DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt305A1 and Ugt2b5

DIOPT Version :9

Sequence 1:	NP_001261394.1	Gene:	Ugt305A1 / 59217	FlyBaseID:	FBgn0042179	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_033493.3	Gene:	Ugt2b5 / 22238	MGIID:	98900	Length:	530	Species:	Mus musculus

Alignment Length:	609	Identity:	136/609 - (22%)
Similarity:	240/609 - (39%)	Gaps:	166/609 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ALCLLPVFVLLGRFCSLEAANILCLVSTAKHNNPGWS--KPLFDALLANGHSLLVISTAPNP--- 62
            ||.||.:...   |.|::...:|.......|    |.  |.:.|.|:..||.:.|:  .|:.
Mouse     8 ALLLLQISCC---FRSVKCGKVLVWPMEFSH----WMNIKIILDELVQRGHEVTVL--RPSAYYV 63

  Fly    63 -EPKKQVDGLVYYHLPNEY--DVMKRHFL-------LEEPRE---YISMVTLNQLLVWYEVLLGS 114
             :|||. .||.:...|...  |.::..|:       .|.||:   ..|.:..|.:..:.:..|..
Mouse    64 LDPKKS-PGLKFETFPTSVSKDNLENFFIKFVDVWTYEMPRDTCLSYSPLLQNMIDEFSDYFLSL 127

  Fly   115 CRALLNSDTMSSKRPELTAQL-SMEYDLIITDVTQGIECLMDSVSGWRSKPVLGLSAGKLTPDLM 178
            |:     |.:|:|  ||..:| ..::|::::|                  ||  .|.|:|..:|:
Mouse   128 CK-----DVVSNK--ELMTKLQESKFDVLLSD------------------PV--ASCGELIAELL 165

  Fly   179 SL-----------LRAENT-----INAARIPHYISQVPKTMGFWNRLHNHI-------------- 213
            .:           .:.|.:     :..:.:|..:|.:...|.|..|:.|.|
Mouse   166 QIPFLYSIRFSPGYQIEKSSGRFLLPPSYVPVILSGLGGQMTFIERIKNMICMLYFDFWFQMFND 230

  Fly   214 ----MYYAEPLIHLVITRPVLSELMKTENAFPKLQLVLLN-----THPTLDYVQNLPPGVIEVGG 269
                .:|:|     .:.||  :.|::|... .::.|:..|     .||||       |.|..|||
Mouse   231 KKWDSFYSE-----YLGRP--TTLVETMGQ-AEMWLIRSNWDLEFPHPTL-------PNVDYVGG 280

  Fly   270 LHIKNQTSPLPTYIQEFTEKFFD-GIVYINM-PYIEYMNDQGLKAMYTMIHGNPNVAFIWNVEQL 332
            ||.| ...|||..::||.:...| |:|..:: ..:..|.::...|:            .|.:.|:
Mouse   281 LHCK-PAKPLPKDMEEFVQSSGDHGVVVFSLGSMVSNMTEEKANAI------------AWALAQI 332

  Fly   333 EQ-----LPAKKPNLLTLHVNQSL-----QQDILAMQYVKGFLNHGDSFSLQEAIHYGVPVVVLP 387
            .|     ...|.|  .||..|..:     |.|:|.....|.|:.||.:..:.|||::|:|::.:|
Mouse   333 PQKVLWKFDGKTP--ATLGHNTRVYKWLPQNDLLGHPKTKAFVTHGGANGVYEAIYHGIPMIGIP 395

  Fly   388 LKLEEFNNAQRVMERNLGVMLQVKEFNQSSLSDALTRILD------EERFISALHQAQLKFRTRP 446
            |..|:.:|...::.:...|.|.::..::|.:.:||..:::      ...::|.:|..|      |
Mouse   396 LFGEQHDNIAHMVAKGAAVALNIRTMSKSDVLNALEEVIENPFYKKNAMWLSTIHHDQ------P 454

  Fly   447 QSALELAVWHAEQLIAEPRLFKHFAQTETLAQN--FFVANSLDVLTVPLIVLLAAVVSLANLVYV 509
            ...|:.||:..|.::...|. ||.   ..|..|  ::..:||||:...|..:...:|.....:..
Mouse   455 MKPLDRAVFWIEFVMRHKRA-KHL---RPLGHNLTWYQYHSLDVIGFLLSCVATTIVLSVKCLLF 515

  Fly   510 LYTGGSKRQQTLEKAVLKKRKKSK 533
            :|           :..:||..|.|
Mouse   516 IY-----------RFFVKKENKMK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	61/241 (25%)
Ugt2b5	NP_033493.3	egt	8..489	CDD:223071	125/557 (22%)
Ugt2b5	NP_033493.3	UDPGT	24..527	CDD:278624	128/587 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840564
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48043
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.030