DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt305A1 and RGD1559459

DIOPT Version :9

Sequence 1:	NP_001261394.1	Gene:	Ugt305A1 / 59217	FlyBaseID:	FBgn0042179	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_003751392.1	Gene:	RGD1559459 / 501907	RGDID:	1559459	Length:	530	Species:	Rattus norvegicus

Alignment Length:	606	Identity:	138/606 - (22%)
Similarity:	220/606 - (36%)	Gaps:	160/606 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ALCLLPVFVLLGRFCSLEAANILCLVSTAKHNNPGW--SKPLFDALLANGHSLLVISTAPNPEPK 65
            ||.||.:.:..|   |.....:|.......|    |  .|.:...|:..||.::|:.  |:....
  Rat     8 ALLLLHLTIFFG---SGSGGKVLVWPVEFSH----WLNLKIILSELVKKGHEVVVLK--PSVSFS 63

  Fly    66 KQVD---GLVYYHLPNEYDVMKRHFLLEEPREYISMVTLNQLL-------VW-YEVLLGS----- 114
            .:||   .:.:...|:.|.:        ...|.|.|..:|:.:       .| |.::|..
  Rat    64 YEVDKTSAIEFESFPSSYSI--------ADVEVIFMDCVNESIYELPKQSFWGYFLMLQKLFERT 120

  Fly   115 -------CR-ALLNSDTMSSKRPELTAQLSMEYDLIITDVTQGIECLM----------------- 154
                   || |..|.:.|       |...:..:|:|:.|.......|:
  Rat   121 SDYSERLCRDAAFNKELM-------TKLQNSGFDVILADPFTPCGDLLAEILKIPLVYSLRFFPG 178

  Fly   155 ---DSVSGWRSKPVLGLSAGKLTPDLMSLLRAENTINAARIPHYISQVPKTMGF-------WNRL 209
               :..||....|      ....|..||.|....|. ..|:.|.|..:.....|       ||.|
  Rat   179 STYEKYSGGLPMP------PSYVPIAMSELSDRMTF-VERVKHMIYVLCFDFWFQVFDEKKWNEL 236

  Fly   210 HNHIMYYAEPLIHLVITRP-VLSELMKTENAFPKLQLVLLNTHPTLDYVQNLPPGVIEVGGLHIK 273
                  |.|     |:.|| .|||.|      .|..:.|:.|:..|::...:.|....|||||.:
  Rat   237 ------YTE-----VLGRPTTLSETM------AKADIWLIRTYWDLEFPHPVLPNFDFVGGLHCR 284

  Fly   274 NQTSPLPTYIQEFTEKFFD-GIVYINMPYIEYMNDQGLKAMYTMIHGNPNVAFIWNVEQ--LEQL 335
             ...|||..|::|.:...: |:|..::        ..:....|....|...|.:..:.|  |.:.
  Rat   285 -PAKPLPKEIEDFVQSSGEHGVVVFSL--------GSMVGSLTEERANVIAAGLAQIPQKVLWRF 340

  Fly   336 PAKKPNLLTLHVNQSL-----QQDILAMQYVKGFLNHGDSFSLQEAIHYGVPVVVLPLKLEEFNN 395
            ..|||.  ||..|..|     |.|:|.....:.|:.||.:..:.|||::|:|||.:||..::.:|
  Rat   341 EGKKPE--TLGSNTRLYKWIPQNDLLGHPKTRAFITHGGTNGIYEAIYHGIPVVGIPLFGDQKDN 403

  Fly   396 AQRVMERNLGVMLQVKEFNQSSLSDALTRILDEERF------ISALHQAQLKFRTRPQSALELAV 454
            ...:..:...|.|.....:.:.|..||..:.::..:      :|.:|..|      |...|:.||
  Rat   404 IVHLKTKGAAVRLDFLTMSSTDLLTALRTVTNDPSYKENAMRLSRIHHDQ------PVKPLDRAV 462

  Fly   455 WHAEQLIAEPRLFKHFAQTETLAQNFFVA---------NSLDVLTVPLIVLLAAVVSLANLVYVL 510
            :..|           |......|::..||         :||||:.    .|||.||:   ::::|
  Rat   463 FWIE-----------FVMRHKGAKHLRVAGHDLSWVQYHSLDVIG----FLLACVVT---VMFIL 509

  Fly   511 YTGGSKRQQTLEKAVLKKRKK 531
            ........|...||..||:|:
  Rat   510 KKCCLFCCQKFTKAGRKKKKE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	58/232 (25%)
RGD1559459	XP_003751392.1	UDPGT	24..527	CDD:278624	129/582 (22%)
RGD1559459	XP_003751392.1	egt	<270..508	CDD:223071	67/272 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344153
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48043
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.030