DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt305A1 and F10D2.8

DIOPT Version :9

Sequence 1:	NP_001261394.1	Gene:	Ugt305A1 / 59217	FlyBaseID:	FBgn0042179	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001309630.1	Gene:	F10D2.8 / 266913	WormBaseID:	WBGene00017334	Length:	494	Species:	Caenorhabditis elegans

Alignment Length:	530	Identity:	113/530 - (21%)
Similarity:	199/530 - (37%)	Gaps:	82/530 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VLLGRFCSLEAANILCLVSTAKHNNPGWSKPLFDALLANGHSL-----LVISTAPNPEPKKQVDG 70
            |:|....|..:.|.|.......|::..:...:.|||...||::     .::....|....|....
Worm     6 VILSLIYSTYSYNFLVFCPLFGHSHTKFFATIADALTDAGHNVTFFTPTIVEKYRNVSYTKLTKD 70

  Fly    71 LVYYHLPN---EYDVMKR-----HFLLEEPREY-ISMVTLNQLLVWYEVLLGSCRALLNSDTMSS 126
            :|:...|.   ||.....     .|..|:...| :....|.:..:....|..|....||..|
Worm    71 VVHMDAPKKLMEYGEQMESADFSRFWTEDSSFYNVGAADLYRCSIRLNGLFKSLMDYLNIKT--- 132

  Fly   127 KRPELTAQLSMEYDLIITDVTQGIECLMDSVSGWRSKPVLGLSAGKLTPDLMSLLRAENTINAAR 191
                ....||:.:|:.::....  |.:|.||......|.         .|.:|||  |...||..
Worm   133 ----FIPSLSLTHDVYLSKAIG--EPVMPSVVSDVCSPF---------GDKLSLL--ERAFNAFA 180

  Fly   192 IPHYISQVPKTMGFWNRLHNHIMYYAEPLIHLVITRPVLSELMKTENAFPKLQLVLLNTHPTLDY 256
            :| ||..|   :|:             | :|..::.|.....::|..  |:...:.||::|.||:
Worm   181 VP-YIDIV---LGY-------------P-VHNTLSAPYTEIDIRTIE--PEASFLFLNSNPFLDF 225

  Fly   257 VQNLPPGVIEVGGLHIK-NQTSPLPTYIQEFTEKFFDGI------VYINMPYIEYMNDQGL---K 311
            .:......:|:||:.:. ||...     |:...|:.|.:      :.::...:.:..|..|   |
Worm   226 PRPTLTKTVEIGGITVDLNQLKS-----QQLDSKWSDILNLREKTMLVSFGSVFFSKDMPLENKK 285

  Fly   312 AMYTMIHGNPNVAFIWNVE--QLEQLPAKKPNLLTLH-VNQSLQQDILAMQYVKGFLNHGDSFSL 373
            .:...:....||.|||..|  .:|....   .:..:| |....|..:||.:.:..|..|....|:
Worm   286 VIANSMTEFKNVTFIWKYEGNDIEDFAR---GIQNIHFVKWVPQTALLANRRLSAFFTHAGLGSI 347

  Fly   374 QEAIHYGVPVVVLPLKLEEFNNAQRVMERNLGVMLQVKEF-NQSSLSDALTRILDEERFISALHQ 437
            .|..:.|.|.::.||..::..||:.::..|..:.|...:. |...:.:|...||.:..:.....:
Worm   348 NEVSYLGKPSILCPLFADQMRNAKMLVRHNGSIELSKYDLGNSKKIIEAFQAILFDSSYAENAQK 412

  Fly   438 AQLKFRTRPQSALELAVWHAEQLIAEPRL--FKHFAQTETLAQNFFVANSLDVLTVPLIVLLAAV 500
            ...:...:|....::.|.|||......||  ...:::..:..:.|.    |||.|:.::||...|
Worm   413 LAEQLENQPIKPEKMMVKHAEFAARFGRLPSLDPYSRKMSFVEYFL----LDVATICVLVLACVV 473

  Fly   501 VSLANLVYVL 510
            ..|..:|..|
Worm   474 FVLTRVVQFL 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	49/232 (21%)
F10D2.8	NP_001309630.1	UDPGT	29..492	CDD:278624	107/507 (21%)
F10D2.8	NP_001309630.1	Glycosyltransferase_GTB_type	<215..461	CDD:299143	53/257 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48043
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100