DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt305A1 and Ugt35A1

DIOPT Version :9

Sequence 1:	NP_001261394.1	Gene:	Ugt305A1 / 59217	FlyBaseID:	FBgn0042179	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	125/543 - (23%)
Similarity:	230/543 - (42%)	Gaps:	99/543 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 PGWSKPLF-----DALLANGHSLLVIST--APNPEPKKQVDGLVYYHLPNEYDVM---------- 83
            ||.|:.:|     ..|...||::.||:|  :...||..:|.|....|     ::|
  Fly    41 PGRSQYIFAEQFMKELAHRGHNVTVINTFGSDKNEPNFRVIGAKKIH-----EIMAAFGNADYTQ 100

  Fly    84 --KRHFLLEEPREYISMVTLNQLLVWYEVLL--GSCRALLNSDTMSSKRPELTAQLSMEYDLIIT 144
              .:..:|....::::::|.:        :|  .:.:.||||              ..::||:|.
  Fly   101 TASQWQMLTMTTQFLNLLTTS--------ILDDAAVKDLLNS--------------GEKFDLVIM 143

  Fly   145 DVTQGIECLMDSVSGWRSKPVLGLSA-----------GKLTPDLMSLLRAENTINAARIPHYISQ 198
            :..| .|.|...:..:.:: .:|:|:           |.::|             .:..|..:|.
  Fly   144 EAVQ-TEALFGLIQHFGAE-TIGISSYGTDTHIDELMGNISP-------------LSYNPLLLSS 193

  Fly   199 VPKTMGFWNRLHN----HIMYYAEPLIHLVITRPVLSELMKT-----ENAFPKLQLVLLNTHPTL 254
            ..:.|.|.:|:.|    .:|:..:.::||...|.:.::...|     :.......|:||..|.:|
  Fly   194 RTEQMDFKDRVMNVFEASVMWLHKRIVHLPSQRDLYAKYFPTARKSLDEVLDSFALMLLGQHFSL 258

  Fly   255 DYVQNLPPGVIEVGGLHI--KNQTSPLPTYIQEFTEKFFDGIVYINMPYIEYMND--QGLKAMYT 315
            .|.:...|.:|||||||:  |.:..||...:.||.|:...|::|.:|.......|  ...:.|..
  Fly   259 SYPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQSEKGVIYFSMGSNIKSKDLPPSTRKMLM 323

  Fly   316 MIHGNPNVAFIWNVEQLEQLPAKKPNLLTLHVNQSL-QQDILAMQYVKGFLNHGDSFSLQEAIHY 379
            ....:.....:|..|. :|||.|..|:.   :::.. |.||||...||.|:.||...|..|:|::
  Fly   324 QTFASVPQRVLWKFED-DQLPEKPDNVF---ISKWFPQPDILAHPNVKLFITHGGLLSTIESIYF 384

  Fly   380 GVPVVVLPLKLEEFNNAQRVMERNLGVMLQVKEFNQSSLSDALTRILDEERFISALHQAQLKFRT 444
            |.|::.||:..::..|.||..:...|:...:...|.:.|:..:..:|....:.:|.......||.
  Fly   385 GKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSYAAAAQTKSKLFRD 449

  Fly   445 RPQSALELAVWHAEQLIAEPRLFKHFAQTETLAQNFFVANSLD----VLTVPLIVLLAAVVSLAN 505
            :.::|||.|:|..|.::.. :..||. :..:...:|...:.||    ::.:..:.||..|:.:..
  Fly   450 QKETALERAIWWTEYVLRH-KGAKHL-RCASRDLDFIQFHGLDTWGLLIAITFVSLLIVVILIKC 512

  Fly   506 LVYVLYTGGSK-RQQTLEKAVLK 527
            |..|..:..|| |:...|.:.||
  Fly   513 LQRVFVSLISKIRKNRAEASKLK 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	65/223 (29%)
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	110/479 (23%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	117/518 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445809
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	7.000