DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt305A1 and ugt-9

DIOPT Version :9

Sequence 1:	NP_001261394.1	Gene:	Ugt305A1 / 59217	FlyBaseID:	FBgn0042179	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_504312.1	Gene:	ugt-9 / 178883	WormBaseID:	WBGene00020587	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	573	Identity:	122/573 - (21%)
Similarity:	225/573 - (39%)	Gaps:	141/573 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 NP--GWSKPLFDALLAN-----GHSLLVISTAPNPEPKKQVDGLV---------YYHLPNEYDVM 83
            ||  |:|...|.:.|||     ||::.|..  |.....|..|||:         ||  |:.|..:
Worm    25 NPIFGYSHAKFVSQLANIIADHGHNVTVFQ--PFHIALKNTDGLIKNKNIEIINYY--PDHYAEL 85

  Fly    84 KRHFLLEEPREYISMVTLNQLLVWYEVLLGSCRALLNSDTMSSKRPELTAQL-----------SM 137
            .:......|..:.|.:..|.:|          .:.|....:..:..:.|.||           :.
Worm    86 LKKKTPTFPDFWDSHLMNNPVL----------SSFLMPKALGGEFEQTTTQLFQDQKILNDLKNR 140

  Fly   138 EYDLIITDVTQGIECLMDSVSGWRSKPVLGLSAGKLTPDLMSLLRAENTINAA--------RIPH 194
            .:|:::.:..:        ::|:....:|.:.:   .| |||.:|.. .|::|        ..|.
Worm   141 NFDVLLAETFE--------IAGFYIADLLEIPS---IP-LMSAVRLP-IIDSAFGQPSILGYFPQ 192

  Fly   195 YISQVPKTMG------------FWNRLHNHIMYYAEPLIHLVITRPV--LSELMKTENAFPKLQL 245
            ..|:|....|            |||.....:..:....|...|..||  ..:|:|      :..:
Worm   193 QYSKVAPEAGFLDRLNDLYRIFFWNLTTQRLCQFQNDFIQKAIGHPVPHWRDLVK------ESPI 251

  Fly   246 VLLNTHPTLDYVQNLPPGVIEVGGLHIKNQTSPLPTYIQEFTEKF------FDGIVYINMPYI-- 302
            .:.|::..||:.......::.|||:.|..:..   .::...||::      .:..|:|:...:
Worm   252 YITNSNSYLDFAVPTTATIVHVGGITIDLEKM---RHVAALTEEYENILAERESTVFISFGSVIR 313

  Fly   303 EYMNDQGLKA-MYTMIHGNPNVAFIWNVEQLEQLPAKKPNLL--TLHVNQSL-QQDILAMQYVKG 363
            .|......|| :..|....|:|.|||..|:.:   .|..|.|  .:|:.:.: |..:||.:.||.
Worm   314 SYEMPDNFKAGIIKMFKSLPDVTFIWKYEKDD---VKFQNRLPKNVHLKKWVPQPSLLADKRVKL 375

  Fly   364 FLNHGDSFSLQEAIHYGVPVVVLPLKLEEFNNAQRVMERNLGVMLQVKEFNQSSLSDA--LTRIL 426
            |:.||...|..|..:.|.|.:::|:..::.|||. ::.|:.|.:    .:::..|:|.  ||:.:
Worm   376 FVTHGGLGSTMEVAYTGKPALMVPIFGDQPNNAD-MLARHGGAV----AYDKFDLADGEKLTKTV 435

  Fly   427 DEERFISALHQAQLKFRTRPQSALEL-----------AVWHAEQLIAEPRLFKHFAQTETLAQNF 480
            .:       .....|:....|..|::           .:.|.|..:..|   ||.:|...:.:..
Worm   436 RD-------MVTNSKYEVNAQELLKVLSKQPIDPKLNLMKHLEFAMEFP---KHRSQVPAINRTG 490

  Fly   481 FVAN-SLDVLTVPLIVLLAAVVSLANLVYVLYTGGSKRQQTLEKAV-LKKRKK 531
            .:|: .|||:.|   :.||::..|    :|::    |....|.|.: |:|.|:
Worm   491 LIAHYYLDVIGV---LTLASIFGL----FVIF----KILNILRKMISLRKVKR 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	52/243 (21%)
ugt-9	NP_504312.1	egt	20..462	CDD:223071	101/487 (21%)
ugt-9	NP_504312.1	UDPGT	30..532	CDD:278624	118/566 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48043
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100