Protein Alignment Ugt305A1 and UGT1A1

DIOPT Version :9

• Sequence 1: NP_001261394.1
• Gene: Ugt305A1 / 59217
• FlyBaseID: FBgn0042179
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_000454.1
• Gene: UGT1A1 / 54658
• HGNCID: 12530
• Length: 533
• Species: Homo sapiens
• Alignment Length: 583
• Identity: 136/583 - (23%)
• Similarity: 247/583 - (42%)
• Gaps: 111/583 - (19%)

  Fly     2 RALCLLPVFVLLGRFCSLEAANILCLVSTAKHNNPGWSKPL--FDALLANGHSLLVISTAPNPEP 64
            |.|.|..:..:||...| .|..||.:.....|    |...|  ...|...||.::|::    |:.
Human     9 RPLVLGLLLCVLGPVVS-HAGKILLIPVDGSH----WLSMLGAIQQLQQRGHEIVVLA----PDA 64

  Fly    65 KKQV-DGLVY----YHLPNEYDVMKRHFLLEEPREYISMVTLNQLLVWYE-------VLLGSCRA 117
            ...: ||..|    |.:|.:.:.:|..|:......:.:...|.:::..|:       :||..|..
Human    65 SLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDSAMLLSGCSH 129

  Fly   118 LLNSDTMSSKRPELTAQLS-MEYDLIITDVTQGIECLMDSVSGWRSKPVLGLSAGKLTPDLMSLL 181
            ||::       .||.|.|: ..:|:::||  ..:.|          .|::.......|...:..|
Human   130 LLHN-------KELMASLAESSFDVMLTD--PFLPC----------SPIVAQYLSLPTVFFLHAL 175

  Fly   182 RAENTINAARIPHYISQVPKT-------MGFWNRLHNHIMYYAEPLIHLVITRP---VLSELMKT 236
            .......|.:.|:..|.||:.       |.|..|:.|.::.:::..:..|:..|   :.||.::.
Human   176 PCSLEFEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQR 240

  Fly   237 E----NAFPKLQLVLLNTHPTLDYVQNLPPGVIEVGGLHIKNQTSPLPTYIQEFTEKFFDGIVYI 297
            |    :......:.|..:....||.:.:.|.::.|||::..:| :||.   |||.
Human   241 EVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQ-NPLS---QEFE---------- 291

  Fly   298 NMPYIEYMNDQGLK--AMYTMIHGNPNVAFIWNVEQLEQLP--------AKKPNLL---TLHVNQ 349
              .||....:.|:.  ::.:|:...|....:...:.|.::|        ..:|:.|   |:.|..
Human   292 --AYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKW 354

  Fly   350 SLQQDILAMQYVKGFLNHGDSFSLQEAIHYGVPVVVLPLKLEEFNNAQRVMERNLGVMLQVKEFN 414
            ..|.|:|.....:.|:.|..|..:.|:|..|||:|::||..::.:||:|:..:..||.|.|.|..
Human   355 LPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT 419

  Fly   415 QSSLSDALTRILDEERF------ISALHQAQLKFRTRPQSALELAVWHAEQLI---AEPRLFKHF 470
            ...|.:||..:::::.:      :|:||      :.||...|:|||:..|.::   ..|.| :..
Human   420 SEDLENALKAVINDKSYKENIMRLSSLH------KDRPVEPLDLAVFWVEFVMRHKGAPHL-RPA 477

  Fly   471 AQTETLAQNFFVANSLDVLTVPLIVLLAAVVSLANLVYVLYTGGSKRQQTLEKAVLKKRKKSK 533
            |...|    ::..:||||:.    .|||.|:::|.:.:.....| .|:...:|..:||..|||
Human   478 AHDLT----WYQYHSLDVIG----FLLAVVLTVAFITFKCCAYG-YRKCLGKKGRVKKAHKSK 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	59/237 (25%)
UGT1A1	NP_000454.1	UDPGT	28..524	CDD:278624	124/554 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150330
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840