DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt305A1 and Ugt37A3

DIOPT Version :9

Sequence 1:	NP_001261394.1	Gene:	Ugt305A1 / 59217	FlyBaseID:	FBgn0042179	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	586	Identity:	125/586 - (21%)
Similarity:	231/586 - (39%)	Gaps:	148/586 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLGRFCSLEAANILCLVSTAKHNNPGWSKPLFDALLANGHSLLVISTAPNPEPKKQVDGLVYYHL 76
            :||.|.||..::::..:|.||            .|..|||::.|::..   :|......:....:
  Fly    27 ILGLFPSLSPSHLIIQMSAAK------------VLAENGHNVTVVTVL---KPVVNHKNITVIQV 76

  Fly    77 PNEYDVMKRHFLLEEPREYIS--------------MVTLNQLLVWYEVLLGSCRALLNSDTMSSK 127
            |          |.:|..:.:|              .::|.::....:.::..     |::|:.:.
  Fly    77 P----------LSKEEAQQMSDTIGAMSKNDNSNMALSLLRMSDQMDFMIRK-----NAETLMND 126

  Fly   128 R-PELTAQLSMEYDLIITDVTQGIECLMDSVSGWRSK---PVLGLS------------------- 169
            | .:|......::||:|:..     .:.|...|:..|   ||:.|:
  Fly   127 RVRDLYLNRGNKFDLVISGY-----FMNDFQLGFARKVNAPVIVLATMPPNHLLNPLIGNPLEVS 186

  Fly   170 -AGKLTPDLMSLLRAENTINAARIPHYISQVPKTMGFW---------NRLHNHIMYYAEPLIHLV 224
             ||...|       ||.: .|......:|...:::||.         ||.....:|..:|.:
  Fly   187 YAGISNP-------AEGS-KAVTFQRRLSSYMQSLGFGVFSHLSERRNRNWYKEVYGNDPKM--- 240

  Fly   225 ITRPVLSELMKTENAFPKLQLVLLNTHPTLD-YVQNLPPGVIEVGGLHIKNQTSPLPTYIQEFTE 288
               |..||::|..:      ||..::|...: .::...|..||:||:.||::..|||..|.||..
  Fly   241 ---PEYSEMLKNTS------LVFFSSHAASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAEFLG 296

  Fly   289 KFFDGIVYINMPYIEYMNDQGLKAMYTMIHGNPNVA-------------FIWNVEQLEQLPAKKP 340
            ...||.:.:::.    .|.||.       |.||:..             .||..|..|..|.|..
  Fly   297 NATDGAILLSLG----SNVQGK-------HLNPDTVAKMFNVLSKLKERVIWKWEDQENTPGKSA 350

  Fly   341 NLLTLHVNQSLQQDILAMQYVKGFLNHGDSFSLQEAIHYGVPVVVLPLKLEEFNNAQRVMERNLG 405
            |:  |:.....|.||||...:|.|:||.....:.|:.::|.|::.||:..::..||..:::...|
  Fly   351 NI--LYSKWLPQDDILAHPNIKLFINHAGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFG 413

  Fly   406 VMLQVKEFNQSSLSDALTRILDEERFISALHQAQLKFRTRPQSALELAVWHAEQLIAEPRLFKHF 470
            :.|.:....:....:|:..||...::...:......:|.||.:|.|..::..|.:|..     |.
  Fly   414 LTLSLLTLEEKPFQEAILEILSNPQYAERVKSFSTLYRDRPMTARESFLYWTEYVIRH-----HG 473

  Fly   471 A---QTETLAQNFFVANSLDVLTVPLIVLLAAVVSLANLVYVLYTGGSKRQQTLEKAVLKKRKKS 532
            |   |:..:..:|..||::|:..:..::|::.:|.:..||..:|           :..:.|.||.
  Fly   474 AAHLQSPLVHMSFIAANNIDICFLIFVILVSVLVLIKFLVQFIY-----------RRFISKPKKE 527

  Fly   533 K 533
            |
  Fly   528 K 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	59/232 (25%)
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	113/535 (21%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	117/572 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445828
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.950