Protein Alignment Ugt305A1 and UGT1A4

DIOPT Version :9

• Sequence 1: NP_001261394.1
• Gene: Ugt305A1 / 59217
• FlyBaseID: FBgn0042179
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_009051.1
• Gene: UGT1A4 / 54657
• HGNCID: 12536
• Length: 534
• Species: Homo sapiens
• Alignment Length: 546
• Identity: 129/546 - (23%)
• Similarity: 223/546 - (40%)
• Gaps: 122/546 - (22%)

  Fly    46 LLANGHSLLVISTAPNPEPKKQ-VDGLVYYHLP---NEYDVM----------KRHFLLEEPREYI 96
            |.|.||..:|::...|...|:: ...|..|.:|   .|:|.:          ..|.|....|
Human    51 LHARGHQAVVLTPEVNMHIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFETEHLLKRYSR--- 112

  Fly    97 SMVTLNQLLVWYEVLLGSCRALLNSDTMSSKRPELTAQLSMEYDLIITDVTQGIECLM------D 155
            ||..:|.:.:   .|...|..||:::.:..   .|.|   ..:|:::||.......::      .
Human   113 SMAIMNNVSL---ALHRCCVELLHNEALIR---HLNA---TSFDVVLTDPVNLCGAVLAKYLSIP 168

  Fly   156 SVSGWRSKPVLGLSAGKLTPDLMSLLRAENTINAARIPHYISQVPKT-------MGFWNRLHNHI 213
            :|..||..|.          ||        .....:.|:..|.:||.       |.|..|:.|
Human   169 AVFFWRYIPC----------DL--------DFKGTQCPNPSSYIPKLLTTNSDHMTFLQRVKN-- 213

  Fly   214 MYYAEPLIHLVIT-----RPVLSELMKTENAFPKL----QLVLLNTHPTLDYVQNLPPGVIEVGG 269
            |.|...|.::..|     ..:.|||.:.|.:...|    .:.|......:||.:.:.|.::.:||
Human   214 MLYPLALSYICHTFSAPYASLASELFQREVSVVDLVSYASVWLFRGDFVMDYPRPIMPNMVFIGG 278

  Fly   270 LHIKNQTSPLPTYIQEFTEKFFDGIVYINMPYIEYMNDQGLK--AMYTMIHGNPNVAFIWNVEQL 332
            ::..| ..||.   |||.            .||....:.|:.  ::.:|:...|....:...:.|
Human   279 INCAN-GKPLS---QEFE------------AYINASGEHGIVVFSLGSMVSEIPEKKAMAIADAL 327

  Fly   333 EQLP--------AKKPNLL---TLHVNQSLQQDILAMQYVKGFLNHGDSFSLQEAIHYGVPVVVL 386
            .::|        ..:|:.|   |:.|....|.|:|.....:.|:.|..|..:.|:|..|||:|::
Human   328 GKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMM 392

  Fly   387 PLKLEEFNNAQRVMERNLGVMLQVKEFNQSSLSDALTRILDEERF------ISALHQAQLKFRTR 445
            ||..::.:||:|:..:..||.|.|.|.....|.:||..:::::.:      :|:||      :.|
Human   393 PLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLH------KDR 451

  Fly   446 PQSALELAVWHAEQLI---AEPRLFKHFAQTETLAQNFFVANSLDVLTVPLIVLLAAVVSLANLV 507
            |...|:|||:..|.::   ..|.| :..|...|    ::..:||||:.    .|||.|:::|.:.
Human   452 PVEPLDLAVFWVEFVMRHKGAPHL-RPAAHDLT----WYQYHSLDVIG----FLLAVVLTVAFIT 507

  Fly   508 YVLYTGGSKRQQTLEKAVLKKRKKSK 533
            :.....| .|:...:|..:||..|||
Human   508 FKCCAYG-YRKCLGKKGRVKKAHKSK 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	59/241 (24%)
UGT1A4	NP_009051.1	UDPGT	29..525	CDD:278624	124/537 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150641
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840