DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt305A1 and ugt1b5

DIOPT Version :9

Sequence 1:	NP_001261394.1	Gene:	Ugt305A1 / 59217	FlyBaseID:	FBgn0042179	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001170813.1	Gene:	ugt1b5 / 100384899	ZFINID:	ZDB-GENE-080227-14	Length:	528	Species:	Danio rerio

Alignment Length:	540	Identity:	124/540 - (22%)
Similarity:	225/540 - (41%)	Gaps:	144/540 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 WS--KPLFDALLANGHSLLVISTAPNPEPKKQVDGLVYYHLPNEYDVMKRHFLLEEPREYISMVT 100
            |:  |.:.:.:...||:::|:.    ||...::.       |.::.:.|:.     |.:|...|
Zfish    42 WTGVKAVAEEMGRRGHTVIVVI----PEISMRLG-------PGKHYITKKF-----PVKYKPDV- 89

  Fly   101 LNQLLVWYEVLLGSCRALLNSDTMSSKRPELTAQLS---------MEYDLIITD----VTQGIEC 152
            |||::.          .|:|  |:|:....|..:::         ::|.:..|:    ..:.||.
Zfish    90 LNQMIA----------KLVN--TLSAPEQSLLKRVTSNIYNFGKVVDYFISTTESLFQEQELIEF 142

  Fly   153 L----MDSVSGWRSKPVLGLSAGKLTPDLMSLLR---AENTINA-----ARIPHYISQVPKTMGF 205
            |    .|:|....:.|...:.|..|:...:.:||   .|:...|     :.||...:|....|.|
Zfish   143 LRDQNFDAVLTDPAMPTGAILAYNLSVPAVYMLRGLMCESKATACPDPPSYIPRLFTQNSDHMNF 207

  Fly   206 WNRLHNHIMYYAEPL----------------IHLVITRPVLSELMKTENAFPKLQLVLLNTHPTL 254
            ..||.|.:....|||                :|..::   ::|::.|...:      |:....||
Zfish   208 GERLMNTLASLMEPLMCKLKFSAFEEVTSKFLHRDVS---MTEILSTGAVW------LMRYDFTL 263

  Fly   255 DYVQNLPPGVIEVGGLHIKNQTSPLPTYIQEFTE--------KFFDGIVYINMPYIEYMNDQGLK 311
            ::.:.|.|.:..:||::.: ..:||...::||..        .|..|.:..:||  :...|...|
Zfish   264 EFPKPLMPNITNIGGINCE-VNNPLTKEVEEFVNGSGEHGIVVFSLGSLVSSMP--KEKADIFFK 325

  Fly   312 AMYTMIHGNPNVAFIW------------NVEQLEQLPAKKPNLLTLHVNQSLQQDILAMQYVKGF 364
            | ::||   |. ..:|            ||:.::.||               |.|:|.....:.|
Zfish   326 A-FSMI---PQ-RVLWRYTGEIPNNVPENVKLMKWLP---------------QNDLLGHPKARAF 370

  Fly   365 LNHGDSFSLQEAIHYGVPVVVLPLKLEEFNNAQRVMERNLGVMLQVKEFNQSSLSDALTRILDEE 429
            :.||.:..:.|.|.:|||:|:|||..::.:|..||..|.:||:|.:.:....:|.|||..:::..
Zfish   371 ITHGGTHGIYEGICHGVPMVMLPLFGDQADNVHRVATRGVGVILSIHDITVETLLDALNSVINNS 435

  Fly   430 RF------ISALHQAQLKFRTRPQSALELAVWHAEQLIAEPRLFKHF--AQTETLAQNFFVANSL 486
            .:      :||:|      ..||...|:|||:..| .:...:...|.  |..|.   |:...:||
Zfish   436 SYKQKMQKLSAIH------NDRPIQPLDLAVFWTE-FVMRHKGADHLRPAAHEL---NWLQYHSL 490

  Fly   487 DVLTVPLIVLLAAVVSLANL 506
            ||:...|:::|  :|:||.|
Zfish   491 DVIGFMLLIVL--IVTLAML 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	62/244 (25%)
ugt1b5	NP_001170813.1	UDPGT	30..524	CDD:278624	124/540 (23%)
ugt1b5	NP_001170813.1	egt	<268..507	CDD:223071	71/273 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584831
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930