DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt305A1 and ugt-19

DIOPT Version :9

Sequence 1:	NP_001261394.1	Gene:	Ugt305A1 / 59217	FlyBaseID:	FBgn0042179	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_500912.2	Gene:	ugt-19 / 187129	WormBaseID:	WBGene00019515	Length:	532	Species:	Caenorhabditis elegans

Alignment Length:	590	Identity:	117/590 - (19%)
Similarity:	221/590 - (37%)	Gaps:	129/590 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VFVLLGRFCSLEAANILCLVSTAKHNNPGWSKPLFDALLANGHSLLVISTAPNPEPK---KQVDG 70
            :.:.....|...:..||...:...|::..:.....|.|...||::.|:....:...|   |....
Worm     7 ILIFAATICFASSYKILFYTNLFGHSHVKFLGAAADILTDAGHNVTVVMPVFDDSIKTSLKSTKN 71

  Fly    71 LVYYHLPNEY--------DVMKRHFLLEEPREYISMVTLNQLLVWYEVLLGSCRALL-NSDTMSS 126
            :::.:..::.        .::...:.::....:..:..:..:   .......|:.:| |::.:.:
Worm    72 IIFVNSSDDVAAFAKARTKMLNNLWTMDNTNPFTMLTRVGMM---SNTFSSQCKKVLTNTELIET 133

  Fly   127 KRPELTAQLSMEYDLIITD----------------VTQGI--ECLMDSVSGWRSKPVLGLSAGKL 173
            .:.|       .|||.:|:                ...||  ...:|.||....:|    :|...
Worm   134 MKAE-------NYDLAVTEPFDLCAYPFFEAINIRAHVGILSSSRLDHVSDVIGQP----AAPSY 187

  Fly   174 TPDLMSLLRAENTINAARIPHYISQVPKTMGFWNRLHNHIMYYAEPLIHLVI-TRPVLSELMKTE 237
            .|.|||       .|:.|           |..|.|..|.|.|.........| .|.  :|::|..
Worm   188 NPGLMS-------TNSDR-----------MTMWQRFVNVIQYACGSYFFSYIGDRE--AEVVKEI 232

  Fly   238 N--------AFPKLQLVLLNTHPTLDYVQNLPPGVIEVGGLHIKNQTSPLPTYIQEFTEKFFD-- 292
            |        ..|:...::.|..|.||:.......:|.:|||.:|.....|.  ::|...|..|
Worm   233 NPKWRSWREVVPEASFIMTNQIPLLDFPAPTFDKIIPIGGLSVKTDKKSLK--LEEKWSKILDIR 295

  Fly   293 ----------GIVYINMPYIEYMND--QGLKAMYTMIHGNPNVAFIWNVEQLEQLPAKKPNLLTL 345
                      ....::|| :||.|.  |.:|:|       |:..|||..|.|.....:  .:..:
Worm   296 KKNVFISFGSNARSVDMP-LEYKNTFLQVIKSM-------PDTTFIWKYEDLNDKFTE--GIENV 350

  Fly   346 HVNQSL-QQDILAMQYVKGFLNHGDSFSLQEAIHYGVPVVVLPLKLEEFNNAQRVMERNLGVMLQ 409
            ::...| |.::||.:.:..|:.||...|:.|....|.|.|::||..::..|.| :::|:.||.:
Worm   351 YLGDWLPQNELLADKRLNVFVTHGGLGSVTELSMMGTPAVMIPLFADQSRNGQ-MLKRHGGVAV- 413

  Fly   410 VKEFNQSSLSDA------LTRILDEERFISALHQAQLKFRTRPQSALELAVWHAEQLIAEPRL-- 466
               ..::.||||      :..:|:...:..:..:.....|.:|.:..|..:.:.|......:|
Worm   414 ---LKKTDLSDAKLVQSTIEEVLNNPEYRKSAERVAEMLRNQPTNPKETFLKYVEFTARFGKLPS 475

  Fly   467 FKHFAQTETLAQNFFVANSLDVLTVPLIVLLAAVVSLANLVYVLYTGGSKRQQTLEKAV--LKKR 529
            ..::.:..|..|.||    ||::         :::||..:|: ||......:.|::|..  ....
Worm   476 MDNYGRQLTFVQYFF----LDII---------SIISLITVVF-LYISYKVIRCTIKKCFGSRSSE 526

  Fly   530 KKSKK 534
            :||||
Worm   527 EKSKK 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	55/239 (23%)
ugt-19	NP_500912.2	egt	1..472	CDD:223071	99/515 (19%)
ugt-19	NP_500912.2	UDPGT	32..521	CDD:278624	109/553 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010