Protein Alignment MCU and Mcu

DIOPT Version :10

• Sequence 1: NP_001246647.1
• Gene: MCU / 59223
• FlyBaseID: FBgn0042185
• Length: 457
• Species: Drosophila melanogaster
• Sequence 2: NP_001028431.2
• Gene: Mcu / 215999
• MGIID: 3026965
• Length: 350
• Species: Mus musculus
• Alignment Length: 280
• Identity: 137/280 - (48%)
• Similarity: 197/280 - (70%)
• Gaps: 0/280 - (0%)

  Fly   162 NEDIYVEYVNGMPHMTVRLPSRNELCQFALKPISHNVGDLLAMLRAEDRGIDRAAVINKHGVRIA 226
            ::|:.|.|.||:|.::||||||.|.|||.|||||.:||..|..|:.|||||||.|:.:..|||:|
Mouse    71 SDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVA 135

  Fly   227 SSCTIESLLDDSFSIQINNRTLDVNPPKRDKVTLESMDKVGDVRKVIAQLYEAFNVGEYQLEKSN 291
            :|..|:.||.|.|.:.||:.|..|.|||||.::.|....:.||:.::.|||....:.::||.|..
Mouse   136 ASTGIDLLLLDDFKLVINDLTYHVRPPKRDLLSHEDAATLNDVKTLVQQLYTTLCIEQHQLNKER 200

  Fly   292 QLAKELETLRYELEPLEEKKLELSKKAARRTNFMTWMGLGLMSVQFGILARLTWWEYSWDIMEPV 356
            :|.:.||.|:.:|.|||:.::|:|:||.:||..:.|.||..|:.|||||||||||||||||||||
Mouse   201 ELVERLEDLKQQLAPLEKVRIEISRKAEKRTTLVLWGGLAYMATQFGILARLTWWEYSWDIMEPV 265

  Fly   357 TYFVTYGTTMAMYAYYCVTKREYMMEDVKNREFSLSLYRNAKKVQFDVEHYNELKRKSAELEYNL 421
            |||:|||:.||||||:.:|::||:..:.::|::.|..::.|||.:||:|.||:||...|:.|.:|
Mouse   266 TYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQLKDAIAQAEMDL 330

  Fly   422 RRINDPLNMQLPSHLVRTQE 441
            :|:.|||.:.||...:..:|
Mouse   331 KRLRDPLQVHLPLRQIGEKE 350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MCU	NP_001246647.1	MCU	208..410	CDD:461389	100/201 (50%)
Mcu	NP_001028431.2	N-terminal MCU domain. /evidence=ECO:0000250|UniProtKB:Q8NE86	74..164		48/89 (54%)
		MCU	117..319	CDD:461389	100/201 (50%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:Q8NE86	259..267		7/7 (100%)
		Juxtamembrane helix. /evidence=ECO:0000250|UniProtKB:Q8NE86	284..289		2/4 (50%)