DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt305A1 and ugt5e1

DIOPT Version :9

Sequence 1:	NP_001261394.1	Gene:	Ugt305A1 / 59217	FlyBaseID:	FBgn0042179	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_005166829.1	Gene:	ugt5e1 / 100002993	ZFINID:	ZDB-GENE-081105-106	Length:	590	Species:	Danio rerio

Alignment Length:	561	Identity:	137/561 - (24%)
Similarity:	234/561 - (41%)	Gaps:	138/561 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LFDALLANGHSLLVISTAPN---PEPKKQVDGLVYY--HLPNEYDVMKRHFLLEEPREYISMVTL 101
            |...|...||.|.|:.:|.:   ||.......:...  ||.:          ||:|:...|.:..
Zfish   100 LLQELHQRGHKLTVVRSANSWYIPENATHYTSITIQVNHLSS----------LEDPKYMASFLKR 154

  Fly   102 N------QLLVW-YEVLLGSCRALLNSDTMSSKRPELTAQL---------------SMEYDLIIT 144
            |      :..:| :..|......||.....|      ||::               ..:|||::|
Zfish   155 NIDIQRGKGSIWSFLALQKEIITLLEESHRS------TAEMVRVVLEDEKLIKTLKESKYDLMLT 213

  Fly   145 DVTQGIECLMDSVSGWRSKPVLGLSAG-KLTPDLMSLLRAENTINAARIP-HYI----SQVPKTM 203
            |            .|:....:||...| .:..::..:..||.....|..| .||    |:|...|
Zfish   214 D------------PGFAGGVILGAYLGLPMVFNVRWITNAEGHFAIAPSPLSYIPTIGSRVTDKM 266

  Fly   204 GFWNRLHNHIMYYAEPLIHLVITRP----VLSELM-KTENAFPKLQ---LVLLNTHPTLDYVQNL 260
            .|.|:|.|.:.:.....|..::|||    |:|:.: ...|.:..:|   |.|:.    :|:|...
Zfish   267 SFANKLKNIMHFGIGQYIDHMLTRPLYQGVISKYIDPNTNVYALIQGADLWLMR----VDFVFEF 327

  Fly   261 P----PGVIEVGGLHIKNQTSPLPTYIQEFTEKFFD-GIVYINMPYIEYMNDQGLKAMYTMIHGN 320
            |    |.|:.:||...| .:.|||..:.:|.|...: |:|.:::..:          :.:::
Zfish   328 PRPTMPNVVYIGGFQCK-PSKPLPDELNKFVESSGEHGVVIMSLGTL----------LGSLV--- 378

  Fly   321 PNVAFIWNVEQLEQLPAK--------KPNLL---TLHVNQSLQQDILAMQYVKGFLNHGDSFSLQ 374
            |:::.| ......|||.|        ||:.|   ||.|:...|.|:|.....|.|:.||.:..:.
Zfish   379 PDISEI-VASAFAQLPQKVIWRHVGEKPSTLGNNTLVVDWLPQNDLLGHPKTKAFVTHGGTNGIY 442

  Fly   375 EAIHYGVPVVVLPLKLEEFNNAQRVMERNLGVMLQVKEFNQSSLSDALTRILDEE-------RFI 432
            |||::|||::.|||..::|:|..|:..|.:..||.|...:...|:.||..||||:       |.:
Zfish   443 EAIYHGVPMLGLPLIFDQFDNIIRLEARGVARMLDVATLDVDILTQALKDILDEKQSYQKNMRKM 507

  Fly   433 SALHQAQLKFRTRPQSALELAVWHAEQLIAEPRLFKH----FAQTETLAQNFFVANSLDVLTVPL 493
            |:||      |..|...|:.|::..|.::      :|    ..:||:....::..:.||||
Zfish   508 SSLH------RDTPLKPLDSAIFWLEFVM------RHKGAAHLRTESYKLPWYSYHCLDVL---- 556

  Fly   494 IVLLAAVVSLANLVYVLYTGGSKRQQTLEKAVLKKRKKSKK 534
             .|:.::.:.|.|:.:|.:      :.|.:|.::|.|..|:
Zfish   557 -ALIMSLCTAAGLLLILIS------RALLRACVRKIKAKKE 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	69/244 (28%)
ugt5e1	XP_005166829.1	UDPGT	82..586	CDD:278624	135/555 (24%)
ugt5e1	XP_005166829.1	egt	<324..550	CDD:223071	68/252 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584426
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.940