DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt305A1 and Ugt2b34

DIOPT Version :9

Sequence 1:	NP_001261394.1	Gene:	Ugt305A1 / 59217	FlyBaseID:	FBgn0042179	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_705826.1	Gene:	Ugt2b34 / 100727	MGIID:	2140962	Length:	532	Species:	Mus musculus

Alignment Length:	607	Identity:	141/607 - (23%)
Similarity:	234/607 - (38%)	Gaps:	159/607 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRALCLLPVFVLLGRFCSLEAANILCLVSTAKHNNPGW--SKPLFDALLANGHSLLVISTAPNPE 63
            |.|..||.:..|.|.|.|.....:|.......|    |  .|.:.|.||..||.::|:  .|:..
Mouse     5 MTAALLLLLLQLSGFFGSGTGGKVLVWPMEFSH----WLNLKTILDELLKKGHEVMVL--RPSAS 63

  Fly    64 PKKQVD---GLVYYHLPNEYDVMK---------RHFLLEEPRE----YISMVTLNQLLVW----- 107
            ...:||   .:.:...|..|.:.:         :.::.|.|::    |..|:   |.:||
Mouse    64 LSYEVDNTSAIEFETYPTSYSLSELEEIFWESLKKYIYELPKQSFWGYFLML---QEMVWVDSKY 125

  Fly   108 YEVLLGSCRALLNSDTMSSKRPELTAQL-SMEYDLIITDVTQGIEC-----------LMDSVSGW 160
            :|.|   |:     |.:.:|  ||..:| ...:|:|:.|  ..|.|           |:.|:..:
Mouse   126 FESL---CK-----DVVFNK--ELMTKLQKSRFDVILAD--PFIPCGDLLAEVLKIPLVYSLRFF 178

  Fly   161 RSKPVLGLSAGKLTPDLMSLLRAENTINAARIPHYISQVPKTMGFWNRLHNHIMY---------- 215
            ........|.|...|             .:.:|..:|::...|.|..|:.| ::|
Mouse   179 PGSTYEKYSGGLPLP-------------PSYVPVVMSELSDRMTFMERVRN-VIYMLCFDFWFQT 229

  Fly   216 ---------YAEPLIHLVITRP-VLSELMKTENAFPKLQLVLLNTHPTLDYVQNLPPGVIEVGGL 270
                     |.|     |:.|| .|||.|      .|..:.|:.|:..|::...:.|....:|||
Mouse   230 FNEKNWNQLYTE-----VLGRPTTLSETM------AKADIWLIRTYWDLEFPHPVLPNFDFIGGL 283

  Fly   271 HIKNQTSPLPTYIQEFTEKFFD-GIVYINMPYIEYMNDQGLKAMYTMIHGNPNVAFIWNVEQ--L 332
            |.: ...|||..|::|.:...: |:|..::        ..:....|....|...|.:..:.|  |
Mouse   284 HCR-PAKPLPKEIEDFVQSSGEHGVVVFSL--------GSMVGSITEERANVIAAGLAQIPQKVL 339

  Fly   333 EQLPAKKPNLLTLHVNQSL-----QQDILAMQYVKGFLNHGDSFSLQEAIHYGVPVVVLPLKLEE 392
            .:...|||.  ||..|..|     |.|:|.....:.|:.||.:..:.|||::|:|||.:||..::
Mouse   340 WRFEGKKPE--TLGSNTRLYKWIPQNDLLGHSKTRAFITHGGTNGIYEAIYHGIPVVGIPLFGDQ 402

  Fly   393 FNNAQRVMERNLGVMLQVKEFNQSSLSDALTRILDEERF------ISALHQAQLKFRTRPQSALE 451
            ::|...:..:...|.|.....:.:.|..||..:.::..:      :|.:|..|      |...|:
Mouse   403 YDNIVHLKAKGAAVRLDFLTMSSTDLHTALKTVTNDPSYKENAMRLSRIHHDQ------PVKPLD 461

  Fly   452 LAVWHAEQLIAEPRLFKHFAQTETLAQNFFVA---------NSLDVLTVPLIVLLAAVVSLANLV 507
            .||:..|           |......|::..||         :|||||.    .|||.|::   ::
Mouse   462 RAVFWIE-----------FVMRHKGAKHLRVAAHDLSWVQYHSLDVLG----FLLACVLT---VM 508

  Fly   508 YVLYTGGSKRQQTLEKAVLKKR 529
            ::|........|.|.||..||:
Mouse   509 FILKKCCLFCCQKLTKAGRKKK 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	57/232 (25%)
Ugt2b34	NP_705826.1	UDPGT	27..529	CDD:278624	131/582 (23%)
Ugt2b34	NP_705826.1	egt	<272..510	CDD:223071	66/272 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840561
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48043
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.030