DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt305A1 and UGT2B28

DIOPT Version :9

Sequence 1:	NP_001261394.1	Gene:	Ugt305A1 / 59217	FlyBaseID:	FBgn0042179	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_444267.1	Gene:	UGT2B28 / 54490	HGNCID:	13479	Length:	529	Species:	Homo sapiens

Alignment Length:	574	Identity:	119/574 - (20%)
Similarity:	223/574 - (38%)	Gaps:	133/574 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ALCLLPVFVLLGRFCSLEAANILC---LVSTAKHNNPGW--SKPLFDALLANGHSLLVISTA--- 59
            ||....|.:|:...|...:.:  |   ||.|.::::  |  .|.:...|:..||.:.|::::
Human     2 ALKWTSVLLLIHLGCYFSSGS--CGKVLVWTGEYSH--WMNMKTILKELVQRGHEVTVLASSASI 62

  Fly    60 ---------------PNPEPKKQVDGLVYYHLPNEYDVMKRHFLLEEPREYISMVTLNQLLVW-- 107
                           |....|.:.:.::...:....|:.|..|.|     |.|.   .|.::|
Human    63 LFDPNDAFTLKLEVYPTSLTKTEFENIIMQQVKRWSDIQKDSFWL-----YFSQ---EQEILWEF 119

  Fly   108 YEVLLGSCRALLNSDTMSSKRPELTAQLSMEYDLIITDVTQGIECLMDSVSGWRSKPVLGLSAGK 172
            :::....|:     |.:|:|:.....|.| .:|:|..|..                    ...|:
Human   120 HDIFRNFCK-----DVVSNKKVMKKLQES-RFDIIFADAF--------------------FPCGE 158

  Fly   173 LTPDLMSL-------LRAENTIN---------AARIPHYISQVPKTMGFWNRLHNHI-------- 213
            |...|:::       .....||.         .:.||..:|::...|.|..|:.|.|
Human   159 LLAALLNIPFVYSLCFTPGYTIERHSGGLIFPPSYIPVVMSKLSDQMTFMERVKNMIYVLYFDFW 223

  Fly   214 ----------MYYAEPLIHLVITRPVLSELMKTENAFPKLQLVLLNTHPTLDYVQNLPPGVIEVG 268
                      .:|:|     |:.||  :.|.:|   ..|..:.|:....:..:.....|.:..||
Human   224 FQMCDMKKWDQFYSE-----VLGRP--TTLFET---MGKADIWLMRNSWSFQFPHPFLPNIDFVG 278

  Fly   269 GLHIKNQTSPLPTYIQEFTEKFFD-GIVYINM-PYIEYMNDQGLKAMYTMIHGNPNVAFIWNVEQ 331
            |||.| ...|||..::||.:...: |:|..:: ..|..|..:....:.|.:...|. ..:|..:
Human   279 GLHCK-PAKPLPKEMEEFVQSSGENGVVVFSLGSVISNMTAERANVIATALAKIPQ-KVLWRFD- 340

  Fly   332 LEQLPAKKPNLLTLHVNQSL-----QQDILAMQYVKGFLNHGDSFSLQEAIHYGVPVVVLPLKLE 391
                 ..||:.|.|  |..|     |.|:|.:...:.|:.||.:..:.|||::|:|:|.:||..:
Human   341 -----GNKPDALGL--NTRLYKWIPQNDLLGLPKTRAFITHGGANGIYEAIYHGIPMVGIPLFWD 398

  Fly   392 EFNNAQRVMERNLGVMLQVKEFNQSSLSDALTRILDEERFISALHQAQLKFRTRPQSALELAVWH 456
            :.:|...:..:...|.|.....:.:.|.:||..::::..:...:.:..:....:|...|..||:.
Human   399 QPDNIAHMKAKGAAVRLDFHTMSSTDLLNALKTVINDPSYKENVMKLSIIQHDQPVKPLHRAVFW 463

  Fly   457 AEQLIAEPRLFKHFAQTETLAQNFFVANSLDVLTVPLIVLLAAVVSLANLVYVL 510
            .|.::.. :..||. :.......:|..:||||:.    .|||.|   |.:::|:
Human   464 IEFVMCH-KGAKHL-RVAARDLTWFQYHSLDVIG----FLLACV---ATVIFVV 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	52/225 (23%)
UGT2B28	NP_444267.1	UDPGT	24..525	CDD:278624	113/550 (21%)
UGT2B28	NP_444267.1	egt	<269..506	CDD:223071	62/255 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150546
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940