DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt305A1 and ugt-46

DIOPT Version :9

Sequence 1:	NP_001261394.1	Gene:	Ugt305A1 / 59217	FlyBaseID:	FBgn0042179	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_508112.1	Gene:	ugt-46 / 180404	WormBaseID:	WBGene00015141	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	554	Identity:	104/554 - (18%)
Similarity:	198/554 - (35%)	Gaps:	113/554 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VFVLLGRFCSLEAANILCLVSTAKHNNPGWSKP-------LFDALLANGHSLLVISTAPNPEPKK 66
            :||||..|.:...:..:.:.|      |..||.       |.|.|...||.:.|:
Worm     4 IFVLLATFVNAAFSYKILVFS------PATSKSHLISNGRLADELARAGHDVTVL---------- 52

  Fly    67 QVDGLVYYHLPNEYDVMKRHFL--LEEPREYISMVTLNQLLVWYEVLLGSCRALLNSDTMSSKRP 129
            ::|.|......|...|.|:..:  .:|...:            ..||.|....::       :.|
Worm    53 ELDFLGISQTTNSVKVAKKRIIDGFQESTNF------------KNVLHGFSETVM-------EEP 98

  Fly   130 ELTAQLS--MEYDLIITDVTQGIECLMDSVSGWRSKPVLGLSAGKLTPDLMSLLRAENTINAARI 192
            ..|.::.  ..|..:..|:......:.|..:..::....|..|.::.      |......:|..|
Worm    99 SFTDEIKGWWAYQNVYNDLCAEFLKMDDIFNELKNAKFDGFFAEQIN------LCGFGYAHALEI 157

  Fly   193 PHY--ISQVP---------------KTMGFWNRLHNHIMY--YAEPLIHLVITRPVLSELMKTEN 238
            |.:  ||..|               .|:.|...|.....|  .|..|...|:|:...:.|.....
Worm   158 PRHFLISSCPFAAPVYDFTGLPMPTSTVAFAADLSISPTYTERARNLFVAVLTKLEFTLLNNRLQ 222

  Fly   239 A---------FPKL-------QLVLLNTHPTLDYVQNLPPGVIEVGGLHIKNQTSPLPTYIQEFT 287
            |         ||.|       .::.:.|...:|........::.||||.:.:..:.:........
Worm   223 AHFQHKFGEHFPSLYSVTSDVDVIFVATDEIIDISTTTLQNIVHVGGLGVDDDVAEMDNVFASEM 287

  Fly   288 EKFFDGIVYINMPYIEYMNDQGLKAMYT---MIHGNPNVAFIWNVEQLEQLPAKKPNLLTLHVNQ 349
            .|..:|::|.::..|........|.|.|   ::...|:..|:        :.|.|.:|.|....:
Worm   288 SKGKEGVIYFSLGTIANTTKIDSKVMRTVLDIVKKFPDYHFV--------IRADKYDLSTREYAK 344

  Fly   350 SL----------QQDILAMQYVKGFLNHGDSFSLQEAIHYGVPVVVLPLKLEEFNNAQRVMERNL 404
            |:          |..||....:|.|:.|....|:.||...|||::.:|...::..|::.|.::..
Worm   345 SVSNAFVSDWLPQPAILHHPRLKLFITHSGYNSIVEAARAGVPLINIPFMFDQNLNSRAVEKKGW 409

  Fly   405 GVMLQVKEF--NQSSLSDALTRILDEERFISALHQAQLKFRTRPQSALELAVWHAEQLIAEPRLF 467
            |:....|:.  ....:..|::.|:..:::.....:.:...:::|.|:.:|.:...|..|....|.
Worm   410 GIRRHKKQLLTEPEEIEKAISEIIHNKKYSLKAQRIRDLIKSKPLSSSQLLIKTTEWAIKNHGLD 474

  Fly   468 KHFAQTETLAQNFFVANSLDVLTVPLIVLLAAVV 501
            :  .:.|:..|..:...:|||: :|:..|..::|
Worm   475 E--IKFESRGQTTWTYYNLDVI-IPVFWLSISLV 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	44/240 (18%)
ugt-46	NP_508112.1	UDPGT	19..527	CDD:278624	99/539 (18%)
ugt-46	NP_508112.1	egt	<213..503	CDD:223071	57/300 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48043
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	3.060