Protein Alignment Ugt305A1 and UGT1A5

DIOPT Version :9

• Sequence 1: NP_001261394.1
• Gene: Ugt305A1 / 59217
• FlyBaseID: FBgn0042179
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_061951.1
• Gene: UGT1A5 / 54579
• HGNCID: 12537
• Length: 534
• Species: Homo sapiens
• Alignment Length: 588
• Identity: 130/588 - (22%)
• Similarity: 239/588 - (40%)
• Gaps: 156/588 - (26%)

  Fly    20 EAANILCLVSTAKHNNPGW---SKPLFDALLANGHSLLVISTAPNPEPKK--------------- 66
            |:..:|.:.:...|    |   .:.|.| |.|.||.::|::...|...|:
Human    27 ESGKVLVVPTDGSH----WLSMREALRD-LHARGHQVVVLTLEVNMYIKEENFFTLTTYAISWTQ 86

  Fly    67 -QVDGLVYYHLPNEYDVMKRHFLLEEPREYISMVTLNQLLVWYEVLLGSCRALLNSDTMSSKRPE 130
             :.|.|:..|..:.::.  .|.|::..|.   |..:|.:.:   ::..||..||:::.:
Human    87 DEFDRLLLGHTQSFFET--EHLLMKFSRR---MAIMNNMSL---IIHRSCVELLHNEAL------ 137

  Fly   131 LTAQLSMEYDLIITD-------------------VTQGIECLMDSVSGWRSKPVLGLSAGKLTPD 176
            :....:..:|:::||                   ..:.|.|.:|             ..|...|:
Human   138 IRHLHATSFDVVLTDPFHLCAAVLAKYLSIPAVFFLRNIPCDLD-------------FKGTQCPN 189

  Fly   177 LMSLLRAENTINAARIPHYISQVPKTMGFWNRLHNHIMYYAEPLIHL--VITRP---VLSELMKT 236
            ..|.           ||..::.....|.|..|:.|  |.|...|.:|  .::.|   :.|||.:.
Human   190 PSSY-----------IPRLLTTNSDHMTFLQRVKN--MLYPLALSYLCHAVSAPYASLASELFQR 241

  Fly   237 ENAFPKLQLVLLNTHPT---------LDYVQNLPPGVIEVGGLHIKNQTSPLPTYIQEFTEKFFD 292
            |     :.:|.|.:|.:         :||.:.:.|.::.:||::..| ..||.   |||.
Human   242 E-----VSVVDLVSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCAN-GKPLS---QEFE----- 292

  Fly   293 GIVYINMPYIEYMNDQGLK--AMYTMIHGNPNVAFIWNVEQLEQLP--------AKKPNLL---T 344
                   .||....:.|:.  ::.:|:...|....:...:.|.::|        ..:|:.|   |
Human   293 -------AYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNT 350

  Fly   345 LHVNQSLQQDILAMQYVKGFLNHGDSFSLQEAIHYGVPVVVLPLKLEEFNNAQRVMERNLGVMLQ 409
            :.|....|.|:|.....:.|:.|..|..:.|:|..|||:|::||..::.:||:|:..:..||.|.
Human   351 ILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLN 415

  Fly   410 VKEFNQSSLSDALTRILDEERF------ISALHQAQLKFRTRPQSALELAVWHAEQLI---AEPR 465
            |.|.....|.:||..:::::.:      :|:||      :.||...|:|||:..|.::   ..|.
Human   416 VLEMTSEDLENALKAVINDKSYKENIMRLSSLH------KDRPVEPLDLAVFWVEFVMRHKGAPH 474

  Fly   466 LFKHFAQTETLAQNFFVANSLDVLTVPLIVLLAAVVSLANLVYVLYTGGSKRQQTLEKAVLKKRK 530
            | :..|...|    ::..:||||:.    .|||.|:::|.:.:.....| .|:...:|..:||..
Human   475 L-RPAAHDLT----WYQYHSLDVIG----FLLAVVLTVAFITFKCCAYG-YRKCLGKKGRVKKAH 529

  Fly   531 KSK 533
            |||
Human   530 KSK 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	60/246 (24%)
UGT1A5	NP_061951.1	UDPGT	29..525	CDD:278624	124/577 (21%)
		egt	<262..508	CDD:223071	70/276 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150640
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840