DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt305A1 and ugt5c3

DIOPT Version :9

Sequence 1:	NP_001261394.1	Gene:	Ugt305A1 / 59217	FlyBaseID:	FBgn0042179	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001122186.1	Gene:	ugt5c3 / 563413	ZFINID:	ZDB-GENE-050419-23	Length:	531	Species:	Danio rerio

Alignment Length:	595	Identity:	129/595 - (21%)
Similarity:	238/595 - (40%)	Gaps:	150/595 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LCLLPVFV----LLGRFCSLEAANILCLVSTAKHNNPGWSKP--LFDALLANGHSLLVISTAPNP 62
            ||.:.:::    |.|..|  :...||.:.....|    |...  |..||...|||:.||....:.
Zfish     8 LCSVSLWITIIPLFGFLC--DGGKILVVPLEGSH----WLNMDILIKALHGKGHSIDVIRNTNSW 66

  Fly    63 EPKKQVDGLVYYH---------LPNEY--DVMKRHFLLEEPR-EYISMVTL--NQLLVWYEVLLG 113
            ..|::.|   ||:         :..|:  |::.:....|..: .::|.|.|  :.::..||:...
Zfish    67 YVKEKSD---YYNSITIPQSKGMDEEFVDDMISKVINHERGKSSWLSTVKLFFDSVIDNYEMTKM 128

  Fly   114 SCRALLNSDTMSSKRPELTAQLSMEYDLIITDVTQGIECLMDSVSGWRSKPVLGLS---AGKLTP 175
            .|.  :.:....|:....|.| ..:|||::||                  ||.|:.   |.||..
Zfish   129 VCD--ITTSIFESEEILKTLQ-EKQYDLMLTD------------------PVWGMGIILAHKLKL 172

  Fly   176 DLMSLLRAENTI----NAARIPHYISQVPKT-------MGFWNRLHNHIMYYAEPLIHLVITRPV 229
            .::..:|...|:    |.|  |..:|.:|.|       |.|:.|:.|.|.|:.
Zfish   173 PMVYNVRWTTTVDGHFNIA--PSPMSYIPITGSGNTDRMSFFQRVKNIIFYFT------------ 223

  Fly   230 LSELMKTENAFPKLQLVL-LNTHPTLDYVQNLP--------------------PGVIEVGGLHIK 273
             :::..:..:.|:.|.:. ....|.:|:.|.|.                    |.:|..||...
Zfish   224 -NDIKYSRFSLPQYQAICDKYFDPPVDFYQLLQGADIWLMRVDFVFEFPRPTMPNIIYTGGFQC- 286

  Fly   274 NQTSPLPTYIQEFTEKFFD-GIVYINMPYIEYMNDQGLKAMYTMIHGNPN-------VAF----- 325
            ....|||..:::|.:...| |::.:::.              |.|...|.       .||
Zfish   287 TPAKPLPHDLEDFMQSSGDHGVIVMSLG--------------TFISALPEDVTAEIAAAFARLPQ 337

  Fly   326 --IWNVEQLEQLPAKKPNLL---TLHVNQSLQQDILAMQYVKGFLNHGDSFSLQEAIHYGVPVVV 385
              ||      :...|||:.|   ||.|:...|:|:|.....|.|:.||.:..:|||:::|||||.
Zfish   338 KVIW------RYTGKKPSTLGNNTLLVDWMPQKDLLGHPKTKVFVAHGGTNGVQEALYHGVPVVG 396

  Fly   386 LPLKLEEFNNAQRVMERNLGVMLQVKEFNQSSLSDALTRILDEERFISALHQAQLKFRTRPQSAL 450
            :|...::::|..|:..|....::.:.|..::||..|:..:::...:...:.:.......:|...|
Zfish   397 IPFFFDQYDNLIRLQARGGAKIVSLAELGENSLHAAIKEVINNPSYRLTMQKLSQLHLDKPVKPL 461

  Fly   451 ELAVWHAEQLIAEPRLFKH----FAQTETLAQNFFVANSLDVLTVPLIVLLAAVVSLANLV-YVL 510
            :.|::..|.::      :|    ..:||:....::..:|:||....:.|:|..:.|:..:| ||.
Zfish   462 DSAIFWIEFVM------RHKGAAHLRTESYKMPWYSYHSVDVAVTLIAVVLIFIFSIFYVVRYVC 520

  Fly   511 YTGGSKRQQT 520
            ....|::::|
Zfish   521 IKCCSRKRKT 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	56/257 (22%)
ugt5c3	NP_001122186.1	UDPGT	28..530	CDD:278624	123/571 (22%)
ugt5c3	NP_001122186.1	egt	<267..507	CDD:223071	58/266 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585146
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.940