Protein Alignment Ugt305A1 and UGT2B11

DIOPT Version :9

• Sequence 1: NP_001261394.1
• Gene: Ugt305A1 / 59217
• FlyBaseID: FBgn0042179
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_001064.1
• Gene: UGT2B11 / 10720
• HGNCID: 12545
• Length: 529
• Species: Homo sapiens
• Alignment Length: 564
• Identity: 121/564 - (21%)
• Similarity: 224/564 - (39%)
• Gaps: 125/564 - (22%)

  Fly     9 VFVLLGRFCSLEAANILC---LVSTAKHNNPGW--SKPLFDALLANGHSLLVISTA--------- 59
            |.:|:...|...:.:  |   ||..|::::  |  .|.:...|:..||.:.|::::
Human     8 VLLLIHLSCYFSSGS--CGKVLVWAAEYSH--WMNMKTILKELVQRGHEVTVLASSASILFDPND 68

  Fly    60 ---------PNPEPKKQVDGLVYYHLPNEYDVMKRHFLLEEPREYISMVTLNQLLVW--YEVLLG 113
                     |....|.:.:.::...:....|:.|..|.|     |.|.   .|.::|  |::...
Human    69 ASTLKFEVYPTSLTKTEFENIIMQQVKRWSDIRKDSFWL-----YFSQ---EQEILWELYDIFRN 125

  Fly   114 SCRALLNSDTMSSKRPELTAQLSMEYDLIITDVT----QGIECLMD--SVSGWRSKPVLGL---S 169
            .|:     |.:|:|:.....|.| .:|::..|..    :.:..|::  .|...|..|...:   |
Human   126 FCK-----DVVSNKKVMKKLQES-RFDIVFADAVFPCGELLAALLNIRFVYSLRFTPGYTIERHS 184

  Fly   170 AGKLTPDLMSLLRAENTINAARIPHYISQVPKTMGFWNRLHNHI------------------MYY 216
            .|.:.|             .:.||..:|::...|.|..|:.|.|                  .:|
Human   185 GGLIFP-------------PSYIPIVMSKLSDQMTFMERVKNMIYVLYFDFWFQMSDMKKWDQFY 236

  Fly   217 AEPLIHLVITRPVLSELMKTENAFPKLQLVLLNTHPTLDYVQNLPPGVIEVGGLHIKNQTSPLPT 281
            :|     |:.||  :.|.:|   ..|..:.|:....:..:.....|.|..|||.|.| ...|||.
Human   237 SE-----VLGRP--TTLFET---MGKADIWLMRNSWSFQFPHPFLPNVDFVGGFHCK-PAKPLPK 290

  Fly   282 YIQEFTEKFFD-GIVYINM-PYIEYMNDQGLKAMYTMIHGNPNVAFIWNVEQLEQLPAKKPNLLT 344
            .::||.:...: |:|..:: ..|..|..:....:.|.:...|. ..:|..:      ..||:.|.
Human   291 EMEEFVQSSGENGVVVFSLGSVISNMTAERANVIATALAKIPQ-KVLWRFD------GNKPDALG 348

  Fly   345 LHVNQSL-----QQDILAMQYVKGFLNHGDSFSLQEAIHYGVPVVVLPLKLEEFNNAQRVMERNL 404
            |  |..|     |.|:|.....:.|:.||.:..:.|||::|:|:|.:||..::.:|...:..:..
Human   349 L--NTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGA 411

  Fly   405 GVMLQVKEFNQSSLSDALTRILDEERF---ISALHQAQLKFRTRPQSALELAVWHAEQLIAEPRL 466
            .|.|.....:.:.|.:||..::::..:   |..|.:.|   ..:|...|:.||:..| .:...:.
Human   412 AVRLDFNTMSSTDLLNALKTVINDPLYKENIMKLSRIQ---HDQPVKPLDRAVFWIE-FVMPHKG 472

  Fly   467 FKHFAQTETLAQNFFVANSLDVLTVPLIVLLAAVVSLANLVYVL 510
            .||. :.......:|..:||||:.    .|||.|   |.:::::
Human   473 AKHL-RVAAHDLTWFQYHSLDVIG----FLLACV---ATVIFII 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	55/228 (24%)
UGT2B11	NP_001064.1	UDPGT	24..525	CDD:278624	117/546 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150545
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940