DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt305A1 and ugt-13

DIOPT Version :9

Sequence 1:	NP_001261394.1	Gene:	Ugt305A1 / 59217	FlyBaseID:	FBgn0042179	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_504317.2	Gene:	ugt-13 / 186766	WormBaseID:	WBGene00019232	Length:	532	Species:	Caenorhabditis elegans

Alignment Length:	587	Identity:	129/587 - (21%)
Similarity:	230/587 - (39%)	Gaps:	142/587 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CLLPVFVLLGRFCSLEAANILCLVSTAKHNNP--GWSKPLFDALLA-----NGHSLLVIS----T 58
            |||..||        .:.|||..       :|  |:|...|.:|:|     :||::.:..    .
Worm     9 CLLISFV--------SSKNILIY-------DPIFGFSHVKFVSLMAEIIANHGHNVTLFRPYHIA 58

  Fly    59 APNPEPKKQVDGLV---------YYHLPNEYDVMKRHFLLEEPREYISMVTLNQLLVWYEVLLGS 114
            .||      |||||         |:  |..||    ..|..|.:.:...        |.:.|:..
Worm    59 LPN------VDGLVKNKNIQIIDYF--PKHYD----ELLHAEKQTFPGF--------WNDPLISQ 103

  Fly   115 --CRALLNSDTMSSKRPELTAQL-----------SMEYDLIITDVTQGIECLMDSVSGWRSKPVL 166
              .|:|:.|..:|.:......||           |.::|::|::..:        ::|.....::
Worm   104 PVLRSLVVSKLISGEMKRTATQLLQDERVLNELRSKKFDVVISETFE--------ITGLYLAHII 160

  Fly   167 GLSAGKLTP-----DLMSLLRAENTINAARIPHYISQVPKTMGFWNRLHNHIMY----------- 215
            .:....:.|     ||..||...:.|..|:.|.  |::....||.:||::...|
Worm   161 DVPCIPMMPAVRYLDLGYLLGQPSLIGYAQQPG--SKMAPEAGFLDRLNDVYQYFFMSCETDWTS 223

  Fly   216 -YAEPLIHLVITRPV--LSELMKTENAFPKLQLVLLNTHPTLDYVQNLPPGVIEVGGLHI----- 272
             |....|...|.||:  ..:|::..      .:.:||::|.||:.......:::|||:.:
Worm   224 QYQNDNIEAAIGRPLPNWKDLLRNS------PIYILNSNPYLDFAVPTTATIVQVGGMTVDLKKM 282

  Fly   273 KNQTSPLPTYIQEFTEKFFDGIVYINMPYIEY-MNDQGLKAMYTMIHGNPNVAFIW-----NVEQ 331
            ||.......|.....|:.:..::........: |.|.....:..:.....:|.|||     :||.
Worm   283 KNVAKLSEEYETILAERDYAVLISFGSVIRSFQMPDNFKVGLIKLFESLSDVTFIWKYEKGDVEF 347

  Fly   332 LEQLPAKKPNLLTLHVNQSL-QQDILAMQYVKGFLNHGDSFSLQEAIHYGVPVVVLPLKLEEFNN 395
            .::||.      .:|:.:.: |..:||.:.||.|:.||...|..|..:.|.|.:::|:..::.||
Worm   348 QKRLPK------NVHLKKWVPQPSLLADKRVKLFVTHGGLGSTTEVAYTGKPALMVPIFGDQPNN 406

  Fly   396 AQRVMERNLGVMLQVKEF---NQSSLSDALTRILDEERFISALHQAQLKF---RTRPQSALELAV 454
            |. ::.|:.|.:...| |   |...|::.:..::...::   ..:|:|.|   ..:|....|..:
Worm   407 AD-MLARHGGAIAYSK-FDLANGEKLANTVKDMVFNPKY---KEKAELLFDVLSNQPIDPKENFI 466

  Fly   455 WHAEQLIAEPRLFKHFAQTETLAQNFFVAN-SLDVLT----VPLIVLLAAVVSLANLVYVLYTGG 514
            .|.|..:..|   .|.:|...:.|...:|. .|||:.    :.||....:.|:|..|..|:  .|
Worm   467 KHLEFAMKFP---NHRSQVPAVNQAGLIAQYYLDVIVFFVMISLISSYLSFVALCRLARVI--SG 526

  Fly   515 SK 516
            .|
Worm   527 KK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	52/236 (22%)
ugt-13	NP_504317.2	egt	1..509	CDD:223071	122/564 (22%)
ugt-13	NP_504317.2	UDPGT	29..514	CDD:278624	113/534 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48043
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100