Protein Alignment Ugt305A1 and UGT2A1

DIOPT Version :10

• Sequence 1: NP_652703.1
• Gene: Ugt305A1 / 59217
• FlyBaseID: FBgn0042179
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_001376494.1
• Gene: UGT2A1 / 10941
• HGNCID: 12542
• Length: 737
• Species: Homo sapiens
• Alignment Length: 528
• Identity: 116/528 - (21%)
• Similarity: 209/528 - (39%)
• Gaps: 128/528 - (24%)

  Fly    40 KPLFDALLANGHSLLVISTA------PNPE------------PKKQVDGLVYY-------HLPNE 79
            |.:.:.|:...|::.|::::      .||:            .|..:|.|:.:       |.|..
Human   247 KIILEELIQRNHNVTVLASSATLFINSNPDSPVNFEVIPVSYKKSNIDSLIEHMIMLWIDHRPTP 311

  Fly    80 YDVMKRHFLLEEPREYISMVTLNQLL-VWYEVLLGSCRALLNSDTMSSKRPELTAQLSM-EYDLI 142
            ..:..  |..|          |.:|| .::::.:..|..:|       |.|:|.|:|.. .:|::
Human   312 LTIWA--FYKE----------LGKLLDTFFQINIQLCDGVL-------KNPKLMARLQKGGFDVL 357

  Fly   143 ITDVTQGIECLMDSVSGWRSKPVL---GLSAGKLTPDLMSLLR--AENTI--NAARIPHYISQVP 200
            :.|                  ||.   .|.|.||....|..||  ..:|:  :..:||..:|.||
Human   358 VAD------------------PVTICGDLVALKLGIPFMYTLRFSPASTVERHCGKIPAPVSYVP 404

  Fly   201 KT-------MGFWNRLHNHIMYYAEPLI------------HLVITRP-VLSELMKTENAFPKLQL 245
            ..       |.|..|:.|.|.|..:..|            ..::.|| .|.|.|      .|.::
Human   405 AALSELTDQMTFGERIKNTISYSLQDYIFQSYWGEWNSYYSKILGRPTTLCETM------GKAEI 463

  Fly   246 VLLNTHPTLDYVQNLPPGVIEVGGLHIKNQTSPLPTYIQEFTEKF-FDGIVYINM-PYIEYMNDQ 308
            .|:.|:...::.:...|....|||||.| ...|||..::||.:.. .:|:|..:: ..::.:.::
Human   464 WLIRTYWDFEFPRPYLPNFEFVGGLHCK-PAKPLPKEMEEFIQSSGKNGVVVFSLGSMVKNLTEE 527

  Fly   309 GLKAMYTMIHGNPNVAFIWNVEQLEQLPAKKPNLLTLHVNQSL-----QQDILAMQYVKGFLNHG 368
            ....:.:.:...|. ..:|..:      .|||  .||..|..|     |.|:|.....|.|:.||
Human   528 KANLIASALAQIPQ-KVLWRYK------GKKP--ATLGNNTQLFDWIPQNDLLGHPKTKAFITHG 583

  Fly   369 DSFSLQEAIHYGVPVVVLPLKLEEFNNAQRVMERNLGVMLQVKEFNQSSLSDALTRILDEERF-- 431
            .:..:.|||::|||:|.:|:..::.:|...:..:...|.:.:.......|..||..:::|..:
Human   584 GTNGIYEAIYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKE 648

  Fly   432 ----ISALHQAQLKFRTRPQSALELAVWHAEQLIAEPRLFKHFAQTETLAQNFFVANSLDVLTVP 492
                :|.:|..|      |...|:.||:..| .:...:..||. :.......:|..:||||:...
Human   649 NAMRLSRIHHDQ------PVKPLDRAVFWIE-FVMRHKGAKHL-RVAAHDLTWFQYHSLDVIGFL 705

  Fly   493 LIVLLAAV 500
            |:.:..|:
Human   706 LVCVTTAI 713

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_652703.1	GT1_Gtf-like	22..460	CDD:340817	107/486 (22%)
UGT2A1	NP_001376494.1	UDPGT	237..725	CDD:278624	116/528 (22%)