DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt305A1 and Ugt2b1

DIOPT Version :9

Sequence 1:	NP_001261394.1	Gene:	Ugt305A1 / 59217	FlyBaseID:	FBgn0042179	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_690024.1	Gene:	Ugt2b1 / 71773	MGIID:	1919023	Length:	529	Species:	Mus musculus

Alignment Length:	566	Identity:	122/566 - (21%)
Similarity:	224/566 - (39%)	Gaps:	136/566 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SLEAANILCLVSTAKHNNPG--------------W--SKPLFDALLANGHSLLV-ISTAP---NP 62
            |::.|::..|:....:..||              |  .|.:.|.|:..||.:.| ||:|.   .|
Mouse     2 SMKQASVFLLIQFICYIRPGACGKVLVWPTEYSHWINMKIILDELVQRGHDVTVLISSASILIGP 66

  Fly    63 EPKKQVDGLVYYHLPNEYDVMKRHFLLEEPREYISMVT--LNQLLVWYEVLLGSCRALLNSDTMS 125
            ..:..:: ...|..|...|.::..|     .:::...|  |.:|..|               |..
Mouse    67 SNESSIN-FEIYSAPLSKDDLEYAF-----EKWVGNWTYELKKLPFW---------------TSY 110

  Fly   126 SKRPELTAQLSMEYDLIITDVTQGI---ECLMDSVSGWRSKPVLGLSAGKLTP--DLMSLLRAEN 185
            ||    ..::|.||..:|....:.:   :.||..:.|.:...||   |..|.|  :|:|.|....
Mouse   111 SK----LQKISSEYSDMIESFCKAVVWNKSLMKKLQGSKFDVVL---ADALVPCGELLSELLKTP 168

  Fly   186 TINAAR--------------------IPHYISQVPKTMGFWNRLHNHI----------------- 213
            .:.:.|                    :|..:|::...|.|..|:.|.:
Mouse   169 LVYSLRFCPGYKCEKYSGGLPLPPSYVPVVLSELSDHMTFAERVKNMLQVLLFDFWFQTFNEKSW 233

  Fly   214 -MYYAEPLIHLVITRP-VLSELMKTENAFPKLQLVLLNTHPTLDYVQNLPPGVIEVGGLHIKNQT 276
             .:|::     |:.|| .|:|:|      .|..:.|:.|...|.:.....|....|||||.| ..
Mouse   234 NQFYSD-----VLGRPTTLTEMM------GKADIWLVRTFWDLKFPHPFLPNFDFVGGLHCK-PA 286

  Fly   277 SPLPTYIQEFTEKFFD-GIVYINM-PYIEYMNDQGLKAMYTMIHGNPNVAFIWNVEQLEQLPAKK 339
            .|||..::||.:...: |:|..:: ..::.:.::....:.:.:...|. ..:|..:      .||
Mouse   287 KPLPKEMEEFVQSSGEHGVVVFSLGSMVKNIKEEKANVVASALAQIPQ-KVLWRFD------GKK 344

  Fly   340 PNLLTLHVNQSL-----QQDILAMQYVKGFLNHGDSFSLQEAIHYGVPVVVLPLKLEEFNNAQRV 399
            |:  ||..|..|     |.|:|.....|.|:.||.:..:.|||::|:|:|.:||..::.:|...:
Mouse   345 PD--TLGSNTRLYKWIPQNDLLGHPKTKAFIAHGGTNGIYEAIYHGIPIVGIPLFGDQPDNINHI 407

  Fly   400 MERNLGVMLQVKEFNQSSLSDALTRILDEERF------ISALHQAQLKFRTRPQSALELAVWHAE 458
            :.:...|.:.....:.:.|..||..::::..:      :|.:|..|      |...|:.||:..|
Mouse   408 VAKGAAVRVDFDTMSTTDLLTALKTVINDPSYKENAMRLSRIHHDQ------PMKPLDRAVFWIE 466

  Fly   459 QLIAEPRLFKHFAQTETLAQNFFVANSLDVLTVPLIVLLAAVVSLA 504
            .::.. :..||. :.......:|..:||||:...|:.::|.|..:|
Mouse   467 YVMRN-KGAKHL-RPALHDLTWFQYHSLDVIGFLLVCVVAVVFIIA 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	55/231 (24%)
Ugt2b1	NP_690024.1	egt	8..508	CDD:223071	119/556 (21%)
Ugt2b1	NP_690024.1	UDPGT	24..527	CDD:278624	117/544 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840567
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48043
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.030