNRTLDVNPPKRDKVTLESMDKVGDVRKVIAQLYEAFNVGEYQLEKSN 291
            :|..|:.||.|.|.:.||:.|..|.|||||.::.|....:.||:.::.|||....:.::||.|..
Mouse   136 ASTGIDLLLLDDFKLVINDLTYHVRPPKRDLLSHEDAATLNDVKTLVQQLYTTLCIEQHQLNKER 200

  Fly   292 QLAKELETLRYELEPLEEKKLELSKKAARRTNFMTWMGLGLMSVQFGILARLTWWEYSWDIMEPV 356
            :|.:.||.|:.:|.|||:.::|:|:||.:||..:.|.||..|:.|||||||||||||||||||||
Mouse   201 ELVERLEDLKQQLAPLEKVRIEISRKAEKRTTLVLWGGLAYMATQFGILARLTWWEYSWDIMEPV 265

  Fly   357 TYFVTYGTTMAMYAYYCVTKREYMMEDVKNREFSLSLYRNAKKVQFDVEHYNELKRKSAELEYNL 421
            |||:|||:.||||||:.:|::||:..:.::|::.|..::.|||.:||:|.||:||...|:.|.:|
Mouse   266 TYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQLKDAIAQAEMDL 330

  Fly   422 RRINDPLNMQLPSHLVRTQE 441
            :|:.|||.:.||...:..:|
Mouse   331 KRLRDPLQVHLPLRQIGEKE 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MCU	NP_001246647.1	MCU	208..410	CDD:282525	100/201 (50%)
Mcu	NP_001028431.2	N-terminal MCU domain. /evidence=ECO:0000250\|UniProtKB:Q8NE86	74..164		48/89 (54%)
		MCU	116..319	CDD:282525	100/202 (50%)
		Outer juxtamembrane helix (OJMH). /evidence=ECO:0000250\|UniProtKB:Q21121	215..233		9/17 (53%)
		DXXE. /evidence=ECO:0000250\|UniProtKB:Q21121	260..263		2/2 (100%)
		Inner juxtamembrane helix (IJMH). /evidence=ECO:0000250\|UniProtKB:Q21121	282..291		3/8 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848449
Domainoid	1	1.000	221	1.000	Domainoid score	I2594
eggNOG	1	0.900	-	-		E1_KOG2966
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9916
Inparanoid	1	1.050	290	1.000	Inparanoid score	I2788
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48647
OrthoDB	1	1.010	-	-		D1076768at2759
OrthoFinder	1	1.000	-	-		FOG0004164
OrthoInspector	1	1.000	-	-		oto94386
orthoMCL	1	0.900	-	-		OOG6_105346
Panther	1	1.100	-	-	LDO	PTHR13462
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1219
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770