Protein Alignment Ugt305A1 and UGT2B11

DIOPT Version :10

• Sequence 1: NP_652703.1
• Gene: Ugt305A1 / 59217
• FlyBaseID: FBgn0042179
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_001064.1
• Gene: UGT2B11 / 10720
• HGNCID: 12545
• Length: 529
• Species: Homo sapiens
• Alignment Length: 564
• Identity: 121/564 - (21%)
• Similarity: 224/564 - (39%)
• Gaps: 125/564 - (22%)

  Fly     9 VFVLLGRFCSLEAANILC---LVSTAKHNNPGW--SKPLFDALLANGHSLLVISTA--------- 59
            |.:|:...|...:.:  |   ||..|::::  |  .|.:...|:..||.:.|::::
Human     8 VLLLIHLSCYFSSGS--CGKVLVWAAEYSH--WMNMKTILKELVQRGHEVTVLASSASILFDPND 68

  Fly    60 ---------PNPEPKKQVDGLVYYHLPNEYDVMKRHFLLEEPREYISMVTLNQLLVW--YEVLLG 113
                     |....|.:.:.::...:....|:.|..|.|     |.|.   .|.::|  |::...
Human    69 ASTLKFEVYPTSLTKTEFENIIMQQVKRWSDIRKDSFWL-----YFSQ---EQEILWELYDIFRN 125

  Fly   114 SCRALLNSDTMSSKRPELTAQLSMEYDLIITDVT----QGIECLMD--SVSGWRSKPVLGL---S 169
            .|:     |.:|:|:.....|.| .:|::..|..    :.:..|::  .|...|..|...:   |
Human   126 FCK-----DVVSNKKVMKKLQES-RFDIVFADAVFPCGELLAALLNIRFVYSLRFTPGYTIERHS 184

  Fly   170 AGKLTPDLMSLLRAENTINAARIPHYISQVPKTMGFWNRLHNHI------------------MYY 216
            .|.:.|             .:.||..:|::...|.|..|:.|.|                  .:|
Human   185 GGLIFP-------------PSYIPIVMSKLSDQMTFMERVKNMIYVLYFDFWFQMSDMKKWDQFY 236

  Fly   217 AEPLIHLVITRPVLSELMKTENAFPKLQLVLLNTHPTLDYVQNLPPGVIEVGGLHIKNQTSPLPT 281
            :|     |:.||  :.|.:|   ..|..:.|:....:..:.....|.|..|||.|.| ...|||.
Human   237 SE-----VLGRP--TTLFET---MGKADIWLMRNSWSFQFPHPFLPNVDFVGGFHCK-PAKPLPK 290

  Fly   282 YIQEFTEKFFD-GIVYINM-PYIEYMNDQGLKAMYTMIHGNPNVAFIWNVEQLEQLPAKKPNLLT 344
            .::||.:...: |:|..:: ..|..|..:....:.|.:...|. ..:|..:      ..||:.|.
Human   291 EMEEFVQSSGENGVVVFSLGSVISNMTAERANVIATALAKIPQ-KVLWRFD------GNKPDALG 348

  Fly   345 LHVNQSL-----QQDILAMQYVKGFLNHGDSFSLQEAIHYGVPVVVLPLKLEEFNNAQRVMERNL 404
            |  |..|     |.|:|.....:.|:.||.:..:.|||::|:|:|.:||..::.:|...:..:..
Human   349 L--NTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGA 411

  Fly   405 GVMLQVKEFNQSSLSDALTRILDEERF---ISALHQAQLKFRTRPQSALELAVWHAEQLIAEPRL 466
            .|.|.....:.:.|.:||..::::..:   |..|.:.|   ..:|...|:.||:..| .:...:.
Human   412 AVRLDFNTMSSTDLLNALKTVINDPLYKENIMKLSRIQ---HDQPVKPLDRAVFWIE-FVMPHKG 472

  Fly   467 FKHFAQTETLAQNFFVANSLDVLTVPLIVLLAAVVSLANLVYVL 510
            .||. :.......:|..:||||:.    .|||.|   |.:::::
Human   473 AKHL-RVAAHDLTWFQYHSLDVIG----FLLACV---ATVIFII 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_652703.1	GT1_Gtf-like	22..460	CDD:340817	106/499 (21%)
UGT2B11	NP_001064.1	UDPGT	24..525	CDD:278624	117/546 (21%)