DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt305A1 and ugt-58

DIOPT Version :9

Sequence 1:	NP_001261394.1	Gene:	Ugt305A1 / 59217	FlyBaseID:	FBgn0042179	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_496059.2	Gene:	ugt-58 / 174507	WormBaseID:	WBGene00009450	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	567	Identity:	117/567 - (20%)
Similarity:	216/567 - (38%)	Gaps:	127/567 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VLLGRFCSLEAANILCLVSTAKHNNPGWSKPLFDALLANGHSLLVISTAPNPEPKKQVDGLVYYH 75
            :|||....:.|.::|.:.||....:......|...|...||.:..:...|     ::.|.:::..
Worm     6 LLLGTIGWVTAGDVLFIPSTLYPVHAQTMSVLARELAERGHKVTWLEIGP-----ERSDIVLHQQ 65

  Fly    76 LPNEYDVMKRHF---LLEEPREYISMVTLNQL------------LVWYEVLLGSCRALLNSDTMS 125
            :..|:  ....|   .|:|..::.:..:.::|            ..|    |.|.|  |....:|
Worm    66 VSREF--WPAQFGDRTLQEIYQFKNHTSHSELWNPQYTNENEQTTGW----LASIR--LCDSVLS 122

  Fly   126 SKRPELTAQLSMEYD-LIITDVTQGIECLMDSV----------------SGWRSK--------PV 165
            ..:.:....:..::. :|:.|:......||..:                |.|.::        ||
Worm   123 RSKSKFDKMVEKQFSTVIVDDLYNSCGVLMAGLKKSVYIYWSMTGLRTESAWANQSPSPPSYLPV 187

  Fly   166 LGLSAGKLTPDLMSLLRAENTINAARIPHYISQVPKTMGFWNRLHNHIMYYAEPLIHLVITRPVL 230
            .|..   ||.||.                          |..||:|...|:.:..||..|.:|.:
Worm   188 AGTG---LTDDLT--------------------------FSQRLYNVASYFKQLYIHQHIVQPRI 223

  Fly   231 SELMK-----TENAFP---KLQLVLLNTHPTLDYVQNLPPGVIEVGGLHIKNQTSPLPTYIQEFT 287
            ..:.:     .|:.|.   ...:..:||.|..|:.:...|.|..:|.:..: :...||.....:.
Worm   224 DAVFQKYYPGVESTFEIERNASINFVNTPPIFDFSRPYMPRVNFIGAIQCR-KPKELPKEFTSWI 287

  Fly   288 EKFFDGIVYINMPYIEYMN---DQGLKAMYTMIHGNPNVAFIW--NVEQLEQLPAKKPNLLTLHV 347
            ..:.||.|.::..:....|   :...:|........||:.|||  .:.....||:   |||   |
Worm   288 SAYPDGFVVLSTGFTVQWNKSPEHIRQAYLDTFKYLPNLLFIWQTGLPNSSNLPS---NLL---V 346

  Fly   348 NQSLQ-QDILAMQYVKGFLNHGDSFSLQEAIHYGVPVVVLPLKLEEFNNAQRVMERNLGVMLQVK 411
            ...|. ||:|..|..:..::||...|:.|::::|||||.:||....::|..|:..|:.|||::..
Worm   347 KPWLPLQDLLGHQKCRCHVSHGGLNSVIESVYHGVPVVGVPLTSRGYDNLLRITARDSGVMVEKS 411

  Fly   412 EFNQSSLSDALTRILDEERF---------------ISALHQAQ--LKFRTRPQSALELAVWHAEQ 459
            ||:...|:.|:..:::.|::               .:.|:.|.  ::|..|.|.     |.||..
Worm   412 EFSGEILTAAINEVIENEKYKKEMLIFQDMVIDVPYTELYHAAFWVEFIERHQE-----VPHARS 471

  Fly   460 LIAEPRLFKHFAQTETLAQNFFVA-NSLDVLTVPLIVLLAAVVSLAN 505
             .|:...|..:...:.:|..|||. .:|.::...:..:...:.|:.|
Worm   472 -GADHLNFLQYFLVDVIAFFFFVIFCTLSIIYYTIRTVFRTIRSVVN 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	60/241 (25%)
ugt-58	NP_496059.2	UDPGT	17..485	CDD:278624	106/522 (20%)
ugt-58	NP_496059.2	Glycosyltransferase_GTB_type	<200..462	CDD:299143	65/268 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010