Protein Alignment Ugt305A1 and UGT2B10

DIOPT Version :9

• Sequence 1: NP_001261394.1
• Gene: Ugt305A1 / 59217
• FlyBaseID: FBgn0042179
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_001066.1
• Gene: UGT2B10 / 7365
• HGNCID: 12544
• Length: 528
• Species: Homo sapiens
• Alignment Length: 556
• Identity: 116/556 - (20%)
• Similarity: 213/556 - (38%)
• Gaps: 153/556 - (27%)

  Fly    42 LFDALLANGHSLLVISTAPNPEPKKQVDGLVYYHLPNEYDVMKRHFLLEEPREYISMVTLNQLLV 106
            |||   .|..|.|.:...|....|.:.:.::...:....::.|..|.|...:|        |.::
Human    62 LFD---PNDSSTLKLEVYPTSLTKTEFENIIMQLVKRLSEIQKDTFWLPFSQE--------QEIL 115

  Fly   107 W--YEVLLGSCRALLNSDTMSSKRPELTAQLSMEYDLIITDVTQGIECLMDSVSGWRSKPVLGLS 169
            |  .:::...|:.::::..:..|..|      ..:|::..|..                    |.
Human   116 WAINDIIRNFCKDVVSNKKLMKKLQE------SRFDIVFADAY--------------------LP 154

  Fly   170 AGKLTPDLMSLLRAEN----------------TINAARIPHYISQVPKTMGFWNRLHN--HIMY- 215
            .|:|..:|.::....:                ....:.:|..:|::...|.|..|:.|  :::|
Human   155 CGELLAELFNIPFVYSHSFSPGYSFERHSGGFIFPPSYVPVVMSKLSDQMTFMERVKNMLYVLYF 219

  Fly   216 ---------------YAEPLIHLVITRP-VLSELMKTENAFPKLQLVLLNT-------HPTLDYV 257
                           |:|     |:.|| .|||.|:      |..:.|:..       ||.|
Human   220 DFWFQIFNMKKWDQFYSE-----VLGRPTTLSETMR------KADIWLMRNSWNFKFPHPFL--- 270

  Fly   258 QNLPPGVIEVGGLHIKNQTSPLPTYIQEFTEKFFD-GIVYINM-PYIEYMNDQGLKAMYTMIHGN 320
                |.|..|||||.| ...|||..::||.:...: |:|..:: ..:..|.::....:.|.:...
Human   271 ----PNVDFVGGLHCK-PAKPLPKEMEEFVQSSGENGVVVFSLGSMVSNMTEERANVIATALAKI 330

  Fly   321 PNVAFIWNVEQLEQLPAKKPNLLTLHVNQSL-----QQDILAMQYVKGFLNHGDSFSLQEAIHYG 380
            |. ..:|..:      ..||:.|.|  |..|     |.|:|.....:.|:.||.:..:.|||::|
Human   331 PQ-KVLWRFD------GNKPDALGL--NTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHG 386

  Fly   381 VPVVVLPLKLEEFNNAQRVMERNLGVMLQVKEFNQSSLSDALTRILDEERF---ISALHQAQLKF 442
            :|:|.:||..::.:|...:..:...|.:.....:.:.|.:||..::::..:   |..|.:.|
Human   387 IPMVGIPLFFDQPDNIAHMKAKGAAVRVDFNTMSSTDLLNALKTVINDPSYKENIMKLSRIQ--- 448

  Fly   443 RTRPQSALELAVWHAEQLIAEPRLFKHFAQTETLAQN--FFVANSLDVLTVPLIVLLAAVVSLAN 505
            ..:|...|:.||:..| .:...:..||.   ...|.|  :|..:||||:.    .|||.|   |.
Human   449 HDQPVKPLDRAVFWIE-FVMRHKGAKHL---RVAAHNLTWFQYHSLDVIG----FLLACV---AT 502

  Fly   506 LVYVLYTGGSKRQQTLEKAVL-------KKRKKSKK 534
            ::::           :.|..|       :|.||.|:
Human   503 VLFI-----------ITKCCLFCFWKFARKGKKGKR 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	57/235 (24%)
UGT2B10	NP_001066.1	UDPGT	23..524	CDD:278624	113/551 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150544
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940