DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt305A1 and ugt-7

DIOPT Version :9

Sequence 1:	NP_001261394.1	Gene:	Ugt305A1 / 59217	FlyBaseID:	FBgn0042179	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_504343.2	Gene:	ugt-7 / 182577	WormBaseID:	WBGene00015739	Length:	530	Species:	Caenorhabditis elegans

Alignment Length:	544	Identity:	111/544 - (20%)
Similarity:	210/544 - (38%)	Gaps:	126/544 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 DALLANGHSLLVI-----------STAPNPEPKKQVDGLVYYHLPNEYDVMKRHFLLEEPREYIS 97
            |.|..:||.::|.           ....||:.|     ::.|    |.:...:.|....|:..::
Worm    38 DTLADHGHEVVVFQQQIVEALRDKKVIKNPDIK-----IINY----EANTAGKEFYRNRPKSSVT 93

  Fly    98 MV-TLNQLLVWYEVLLGSCRALLNSDTMSSKRPELTAQL-----------SMEYDLIITD----- 145
            .. |.||       ......|...::.||.....:..|:           |..:|:::.:
Worm    94 KYWTTNQ-------AANPSAADQFAEAMSKDLEHMCLQVFEDKSLHTMLKSEHFDVLLAEPFDPC 151

  Fly   146 ---------VTQGIECLMDSVSGWRSKPV---LGLSAGKLTPDLMSLLRAENTINAARIPHYISQ 198
                     :...|..:..|    |..||   ||..:|               :|.  ||...|:
Worm   152 GLYLGDYLKIPSTIVAMASS----RIDPVQWALGQPSG---------------LNF--IPGPDSK 195

  Fly   199 VPKTMGFWNRLHNHIMYYAEPLIHLVITRPVLSEL-MKT------------ENAFPKLQLVLLNT 250
            ..:..|.|:|::|..|::....:...:...:|.:| .||            |:|:     :..|:
Worm   196 YGEESGVWDRINNVWMFFMRTRMFRAVYWNLLDKLRFKTGLEIRNIDEIVAESAY-----LFYNS 255

  Fly   251 HPTLDYVQNLPPGVIEVGGLHIKN---QTSPLPTYIQEFTEK--------FFDGIVYINMPYIEY 304
            :|.||:........:.:||..:..   ::..||..::...:|        |...|...:||. ||
Worm   256 NPYLDFPFPSLTKCVPIGGFSMNTTNWKSENLPENLKNILQKRPNTVFISFGSVIRSADMPQ-EY 319

  Fly   305 MNDQGLKAMYTMIHGNPNVAFIWNV--EQLEQLPAKKPNLLTLHVNQSLQQD-ILAMQYVKGFLN 366
            .|     |:..:.....:|.|||..  |:.|::....|.  .:|:.:.|.|. :||...|..|:.
Worm   320 KN-----AIIEVTKLMSDVTFIWKYEDEKDEEMRGNIPE--NVHLMKWLPQPALLADSRVSLFIT 377

  Fly   367 HGDSFSLQEAIHYGVPVVVLPLKLEEFNNAQRVMERNLG--VMLQVKEFNQSSLSDALTRILDEE 429
            ||...|:.|..:.|.|.:|:||..::..|.: ::.|:.|  |..:.:..|...|...:..::...
Worm   378 HGGLGSIMEVAYSGKPAIVIPLFFDQPMNGE-MLRRHGGAEVYSKFELSNAKKLKKVIQNMIQNP 441

  Fly   430 RFISALHQAQLKFRTRPQSALELAVWHAEQLIAEPRLFKHFAQTETLAQ--NFFVANSLDVLTVP 492
            ::::...:.....:.:|.:.:|..|.||| ..||   ||...:.:..::  |||....||::...
Worm   442 KYLANAKKLSNLLQKQPINPIERLVKHAE-FAAE---FKKLPELDPYSRHLNFFQFFFLDIVATL 502

  Fly   493 LIVLLAAVVSLANLVYVLYTGGSK 516
            ||:.:.:.:.:..:.||:.:..||
Worm   503 LILFMLSALFVYWITYVICSVRSK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	52/234 (22%)
ugt-7	NP_504343.2	egt	1..477	CDD:223071	99/493 (20%)
ugt-7	NP_504343.2	UDPGT	27..521	CDD:278624	109/537 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010