DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt305A1 and ugt-62

DIOPT Version :9

Sequence 1:	NP_001261394.1	Gene:	Ugt305A1 / 59217	FlyBaseID:	FBgn0042179	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_497918.1	Gene:	ugt-62 / 175591	WormBaseID:	WBGene00010904	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	548	Identity:	122/548 - (22%)
Similarity:	216/548 - (39%)	Gaps:	116/548 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 LLAN-GHSLLVISTAPNPE-------PKK--------QVDGLVYYHLPNEYD--VMKRHFLLEEP 92
            :||| ||.:.:|..:..|:       ||.        .|:||....|..|..  :.|...|.:.|
Worm    40 VLANGGHDVTMIHLSHLPDYKTDVKIPKNIKVHRVEAYVEGLTKALLEKEQSAFIFKDTGLKDMP 104

  Fly    93 REYISMVTLNQLLVWYEVLLGSCRALL-NSDTMSSKRPELTAQLSMEYDLIITDVTQGIECLMDS 156
                  ..::....:.::....||.:: |.:.|.....|   :..:.|..|.:....|: .....
Worm   105 ------AMMSMFSRFGKMFQDGCRNIVRNKEFMKWLENE---KFDVAYSYIYSSCPIGL-IHAAK 159

  Fly   157 VSGWRSKPVLGLSAGKLTPDLMSLLRAENTINAARIPHYI----SQVPKTMGFWNRLHNHIMYYA 217
            :..|     :.|::|.|. |.::     .|:....||.|:    .:....|||:.|:.:.|.:..
Worm   160 IPSW-----VWLNSGALM-DFVA-----ETVGVPIIPSYVPPLMMESDDEMGFFFRMKSFIGHTL 213

  Fly   218 EPLIHLVITRPVLSELMKTE---NAFP-------KLQLVLLNTHPTLDYVQNLPPGVIEVGGLHI 272
            ..::|..:|....:::.:.|   ..||       |..||::|::...|..:.....|:.:|||.:
Worm   214 MTVLHRRMTSNGETQIFRDELNDPNFPHTMDLGAKCPLVIVNSNELYDLPRPTLAKVVNIGGLGV 278

  Fly   273 K-NQTSPLPTYIQEFTEKFFDGIVYI--------NMPYIEYMNDQGLKAMYTMIHGNPNVAFIW- 327
            . :...||....::.:|.....||:.        :|| :|:.|.. |:|..::    |:..|:.
Worm   279 GFDSAKPLTGEFKKISETGKGMIVFSFGSVAAAHDMP-LEWKNSI-LEAFSSL----PDYQFLMR 337

  Fly   328 ------------NVEQLEQLPAKKPNLLTLHVNQSLQQDILAMQYVKGFLNHGDSFSLQEAIHYG 380
                        ||...:.||               |:|:|.....|.|:.||...|:||||..|
Worm   338 YVADDLNDRLPKNVHLFKWLP---------------QKDLLLHNKTKAFITHGGYNSMQEAISAG 387

  Fly   381 VPVVVLPLKLEEFNNAQRVMERNLGVMLQVKEFNQSSLSDALTRILDEERFISALHQAQLKFRTR 445
            ||:|.:.|..::..|::...:....|.:|..|.::.::..|:..|::.:.:...:.:.....|.:
Worm   388 VPLVTIALFGDQPKNSKVAKKHGFAVNIQKGEISKKTIVKAIMEIVENDSYKQKVSRLSAMVRAQ 452

  Fly   446 PQSALE-LAVWHAEQLIAEPRLFKHFAQTETLAQ--NFFVANSLDVLTVPLIVLLAAVVSLANLV 507
            |....| |..|  .:.:||   ||.....|...|  |||..:||||:|...||:.
Worm   453 PMKPAERLLKW--SEFLAE---FKTLDNLEPAGQKLNFFQYHSLDVITFLFIVIF---------- 502

  Fly   508 YVLYTGGSKRQQTLEKAVLKK-RKKSKK 534
            .|.|.|....:..:.....|| ..|:||
Worm   503 IVFYIGYRFMRAVIRCCFCKKCETKTKK 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	54/241 (22%)
ugt-62	NP_497918.1	UDPGT	37..520	CDD:278624	117/536 (22%)
ugt-62	NP_497918.1	egt	<251..471	CDD:223071	55/245 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010