Protein Alignment Ugt305A1 and UGT2A3

DIOPT Version :10

• Sequence 1: NP_652703.1
• Gene: Ugt305A1 / 59217
• FlyBaseID: FBgn0042179
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: XP_011530549.1
• Gene: UGT2A3 / 79799
• HGNCID: 28528
• Length: 533
• Species: Homo sapiens
• Alignment Length: 590
• Identity: 135/590 - (22%)
• Similarity: 226/590 - (38%)
• Gaps: 142/590 - (24%)

  Fly     9 VFVLLGRFC--SLEAANILCLVSTAKHNNPGW--SKPLFDALLANGHSLLVIS-TAPNPEPKKQV 68
            ||:||..||  ......:|.......|    |  .|.:.:.|:..||.:.|:: :.|:....::.
Human     9 VFLLLQLFCVGCGFCGKVLVWPCDMSH----WLNVKVILEELIVRGHEVTVLTHSKPSLIDYRKP 69

  Fly    69 DGLVY--YHLP------NEYDVMKRHFLLEEPREYISMVTLNQLLVWYEV---LLGSCRALLNSD 122
            ..|.:  .|:|      ||..|.....:|.....:.|::.||...|  |:   |...|.:.:.:.
Human    70 SALKFEVVHMPQDRTEENEIFVDLALNVLPGLSTWQSVIKLNDFFV--EIRGTLKMMCESFIYNQ 132

  Fly   123 TMSSKRPELTAQLSMEYDLIITDVTQGIECLMDSVSGWRSKPVLGLSAGKLTPDLMSL-----LR 182
            |:..|..|      ..||:::.|                  ||  :..|.|..:|:::     ||
Human   133 TLMKKLQE------TNYDVMLID------------------PV--IPCGDLMAELLAVPFVLTLR 171

  Fly   183 AENTINAAR----IPHYISQVP-------KTMGFWNRLHNHIM-------------YYAEPLIHL 223
            .....|..|    :|..:|.||       ..|.|..|:.|.::             ::.|.....
Human   172 ISVGGNMERSCGKLPAPLSYVPVPMTGLTDRMTFLERVKNSMLSVLFHFWIQDYDYHFWEEFYSK 236

  Fly   224 VITRPVLSELMKTENAFPKLQLVLLNTHPTLDYVQNLPPGVIEVGGLHIKNQTSPLPT---YIQE 285
            .:.||  :.|.:|..   |.::.|:.|:...::.|...|....|||||.| ....||.   |:||
Human   237 ALGRP--TTLCETVG---KAEIWLIRTYWDFEFPQPYQPNFEFVGGLHCK-PAKALPKINFYLQE 295

  Fly   286 FTEKFF-----DGIVYINMPYIEYMNDQGLKAMYTMIHGNPNVAFIWNVEQLEQLP--------A 337
            . |.|.     ||||..::..: :.|....||         |:.    ...|.|:|        .
Human   296 M-ENFVQSSGEDGIVVFSLGSL-FQNVTEEKA---------NII----ASALAQIPQKVLWRYKG 345

  Fly   338 KKPNLLTLHVNQSL-----QQDILAMQYVKGFLNHGDSFSLQEAIHYGVPVVVLPLKLEEFNNAQ 397
            |||:  ||..|..|     |.|:|.....|.|:.||....:.|||::|||:|.:|:..::.:|..
Human   346 KKPS--TLGANTRLYDWIPQNDLLGHPKTKAFITHGGMNGIYEAIYHGVPMVGVPIFGDQLDNIA 408

  Fly   398 RVMERNLGVMLQVKEFNQSSLSDALTRILDEERF------ISALHQAQLKFRTRPQSALELAVWH 456
            .:..:...|.:..|......|..||..::.:..:      :|.:|..|      |...|:.||:.
Human   409 HMKAKGAAVEINFKTMTSEDLLRALRTVITDSSYKENAMRLSRIHHDQ------PVKPLDRAVFW 467

  Fly   457 AEQLIAEPRLFKHF---AQTETLAQNFFVANSLDVLTVPLIVLLAAVVSLANLVYVLYTGGSKRQ 518
            .| .:...:..||.   |...|..|::    |:||:.. |:..:|..:.|....::.......:.
Human   468 IE-FVMRHKGAKHLRSAAHDLTWFQHY----SIDVIGF-LLACVATAIFLFTKCFLFSCQKFNKT 526

  Fly   519 QTLEK 523
            :.:||
Human   527 RKIEK 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_652703.1	GT1_Gtf-like	22..460	CDD:340817	116/507 (23%)
UGT2A3	XP_011530549.1	UDPGT	24..528	CDD:278624	127/570 (22%)