Protein Alignment Ugt305A1 and UGT2B15

DIOPT Version :9

• Sequence 1: NP_001261394.1
• Gene: Ugt305A1 / 59217
• FlyBaseID: FBgn0042179
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_001067.2
• Gene: UGT2B15 / 7366
• HGNCID: 12546
• Length: 530
• Species: Homo sapiens
• Alignment Length: 602
• Identity: 135/602 - (22%)
• Similarity: 241/602 - (40%)
• Gaps: 156/602 - (25%)

  Fly     9 VFVLLGRFCSLEAANILC---LVSTAKHNNPGW--SKPLFDALLANGHSLLVI----STAPNPEP 64
            ||:|:...|...:.:  |   ||...::::  |  .|.:.:.|:..||.:.|:    ||..|...
Human     8 VFLLIQLSCYFSSGS--CGKVLVWPTEYSH--WINMKTILEELVQRGHEVTVLTSSASTLVNASK 68

  Fly    65 KKQVDGLVY------YHLPNE---------YDVMKRHFLLEEPREYISMVTLNQLLVW--YEVLL 112
            ...:...||      .:|.:.         |.|.|..|.     .|.|.:   |.|.|  |:...
Human    69 SSAIKLEVYPTSLTKNYLEDSLLKILDRWIYGVSKNTFW-----SYFSQL---QELCWEYYDYSN 125

  Fly   113 GSCR-ALLNSDTMSSKRPELTAQLSMEYDLIITDVTQGIECLMDSVSGWRSKPVLGLSAGKLTPD 176
            ..|: |:||...|...:       ..::|:|:.|...                    ..|:|..:
Human   126 KLCKDAVLNKKLMMKLQ-------ESKFDVILADALN--------------------PCGELLAE 163

  Fly   177 LMSL-----LR-------AEN----TINAARIPHYISQVPKTMGFWNRLHN--HIMY-------- 215
            |.::     ||       .:|    ....:.:|..:|::...|.|..|:.|  |::|
Human   164 LFNIPFLYSLRFSVGYTFEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIHMLYFDFWFQIY 228

  Fly   216 --------YAEPLIHLVITRPVLSELMKTENAFPKLQLVLLNTHPTLDYVQNLPPGVIEVGGLHI 272
                    |:|     |:.||  :.|.:|   ..|.::.|:.|:...::.:...|.|..|||||.
Human   229 DLKKWDQFYSE-----VLGRP--TTLFET---MGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHC 283

  Fly   273 KNQTSPLPTYIQEFTEKFFD-GIVYINM-PYIEYMNDQGLKAMYTMIHGNPNVAFIWNVEQLEQL 335
            | ...|||..::||.:...: |||..:: ..|..|:::....:.:.:...|. ..:|..:
Human   284 K-PAKPLPKEMEEFVQSSGENGIVVFSLGSMISNMSEESANMIASALAQIPQ-KVLWRFD----- 341

  Fly   336 PAKKPNLLTLHVNQSL-----QQDILAMQYVKGFLNHGDSFSLQEAIHYGVPVVVLPLKLEEFNN 395
             .||||  ||..|..|     |.|:|.....|.|:.||.:..:.|||::|:|:|.:||..::.:|
Human   342 -GKKPN--TLGSNTRLYKWLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDN 403

  Fly   396 AQRVMERNLGVMLQVKEFNQSSLSDALTRILDEERF------ISALHQAQLKFRTRPQSALELAV 454
            ...:..:...:.:.::..:...|.:||..::::..:      :|.:|..|      |...|:.||
Human   404 IAHMKAKGAALSVDIRTMSSRDLLNALKSVINDPVYKENVMKLSRIHHDQ------PMKPLDRAV 462

  Fly   455 WHAEQLIAEPRLFKHFAQTETLAQN--FFVANSLDVLTVPLIVLLAAVVSLANLVYVLYTGGSKR 517
            :..| .:...:..||.   ...|.|  :...:||||:.    .|||.|   |.:::::    :|.
Human   463 FWIE-FVMRHKGAKHL---RVAAHNLTWIQYHSLDVIA----FLLACV---ATVIFII----TKF 512

  Fly   518 QQTLEKAVLKKRKKSKK 534
            .....:.:.||.||.|:
Human   513 CLFCFRKLAKKGKKKKR 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	58/231 (25%)
UGT2B15	NP_001067.2	egt	8..508	CDD:223071	129/575 (22%)
		UDPGT	24..518	CDD:278624	125/571 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150300
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940