DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt305A1 and Ugt8

DIOPT Version :9

Sequence 1:	NP_001261394.1	Gene:	Ugt305A1 / 59217	FlyBaseID:	FBgn0042179	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_062149.1	Gene:	Ugt8 / 50555	RGDID:	3938	Length:	541	Species:	Rattus norvegicus

Alignment Length:	634	Identity:	126/634 - (19%)
Similarity:	225/634 - (35%)	Gaps:	160/634 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PVFVLLGRFCSL-EAANILCLVSTAKHNNPGWSKPLFDALLANG-HSLLVISTAPNPEPKKQVDG 70
            |.|:||.....: .||.|:.:......::....|.|..||...| |::.::|...:.:|.
  Rat     6 PYFMLLWSAVGIARAAKIIIVPPIMFESHLYIFKTLASALHERGHHTVFLLSEGRDIDPS----- 65

  Fly    71 LVYYHLPNEYDVMKRH-----------FLLEEPREYIS----MVTLNQLLVWYEVLLGSCRALLN 120
                   |.|. ::|:           ||..:.|...|    .|.|..:|..|         ..|
  Rat    66 -------NHYS-LQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAVELVDILDHY---------TKN 113

  Fly   121 SDTMSSKRPELTAQLSMEYDLIITDVTQGIECLMDSVSGWRSKPVLGLSAGKLTPDLMSLLRAEN 185
            .|.|...:..:......::||::.|        .:.:.|:....:||:.....:..|........
  Rat   114 CDMMVGNQALIQGLKKEKFDLLLVD--------PNDMCGFVIAHLLGVKYAVFSTGLWYPAEVGA 170

  Fly   186 TINAARIPHYISQVPKTMGFWNRLHNHIMYYAEPLIHLVITRPVLSELMKTENAFPK-------- 242
            ....|.:|.:.|.:...|.|..|:.|..:|....:....:..|....:|:..|..|.
  Rat   171 PAPLAYVPEFNSLLTDRMNFLERMKNTGVYLISRMGVSFLVLPKYERIMQKYNLLPAKSMYDLVH 235

  Fly   243 -LQLVLLNTHPTLDYVQNLPPGVIEVGGLHIKNQTSPLPTYIQEFTEKFFD-GIVYINM-PYIEY 304
             ..|.:|.|...|::.:...|.|:.|||: :....||||..:|.:.:...: |.|.::. ..::|
  Rat   236 GSSLWMLCTDVALEFPRPTLPNVVYVGGI-LTKPASPLPEDLQRWVDGAQEHGFVLVSFGAGVKY 299

  Fly   305 MNDQGLKAMYTMIHGNPNVAFIW------------NVEQLEQLPAKKPNLLTLHVNQSLQQDILA 357
            :::.....:...:...|. ..||            |.:.:|.||               |.|:|.
  Rat   300 LSEDIANKLAGALGRLPQ-KVIWRFSGTKPKNLGNNTKLIEWLP---------------QNDLLG 348

  Fly   358 MQYVKGFLNHGDSFSLQEAIHYGVPVVVLPLKLEEFNNAQRVMERNLGVMLQVKEFNQSSLSDAL 422
            ...::.||:||...|:.|.:::|||||.:||..:.::...||..:.:|::|:.....:..|.|||
  Rat   349 HSNIRAFLSHGGLNSIFETMYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWNTVTEGELYDAL 413

  Fly   423 TRILDEERF------ISALHQAQ-----------LKFRTRPQSALELAVWHAEQLIAEPRLFKHF 470
            .::::...:      :|.:|:.|           :.:..|...|     .|....:.:....::|
  Rat   414 VKVINNPSYRQRAQKLSEIHKDQPGHPVNRTTYWIDYILRHDGA-----HHLRSAVHQISFCQYF 473

  Fly   471 AQTETLAQNFFVANSLDVLTVPLIVLLAAVVSLANLVYV---LYTGGSKRQQTLEKAVLKKRKKS 532
                             :|.:..::||.||.....:.||   :|                 ||..
  Rat   474 -----------------LLDIAFVLLLGAVALYFIVSYVTKFIY-----------------RKVK 504

  Fly   533 KKSSPQTFTPVNVTLKLETSELLEDLNNEILEGEEELLKGEEKPLEEKK 581
            ...|..|.:.||           ....|.||.|.   .||......|||
  Rat   505 SLCSRSTHSTVN-----------GHYQNGILNGR---YKGNGHIKHEKK 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	54/258 (21%)
Ugt8	NP_062149.1	egt	8..490	CDD:223071	107/550 (19%)
Ugt8	NP_062149.1	UDPGT	21..502	CDD:278624	106/566 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344204
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48043
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.030