DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt305A1 and UGT2A1

DIOPT Version :9

Sequence 1:	NP_001261394.1	Gene:	Ugt305A1 / 59217	FlyBaseID:	FBgn0042179	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001376494.1	Gene:	UGT2A1 / 10941	HGNCID:	12542	Length:	737	Species:	Homo sapiens

Alignment Length:	528	Identity:	116/528 - (21%)
Similarity:	209/528 - (39%)	Gaps:	128/528 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 KPLFDALLANGHSLLVISTA------PNPE------------PKKQVDGLVYY-------HLPNE 79
            |.:.:.|:...|::.|::::      .||:            .|..:|.|:.:       |.|..
Human   247 KIILEELIQRNHNVTVLASSATLFINSNPDSPVNFEVIPVSYKKSNIDSLIEHMIMLWIDHRPTP 311

  Fly    80 YDVMKRHFLLEEPREYISMVTLNQLL-VWYEVLLGSCRALLNSDTMSSKRPELTAQLSM-EYDLI 142
            ..:..  |..|          |.:|| .::::.:..|..:|       |.|:|.|:|.. .:|::
Human   312 LTIWA--FYKE----------LGKLLDTFFQINIQLCDGVL-------KNPKLMARLQKGGFDVL 357

  Fly   143 ITDVTQGIECLMDSVSGWRSKPVL---GLSAGKLTPDLMSLLR--AENTI--NAARIPHYISQVP 200
            :.|                  ||.   .|.|.||....|..||  ..:|:  :..:||..:|.||
Human   358 VAD------------------PVTICGDLVALKLGIPFMYTLRFSPASTVERHCGKIPAPVSYVP 404

  Fly   201 KT-------MGFWNRLHNHIMYYAEPLI------------HLVITRP-VLSELMKTENAFPKLQL 245
            ..       |.|..|:.|.|.|..:..|            ..::.|| .|.|.|      .|.::
Human   405 AALSELTDQMTFGERIKNTISYSLQDYIFQSYWGEWNSYYSKILGRPTTLCETM------GKAEI 463

  Fly   246 VLLNTHPTLDYVQNLPPGVIEVGGLHIKNQTSPLPTYIQEFTEKF-FDGIVYINM-PYIEYMNDQ 308
            .|:.|:...::.:...|....|||||.| ...|||..::||.:.. .:|:|..:: ..::.:.::
Human   464 WLIRTYWDFEFPRPYLPNFEFVGGLHCK-PAKPLPKEMEEFIQSSGKNGVVVFSLGSMVKNLTEE 527

  Fly   309 GLKAMYTMIHGNPNVAFIWNVEQLEQLPAKKPNLLTLHVNQSL-----QQDILAMQYVKGFLNHG 368
            ....:.:.:...|. ..:|..:      .|||  .||..|..|     |.|:|.....|.|:.||
Human   528 KANLIASALAQIPQ-KVLWRYK------GKKP--ATLGNNTQLFDWIPQNDLLGHPKTKAFITHG 583

  Fly   369 DSFSLQEAIHYGVPVVVLPLKLEEFNNAQRVMERNLGVMLQVKEFNQSSLSDALTRILDEERF-- 431
            .:..:.|||::|||:|.:|:..::.:|...:..:...|.:.:.......|..||..:::|..:
Human   584 GTNGIYEAIYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKE 648

  Fly   432 ----ISALHQAQLKFRTRPQSALELAVWHAEQLIAEPRLFKHFAQTETLAQNFFVANSLDVLTVP 492
                :|.:|..|      |...|:.||:..| .:...:..||. :.......:|..:||||:...
Human   649 NAMRLSRIHHDQ------PVKPLDRAVFWIE-FVMRHKGAKHL-RVAAHDLTWFQYHSLDVIGFL 705

  Fly   493 LIVLLAAV 500
            |:.:..|:
Human   706 LVCVTTAI 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	55/231 (24%)
UGT2A1	NP_001376494.1	UDPGT	237..725	CDD:278624	116/528 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150219
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940