DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt305A1 and Ugt304A1

DIOPT Version :9

Sequence 1:	NP_001261394.1	Gene:	Ugt305A1 / 59217	FlyBaseID:	FBgn0042179	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster

Alignment Length:	541	Identity:	124/541 - (22%)
Similarity:	225/541 - (41%)	Gaps:	95/541 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLPVFVLLGR-FCSLEAANILCLVSTAKHNNPGWSKPLFDALLANGHSLLVISTAPNPEPKKQVD 69
            |||:|.|:.. .|.:.::.||.:.....|:......|...||...||.|.||.
  Fly     8 LLPMFWLISNSICWIRSSRILVIAPFESHSQCMLVTPYIQALKDRGHQLTVIH------------ 60

  Fly    70 GLVYYHLPNEYD------VMKRHFLLEEPREYISMVTLNQLLVWYEVLLGSCRALLNSDTMS-SK 127
              .|.|..::.:      :...:.:..|..|.:.:.:.|.  .|.|:  .|..:|:.:.|:: ..
  Fly    61 --AYKHCMHKIEDVTFIRIWYNNNVFLEFEESVGIASANN--KWEEI--SSMSSLMANATLNVLN 119

  Fly   128 RPELTAQLS--MEYDLII-----TDVTQGIEC--------LMDSVSGWRSKPVLGLSAGKLTPDL 177
            ..|:.|.:.  :.:|.::     :||..|:..        :...|:.|....::|.|...||..:
  Fly   120 NVEVRALMKSRITFDAVVLEAGYSDVLYGMAAHFSAQLIGICTCVADWNINNLVGFSTSTLTEPI 184

  Fly   178 MSLLRAENTINAARIPHYISQVPKTMGFWNRLHNHIMYYAEP--LIHLVI---TRPVLSELM-KT 236
            |. .||:          |:..|      |:|::|. :|..|.  ||:||.   .|.:..... ..
  Fly   185 MP-FRAK----------YVKNV------WDRIYNW-LYTTEEWLLINLVFLPKQRLIHDHFFGHL 231

  Fly   237 ENAFPKLQ----LVLLNTHPTLDYVQNLPPGVIEVGGLHIKNQTSPLPTYIQEFTEKFFDGIVYI 297
            |.:|.:::    |:|||.|.:|...:...||::||.||||..:...||:.:|.|.::...|::..
  Fly   232 EKSFHEIRQDFALMLLNQHFSLFRARPNVPGMVEVAGLHIPKEDPQLPSDLQVFIDEAEHGVILF 296

  Fly   298 NMPYIEYMNDQGLKAMYTMIHGNPNV--AFIWNVEQLEQLPAKKPNLLT--LHVNQSLQQDILAM 358
            ::...:...|...|....::....:|  ..||..:....:     :|.|  .|.....||.|||.
  Fly   297 SLGLEQDSKDLPRKTQEILVETFKSVPQRVIWKFDGESTM-----SLGTDIYHSKLLPQQAILAH 356

  Fly   359 QYVKGFLNHGDSFSLQEAIHYGVPVVVLPLKLEEFNNAQRVMERNLGVMLQVKEFNQSSLSDALT 423
            ..||.|::|....|:.||.:|..||:.||...::|.|.:.:.|..:.:.|.:.......|.||:.
  Fly   357 PNVKLFISHCGMMSVIEAAYYAKPVLGLPSFFDQFRNLEIMKEEGVALELNINSLTVKELKDAIH 421

  Fly   424 RILDEERFISALHQAQLKFRTRPQSALELAVWHAEQLI------------AEPRLFKHFAQTETL 476
            .:::|..:..:......:||.:|...|:.|::..|.:|            ::.:||.:::
  Fly   422 SMINEPEYRESALAISQRFRDQPIHPLDAAIYWTEYIIRYKGADHMKISQSQLKLFDYYS----- 481

  Fly   477 AQNFFVANSLDVLTVPLIVLL 497
            ..||.:..|...|.|.|:.|:
  Fly   482 LDNFIMVGSRLSLVVALVFLV 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	58/226 (26%)
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	117/512 (23%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	101/443 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445818
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	7.000