Protein Alignment Ugt305A1 and UGT2B17

DIOPT Version :9

• Sequence 1: NP_001261394.1
• Gene: Ugt305A1 / 59217
• FlyBaseID: FBgn0042179
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_001068.1
• Gene: UGT2B17 / 7367
• HGNCID: 12547
• Length: 530
• Species: Homo sapiens
• Alignment Length: 609
• Identity: 129/609 - (21%)
• Similarity: 238/609 - (39%)
• Gaps: 166/609 - (27%)

  Fly     7 LPVFVLLGRFCSLEAANILC---LVSTAKHNNPGW--SKPLFDALLANGHSLLVISTAP----NP 62
            :.||:|:...|...:.:  |   ||...::::  |  .|.:.:.|:..||.::|::::.    |.
Human     6 MSVFLLMQLSCYFSSGS--CGKVLVWPTEYSH--WINMKTILEELVQRGHEVIVLTSSASILVNA 66

  Fly    63 EPKKQVDGLVYYHLPNE------------------YDVMKRHFLLEEPREYISMVTLNQLLVW-- 107
            .....:...||   |..                  |.:.|..|.     .|.|.:   |.|.|
Human    67 SKSSAIKLEVY---PTSLTKNDLEDFFMKMFDRWTYSISKNTFW-----SYFSQL---QELCWEY 120

  Fly   108 --YEVLLGSCR-ALLNSDTMSSKRPELTAQLSMEYDLIITDVTQGIECLMDSVSGWRSKPVLGLS 169
              |.:.|  |. |:||...|...:       ..::|:::.|...                    .
Human   121 SDYNIKL--CEDAVLNKKLMRKLQ-------ESKFDVLLADAVN--------------------P 156

  Fly   170 AGKLTPDLMSL-----LRAENTINAAR-----------IPHYISQVPKTMGFWNRLHNHI----- 213
            .|:|..:|:::     ||........:           :|..:|::...|.|..|:.|.|
Human   157 CGELLAELLNIPFLYSLRFSVGYTVEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIYMLYF 221

  Fly   214 -------------MYYAEPLIHLVITRPVLSELMKTENAFPKLQLVLLNTHPTLDYVQNLPPGVI 265
                         .:|:|     |:.||  :.|.:|   ..|.::.|:.|:...::.:...|.|.
Human   222 DFWFQAYDLKKWDQFYSE-----VLGRP--TTLFET---MGKAEMWLIRTYWDFEFPRPFLPNVD 276

  Fly   266 EVGGLHIKNQTSPLPTYIQEFTEKFFD-GIVYINM-PYIEYMNDQGLKAMYTMIHGNPNVAFIWN 328
            .|||||.| ...|||..::||.:...: |||..:: ..|..|:::....:.:.:...|. ..:|.
Human   277 FVGGLHCK-PAKPLPKEMEEFVQSSGENGIVVFSLGSMISNMSEESANMIASALAQIPQ-KVLWR 339

  Fly   329 VEQLEQLPAKKPNLLTLHVNQSL-----QQDILAMQYVKGFLNHGDSFSLQEAIHYGVPVVVLPL 388
            .:      .||||  ||..|..|     |.|:|.....|.|:.||.:..:.|||::|:|:|.:||
Human   340 FD------GKKPN--TLGSNTRLYKWLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPL 396

  Fly   389 KLEEFNNAQRVMERNLGVMLQVKEFNQSSLSDALTRILDEERF------ISALHQAQLKFRTRPQ 447
            ..::.:|...:..:...:.:.::..:...|.:||..::::..:      :|.:|..|      |.
Human   397 FADQHDNIAHMKAKGAALSVDIRTMSSRDLLNALKSVINDPIYKENIMKLSRIHHDQ------PV 455

  Fly   448 SALELAVWHAEQLIAEPRLFKHFAQTETLAQN--FFVANSLDVLTVPLIVLLAAVVSLANLVYVL 510
            ..|:.||:..| .:...:..||.   ...|.|  :...:||||:.    .|||.|   |.:::::
Human   456 KPLDRAVFWIE-FVMRHKGAKHL---RVAAHNLTWIQYHSLDVIA----FLLACV---ATMIFMI 509

  Fly   511 YTGGSKRQQTLEKAVLKKRKKSKK 534
                :|......:.:.|..||.|:
Human   510 ----TKCCLFCFRKLAKTGKKKKR 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	58/231 (25%)
UGT2B17	NP_001068.1	UDPGT	24..518	CDD:278624	120/576 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150276
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940