DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt305A1 and UGT2A2

DIOPT Version :9

Sequence 1:	NP_001261394.1	Gene:	Ugt305A1 / 59217	FlyBaseID:	FBgn0042179	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001099147.2	Gene:	UGT2A2 / 574537	HGNCID:	28183	Length:	536	Species:	Homo sapiens

Alignment Length:	546	Identity:	119/546 - (21%)
Similarity:	217/546 - (39%)	Gaps:	128/546 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 AANILCLVSTAKHNNPGW--SKPLFDALLANGHSLLVISTA------PNPE------------PK 65
            :.|:|...:...|    |  .|.:.:.|:...|::.|::::      .||:            .|
Human    29 SGNVLIWPTDGSH----WLNIKIILEELIQRNHNVTVLASSATLFINSNPDSPVNFEVIPVSYKK 89

  Fly    66 KQVDGLVYY-------HLPNEYDVMKRHFLLEEPREYISMVTLNQLL-VWYEVLLGSCRALLNSD 122
            ..:|.|:.:       |.|....:..  |..|          |.:|| .::::.:..|..:|
Human    90 SNIDSLIEHMIMLWIDHRPTPLTIWA--FYKE----------LGKLLDTFFQINIQLCDGVL--- 139

  Fly   123 TMSSKRPELTAQLSM-EYDLIITDVTQGIECLMDSVSGWRSKPVLGLSAGKLTPDLMSLLR--AE 184
                |.|:|.|:|.. .:|:::.|..        ::.|       .|.|.||....|..||  ..
Human   140 ----KNPKLMARLQKGGFDVLVADPV--------TICG-------DLVALKLGIPFMYTLRFSPA 185

  Fly   185 NTI--NAARIPHYISQVPKT-------MGFWNRLHNHIMYYAEPLI------------HLVITRP 228
            :|:  :..:||..:|.||..       |.|..|:.|.|.|..:..|            ..::.||
Human   186 STVERHCGKIPAPVSYVPAALSELTDQMTFGERIKNTISYSLQDYIFQSYWGEWNSYYSKILGRP 250

  Fly   229 -VLSELMKTENAFPKLQLVLLNTHPTLDYVQNLPPGVIEVGGLHIKNQTSPLPTYIQEFTEKF-F 291
             .|.|.|      .|.::.|:.|:...::.:...|....|||||.| ...|||..::||.:.. .
Human   251 TTLCETM------GKAEIWLIRTYWDFEFPRPYLPNFEFVGGLHCK-PAKPLPKEMEEFIQSSGK 308

  Fly   292 DGIVYINM-PYIEYMNDQGLKAMYTMIHGNPNVAFIWNVEQLEQLPAKKPNLLTLHVNQSL---- 351
            :|:|..:: ..::.:.::....:.:.:...|. ..:|..:      .|||  .||..|..|
Human   309 NGVVVFSLGSMVKNLTEEKANLIASALAQIPQ-KVLWRYK------GKKP--ATLGNNTQLFDWI 364

  Fly   352 -QQDILAMQYVKGFLNHGDSFSLQEAIHYGVPVVVLPLKLEEFNNAQRVMERNLGVMLQVKEFNQ 415
             |.|:|.....|.|:.||.:..:.|||::|||:|.:|:..::.:|...:..:...|.:.:.....
Human   365 PQNDLLGHPKTKAFITHGGTNGIYEAIYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTS 429

  Fly   416 SSLSDALTRILDEERF------ISALHQAQLKFRTRPQSALELAVWHAEQLIAEPRLFKHFAQTE 474
            ..|..||..:::|..:      :|.:|..|      |...|:.||:..| .:...:..||. :..
Human   430 VDLLSALRTVINEPSYKENAMRLSRIHHDQ------PVKPLDRAVFWIE-FVMRHKGAKHL-RVA 486

  Fly   475 TLAQNFFVANSLDVLTVPLIVLLAAV 500
            .....:|..:||||:...|:.:..|:
Human   487 AHDLTWFQYHSLDVIGFLLVCVTTAI 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	55/231 (24%)
UGT2A2	NP_001099147.2	UDPGT	30..524	CDD:278624	119/545 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150195
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940