DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt305A1 and Ugt303B2

DIOPT Version :9

Sequence 1:	NP_001261394.1	Gene:	Ugt305A1 / 59217	FlyBaseID:	FBgn0042179	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster

Alignment Length:	569	Identity:	131/569 - (23%)
Similarity:	240/569 - (42%)	Gaps:	115/569 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LPVFVLLGRFCSLEAANILCLVSTAKHNNPGWSKPLFDALLANGHSLLVISTAPNPEPKKQVDGL 71
            |.:::.||     :|||||.:......:.....:||..||:..||.:.:::.|..|   .::||:
  Fly    16 LNLYLELG-----QAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTPADYP---AKIDGV 72

  Fly    72 VYYHLP--NE--YDVMKR----HFLLEEPREYISMVTLNQLLVWYEVLLGSCRALLNSDTMSSKR 128
            .:..:|  |:  .::||.    ..|.::.||.:.:.|     ::|.|    ..|:||::.:..
  Fly    73 RHIRVPMLNQLMQNLMKNDQFFDALGDKWREGVLVST-----IFYNV----SHAILNNNGVQM-- 126

  Fly   129 PELTAQLSMEYDLIITDVTQGIECLMDSVSG---WRSKPVLGLS-----------AGKLTPDLMS 179
              |....|:.:|:|:.:.:.     :|::.|   :.:..:||:|           ||.|.|.:..
  Fly   127 --LMRDKSIRFDMIMVEASH-----LDALYGLAEFYNATLLGISCMHMTWHIDYLAGNLAPSVYE 184

  Fly   180 LL-----RAENTINAARIPHYISQVPKTMGFWNRLHNHIMYYAEPLIHLVITRPVLSELMKTENA 239
            .:     ..:||                  |.:|..|.|....|.|:..::.||....|.|....
  Fly   185 PISPNGFALDNT------------------FLSRWSNWIYITEEKLLERLVFRPAQVRLFKKFFG 231

  Fly   240 FP---------KLQLVLLNTHPTLDYVQNLPPGVIEVGGLHIKNQTSPLPTYIQEFTEKFFDGIV 295
            :|         :..::|:|:|.::..|:...|.:|||.|:|:.....|....:|::.::...|.:
  Fly   232 YPAEKLDELRARFSVILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLDEAEHGAI 296

  Fly   296 YINMP---YIEYMNDQGLKAMYTMIHGNPNVAFIWNVEQLEQLPAKKPNLLTLHVNQSLQQDILA 357
            |.:|.   .|:|: .:.::....::........||..| |..|..|..|:..:  ::..|:.:||
  Fly   297 YFSMGQDILIKYL-PENMQKQLLLVFLQMKQRVIWKSE-LSMLANKSENIYVM--DKVPQRMVLA 357

  Fly   358 MQYVKGFLNHGDSFSLQEAIHYGVPVVVLPLKLEEFNNAQRVMERNLGVMLQVKEFNQSSLSDAL 422
            ...::.|:.||...|:.|||..|||::.|||..::|||..||....:..:|...:.|..:|.:.:
  Fly   358 HPNLRLFITHGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTLIETI 422

  Fly   423 TRILDEERFISALHQAQLKFRTRPQSALELAVWHAEQLIAEPRLFKHFAQTETLAQNFFVANSLD 487
            ..:|:...:.....:....||.||.|.|:.|:|..|..:.. |...|.              .|:
  Fly   423 KELLENPSYAQRAKEMAASFRDRPMSPLDTAIWWTEYALRN-RDTSHM--------------RLN 472

  Fly   488 VLTVPLI------------VLLAAVV-SLANLVYVLYTGGSKRQQTLEK 523
            |..:||:            |.|..|. ||..|.:.||.....|...|::
  Fly   473 VEEIPLMRYYRLDSILTFGVRLGCVCGSLIFLGWRLYQKNRNRHTRLQE 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	58/221 (26%)
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	112/483 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445814
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	7.000