DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt305A1 and ugt5g2

DIOPT Version :9

Sequence 1:	NP_001261394.1	Gene:	Ugt305A1 / 59217	FlyBaseID:	FBgn0042179	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001186305.1	Gene:	ugt5g2 / 556049	ZFINID:	ZDB-GENE-081028-66	Length:	534	Species:	Danio rerio

Alignment Length:	576	Identity:	141/576 - (24%)
Similarity:	222/576 - (38%)	Gaps:	119/576 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CLLPVFVLLGRFCSL----EAANILCLVSTAKHNNPGW--SKPLFDALLANGHSLLVI------- 56
            |:..||:......||    .|..||.......|    |  .:.|...|.:.||.|.||
Zfish     4 CMSLVFLWTSLLLSLPSGYNADKILVFPIDGSH----WVNMEVLVKKLQSRGHELSVIRLEDSWF 64

  Fly    57 --------STAPNPEPKKQVDGLVYYHLPNEYDVMKRHFLLEEPREYISMVTLNQLLVWYEVLL- 112
                    |:......||.:|..::     |..|.|   :|:..|:...|..|.|:..:..:|.
Zfish    65 IKGNSPYYSSITVTLKKKFIDLDLF-----ETAVKK---ILDARRDGPIMGVLAQMSEFIGILKV 121

  Fly   113 --GSCRALLNSDTMSSKRPELTAQLSM-EYDLIITD--------VTQGIECLMDSVSGWRSKPVL 166
              |:..|:|.| .:.:|  .|.:|:.| .|||::||        :...:...|.....|.|   .
Zfish   122 GHGANIAMLTS-MLENK--VLMSQIKMANYDLMLTDPAMPGGVILAHYLHLPMVYNVRWMS---F 180

  Fly   167 GLSAGKLTPDLMSLLRAENTINAARIPHYISQVPKTMGFWNRLHNHIMYYAEPLIH---LVITRP 228
            |.....:.|..:|.           :|...|.:...||...|..| .::|...||.   :||  |
Zfish   181 GEGHFSIAPSPISF-----------VPVPGSGLTDRMGLLERSRN-FLHYGLNLIQERWMVI--P 231

  Fly   229 VLSELMKTENAFPK-LQLVLLNTHPTL-----DYVQNLP----PGVIEVGGLHIKNQTSPLPTYI 283
            :.:.|:.  |.||. ..|:.:.....|     |:|...|    |.::.:||...: ...|||..:
Zfish   232 MYTSLLL--NHFPPGTDLLTMQRSAELWLVRADFVFEFPRPSMPNLVYIGGFQCR-PAKPLPADL 293

  Fly   284 QEFTEKFFD-GIVYINMPYIEYMNDQGLKAMYTMIHGNPNVAFIWNVEQLEQLPAK--------K 339
            :||.:...| |:|.:::.              |:|.|.|............|:|.|        :
Zfish   294 EEFMQSSGDHGVVVMSLG--------------TLIAGLPKEVMEAIASAFAQIPQKVIWRFIGQR 344

  Fly   340 PNLL---TLHVNQSLQQDILAMQYVKGFLNHGDSFSLQEAIHYGVPVVVLPLKLEEFNNAQRVME 401
            |:.|   ||.:....|.|:|.....:.|:.||.:..|.|||::||||:.|||..::.:|..|:..
Zfish   345 PSTLGNNTLLIQWLPQNDLLGHPKTRAFVAHGGTNGLYEAIYHGVPVLGLPLLFDQLDNIVRLQA 409

  Fly   402 RNLGVMLQVKEFNQSSLSDALTRILDEERFISALHQAQLKFRTRPQSALELAVWHAEQLI---AE 463
            |....||.....:......|||.||:...:...:.:.....|.||...|:.||:..|.::   ..
Zfish   410 RGGARMLDAATCSTKEFLVALTDILENPTYRQNMQKLSNLHRDRPLHPLDKAVYWIEFVLRNKGA 474

  Fly   464 PRLFKHFAQTETLAQNFFVANSLDVLTVPLIVLLAAVVSLANLVYVLYTGGSKRQQ 519
            |.|     :.|....:.|....|||:.:.|.:||..:..    ||.:.....|||:
Zfish   475 PHL-----RAEAYNVSEFSYYCLDVVALVLFMLLGTLGG----VYTICKRRPKRQE 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	61/240 (25%)
ugt5g2	NP_001186305.1	egt	3..507	CDD:223071	136/556 (24%)
ugt5g2	NP_001186305.1	UDPGT	25..513	CDD:278624	132/545 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584666
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.940