DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt305A1 and ugt2a6

DIOPT Version :9

Sequence 1:	NP_001261394.1	Gene:	Ugt305A1 / 59217	FlyBaseID:	FBgn0042179	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001138283.1	Gene:	ugt2a6 / 797211	ZFINID:	ZDB-GENE-081104-3	Length:	529	Species:	Danio rerio

Alignment Length:	581	Identity:	127/581 - (21%)
Similarity:	226/581 - (38%)	Gaps:	128/581 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ILCLVSTAKHNNPGWS----------------KPLFDALLANGHSLLVISTAPNPE-PKKQVDGL 71
            :||.|..      |||                :|:.:||:...||:.|:..:.:|. |..|.:..
Zfish    11 LLCGVDV------GWSGRVLVMPGEYSHWHNMRPVIEALVDKNHSVTVLVGSSSPTVPHTQKERF 69

  Fly    72 VYYHLPNEYDVMKRHFLLEEPREYISM----VTLNQLLVWYEVLLGSCRALLNSDTMSSKRPELT 132
                   ||.|.|.: :.:|..:|:.:    :.:|:.:..||..|...:.:   ....:...||.
Zfish    70 -------EYHVFKVN-MEKEVVDYLWIHFHELWMNETISTYEKTLEVWQLM---SLFRAHSEELV 123

  Fly   133 AQL----------SMEYDLIITDVTQGIECLMDSVSGWRSKPVLGLSAGKLT-PDLMSL------ 180
            ..|          ...||::.:|:|.               |...|.|.||. |.::|:
Zfish   124 KGLFDVGLLKTLRDSNYDVLFSDLTM---------------PFSDLMAQKLNIPHVLSMRISFAS 173

  Fly   181 ----LRAENTINAARIPHYISQ--VPKTMGFWNRLHNHIMYYAEPLIHLVITRPVLSELMKTENA 239
                |..:..:..:.:|..::|  :...|.|..|:.|.::|.....:..:.|:.....:....:.
Zfish   174 ALERLCGQMPVPQSYVPAAVAQGHLTDRMSFTERVENMLLYITHTAMFQLTTKFTFDHIYAEISG 238

  Fly   240 FP--------KLQLVLLNTHPTLDYVQNLPPGVIEVGGLHIKNQTSPLPTYIQEFTEKFFD-GIV 295
            .|        |..:.|:.|:...:|.:..||....||||..| ...||...::||.:...| |||
Zfish   239 EPTTMCETIGKTDIWLIRTYWDFEYPRPFPPNFKFVGGLQCK-PAKPLAKELEEFVQSSGDHGIV 302

  Fly   296 YINM-PYIEYMNDQGLKAMYTMIHGNPNVAFIWNVEQLEQLPAKKPNLLTLHVNQSL-----QQD 354
            ..:: ..|:.:..|....:...: |..:...:|      :...|.|.  ||..|..:     |.|
Zfish   303 VFSLGSMIKNLTVQKANTIAAAL-GQISQKVVW------RYSGKTPE--TLAPNTKIYDWIPQND 358

  Fly   355 ILAMQYVKGFLNHGDSFSLQEAIHYGVPVVVLPLKLEEFNNAQRVMERNLGVMLQVKEFNQSSLS 419
            :|.....|.|:.||.:..|.|||::|||:|.|||..::.:|...:..:...|:|.........|.
Zfish   359 LLGHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLFGDQPDNLMHLKSKGAAVVLDFFTLESKDLV 423

  Fly   420 DALTRILDEERF------ISALHQAQLKFRTRPQSALELAVWHAEQLIAEPRLFKHF-AQTETLA 477
            |||..:|:...:      :|.:|..|      |...|:.||:..| .:...:..||. .|...|
Zfish   424 DALKTVLNNPSYKESIMRLSRIHHDQ------PMKPLDQAVYWIE-FVMRNKGAKHLRVQAHEL- 480

  Fly   478 QNFFVANSLDVLTVPLIVLLAAVVSLANLVYVLYTGGSKRQQTLEKAVLKKRKKSKKSSPQ 538
             :::..:.|||        .|.::|:..|:..|:.   |....|.:..::|.:..:||..:
Zfish   481 -SWYQYHCLDV--------AAFLLSITALITFLWV---KACCFLFRRCVRKTRPERKSKKE 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	62/231 (27%)
ugt2a6	NP_001138283.1	UDPGT	21..519	CDD:278624	118/553 (21%)
ugt2a6	NP_001138283.1	egt	<254..485	CDD:223071	65/249 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585074
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930