DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt305A1 and ugt-59

DIOPT Version :9

Sequence 1:	NP_001261394.1	Gene:	Ugt305A1 / 59217	FlyBaseID:	FBgn0042179	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_501911.1	Gene:	ugt-59 / 187799	WormBaseID:	WBGene00011238	Length:	506	Species:	Caenorhabditis elegans

Alignment Length:	519	Identity:	103/519 - (19%)
Similarity:	194/519 - (37%)	Gaps:	54/519 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLPVFVLLGRFCSLEAANILCLVSTAKHNNPGWSKPLFDALLANGHSLLVISTAPNPEPKKQVDG 70
            :|.|..::..|.:|   |||..|.|..|::..::..|...|..:||.:.|:..        |||.
Worm     8 ILLVCTIINEFYTL---NILFYVPTLSHSHISFNTKLAQLLATSGHQVTVLLA--------QVDD 61

  Fly    71 LVYYHLPNEYDVMK----------RHFLLEEPREYISMVTLNQLLVWYEVLLGSCRALLNSDTMS 125
            .:......::.|::          |..|...|..|.....||. .::|::|..|...:.....|:
Worm    62 ALLIENATDFAVLRKKVGVPRGHLRQVLWSNPGPYEDSSPLNP-RIFYKLLKVSGTFVTACQNMA 125

  Fly   126 SKRPELTAQLSMEYDLIITDVTQGIECLMDSVSGWRSKPVLGLSAGKLTPDLMSLLRAENTINAA 190
            .....|::....::|:.:  |.|...|..........:..:.|||       .::.|.:......
Worm   126 FDHLFLSSLQQQKFDVGL--VEQYDSCGFGIFKSIGIENTVWLSA-------TAIYRPQAEALGV 181

  Fly   191 RIPHYISQVPK-------TMGFWNRLHNHIMYYAEPLIHLVITRPVLSELMKTENAF----PKLQ 244
            .:|:  |.||:       .|.|:.::.|.::..|...:..|..:...|.:...|...    .:..
Worm   182 HLPY--SYVPELFAHFSDKMSFFQKVINILIGQATSFVLDVFVQGFQSRIFGFEQGLGAISQETS 244

  Fly   245 LVLLNTHPTLDYVQNLPPGVIEVGGLHIKNQTSPLPTYIQEFTEKFFDGIVYINMPYIEY---MN 306
            .||:|:.|..||...:......:||:.:..:...|..|.|...:...:|.|.::...|..   |.
Worm   245 SVLINSVPFFDYSMPVSHQFSNIGGITVDKRDKKLDPYWQSIADSAENGFVLVSFGGIARTVDMT 309

  Fly   307 DQGLKAMYTMIHGNPNVAFIWNVEQLEQLPAKKPN--LLTLHVNQSLQQDILAMQYVKGFLNHGD 369
            :...:..|.......::.||...|.........|:  :||..:.   |..::|.:..|..:.||.
Worm   310 ESMQRIFYDSFARFSHITFIVKYETSSNSTISVPDNVILTPWIP---QLPLMAHKNYKTIITHGG 371

  Fly   370 SFSLQEAIHYGVPVVVLPLKLEEFNNAQRVMERNLGVMLQVKEFNQSSLSDALTRILDEERFISA 434
            ..|:.|...:..|::::||..:...|::....:.:.|:|.....::..:..|:..||...::...
Worm   372 WSSILETTMHSKPMILMPLFADHAKNSKVAESKGVAVLLDKMRLSRRRVVHAIYTILTNPKYTQN 436

  Fly   435 LHQAQLKFRTRPQSALELAVWHAEQLIAEPRLFKHFAQTETLAQNFFVANSLDVLTVPLIVLLA 498
            ..:....|...|....||..|...|.....|  |.||:.....:..|....|..|.:|.::|.|
Worm   437 CEKFSRMFSDTPIPHEELIEWRIRQAAKPSR--KAFAKHLRPKEPDFSYLKLGFLIIPAMILYA 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	44/223 (20%)
ugt-59	NP_501911.1	UDPGT	33..490	CDD:278624	89/481 (19%)
ugt-59	NP_501911.1	Glycosyltransferase_GTB_type	<247..492	CDD:299143	50/249 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.960