Protein Alignment Apl and KAP123

DIOPT Version :10

• Sequence 1: NP_730182.1
• Gene: Apl / 59216
• FlyBaseID: FBgn0042178
• Length: 1080
• Species: Drosophila melanogaster
• Sequence 2: NP_011035.1
• Gene: KAP123 / 856846
• SGDID: S000000912
• Length: 1113
• Species: Saccharomyces cerevisiae
• Alignment Length: 1183
• Identity: 254/1183 - (21%)
• Similarity: 480/1183 - (40%)
• Gaps: 197/1183 - (16%)

  Fly     1 MEAAILDIINGILTIDTERIRESTAKMLKA--YENPDSLLVLTQIVMSDRPVQERQVAAVLLKRR 63
            :|..:..|.:|:      .::|:| |.|:.  |..|.:|..|..|:.:......:|:|.|..::.
Yeast     9 LEQTLHAITSGV------GLKEAT-KTLQTQFYTQPTTLPALIHILQNGSDDSLKQLAGVEARKL 66

  Fly    64 VKKLRHWQLVPAEHQAAIKSNMLQVLIAVKEKTVKGTVAFIIGSLVRHEEGEQNSWREEILKFIY 128
            |.|  ||..:....:|:||:::||...:..::.|:.:.|.:|.| :..||.:.|.| .:::..:.
Yeast    67 VSK--HWNAIDESTRASIKTSLLQTAFSEPKENVRHSNARVIAS-IGTEELDGNKW-PDLVPNLI 127

  Fly   129 ERCSSPDPIESERGSSIFSSLMDAAPDQFSDHTDTMFPLLAGILVTAEANGNMATPTVHNMLTGS 193
            :..|..|....:....|..||::......|.|.|....|.         :..:..|:...:.:.|
Yeast   128 QTASGEDVQTRQTAIFILFSLLEDFTSSLSGHIDDFLALF---------SQTINDPSSLEIRSLS 183

  Fly   194 CFLLPFVSGHSNAEQIV--------VKAVPLILKALAAFVEKGYSI------EFMGAFDIIDSMA 244
            ...|..||.....::.:        ..::|.::..|.|.::...::      ..:..|.::||.
Yeast   184 AQALNHVSALIEEQETINPVQAQKFAASIPSVVNVLDAVIKADDTMNAKLIFNCLNDFLLLDSQ- 247

  Fly   245 EHVPHLLTGN-VKLLLEFCLMIARNKQFDASIRVQVLTFVGSLVRLKKKIIMKQKLLQPTLSV-L 307
                  |||| :..|::..|.||.|.:.|..:||..|.|:.|.:..:|..:.:.| |.|.::| .
Yeast   248 ------LTGNFIVDLIKLSLQIAVNSEIDEDVRVFALQFIISSLSYRKSKVSQSK-LGPEITVAA 305

  Fly   308 FEVICQD---DLEEGDDDYFSSESLSSPSNAAAQTLDLMALHMVPDKFIPPLLDLLEPALQSPEP 369
            .:|.|::   |.|..::|.......::||::|.:.|...:..:.|.:....:::.:...|||...
Yeast   306 LKVACEEIDVDDELNNEDETGENEENTPSSSAIRLLAFASSELPPSQVASVIVEHIPAMLQSANV 370

  Fly   370 VLRRSSFICMGVIAEGCSEAIGKKYLEVMLNIIKAGVLDSVMFVRTAAFFALGQFSEFLQPTICK 434
            ..||:..:.:.|...|..:.|..::.:::...|. |:.|:...|:.||...:.|.:..||..:.|
Yeast   371 FERRAILLAISVAVTGSPDYILSQFDKIIPATIN-GLKDTEPIVKLAALKCIHQLTTDLQDEVAK 434

  Fly   435 FAPQILPVLFDYLNQLVLELKVGEPDSKHMDRMFY---ALETFCENLDED-IVPYLPTLMDRLFG 495
            |..:.||::.|.::           .:|::....|   ||:...|.:..| |..||..||::||.
Yeast   435 FHEEYLPLIIDIID-----------SAKNIVIYNYATVALDGLLEFIAYDAIAKYLDPLMNKLFY 488

  Fly   496 VMEPQNSNQMREMALSAIAAVSAAAKENLMPYFPRIMTVLQGCLVKDCPK-EMYSQ-----RIQA 554
            ::|...|:::|...:|||.:.:.||....:|||...:..|:. .:::|.: |..|:     |...
Yeast   489 MLESNESSKLRCAVVSAIGSAAFAAGSAFIPYFKTSVHYLEK-FIQNCSQIEGMSEDDIELRANT 552

  Fly   555 IDTLAALCRELGKDNIIPLADDTMNFCLMMLEDGPDDPEYRRSIYNLMSSLSSVVNESMASVFPK 619
            .:.::.:.|.:..|.....|:..:|.....::  .|....|.|.|..:::|:.|..|:.|.....
Yeast   553 FENISTMARAVRSDAFAEFAEPLVNSAYEAIK--TDSARLRESGYAFIANLAKVYGENFAPFLKT 615

  Fly   620 FIDRIMESVIFSEDMVPNVSDNADDDLALVDAPDIEIDLEHTDDEDDQDAYPVENDYIVEKEEAI 684
            .:..|.:::...|... |...:|:|..|..|:         .::|:.|:.:.|......|||.|.
Yeast   616 ILPEIFKTLELDEYQF-NFDGDAEDLAAFADS---------ANEEELQNKFTVNTGISYEKEVAS 670

  Fly   685 LSLKEFATHTGAAFAPYLQSAFENVYKMIDHPQGDVRMACIDSICSFITAL---HKLDDAAGLKR 746
            .:|.|.|..|...|.||::.:.:.:.:.:|...| :|...:::|.:.:.::   .|::..:..|
Yeast   671 AALSELALGTKEHFLPYVEQSLKVLNEQVDESYG-LRETALNTIWNVVKSVLLASKVEPESYPK- 733

  Fly   747 ACEIAIPKFAHIMRTDDQVAVVLRMLDV----LYDVFKYVPAIN-SQEHAELI--FGCI------ 798
                .||..:::  ..|.:||:....:.    |.|.|:....|. .::.|.:|  ||.|
Yeast   734 ----GIPASSYV--NADVLAVIQAARETSMGNLSDEFETSMVITVMEDFANMIKQFGAIIIMDNG 792

  Fly   799 ------------RDIFTNKMACQ-FNEESGGGDDECSEESENDEMLFENA--------------- 835
                        ..:......|| .:.|.....||..:.||.:..|.:.|
Yeast   793 DSSMLEALCMQVLSVLKGTHTCQTIDIEEDVPRDEELDASETEATLQDVALEVLVSLSQALAGDF 857

  Fly   836 ANLFPMFGLTLQPELFSLYFGRLYHFYIQRLAKVKERDLPEQRAYIYGALADCCKALKGCCATYF 900
            |.:|..|    :|.:|.|:         |..:|.|       |:...||.::....:|.......
Yeast   858 AKVFDNF----RPVVFGLF---------QSKSKNK-------RSSAVGAASELALGMKEQNPFVH 902

  Fly   901 DALRPIFIAGSRDSDAKARQNSYFALGEIVFHSEEKSFESYPTILQALSEAI------------- 952
            :.|..:.|..:.|...:.|.|:.:.:|.:..::.......|..:|:||.|.:
Yeast   903 EMLEALVIRLTSDKSLEVRGNAAYGVGLLCEYASMDISAVYEPVLKALYELLSAADQKALAAEDD 967

  Fly   953 --VRESVPAAMDNICGAVARLIVTNPDSVPLGQVLPVWLNHLPLKDDTVENDVIQKAFRVLYLKA 1015
              .||.:..|..|..|.|||:.:.|...|||.|.:|..|.||||.....|.:.|.:....||.:.
Yeast   968 EATREIIDRAYANASGCVARMALKNSALVPLEQTVPALLAHLPLNTGFEEYNPIFELIMKLYQEN 1032

  Fly  1016 RPSIEAHLEQILAITIEASYK----------------------RQMPDVETTESAVALIKEIRAN 1058
            .|.|.....:|:.|......|                      :|....|.....:.|:|.:...
Yeast  1033 SPVITNETPRIIEIFSAVFTKENDRIKLEKESTLGREENMERLKQFQTEEMKHKVIELLKYLNTT 1097

  Fly  1059 YPELFSKVSNMNP 1071
            |..:.::    ||
Yeast  1098 YNGIVAQ----NP 1106

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Apl	NP_730182.1	IBN_N	29..90	CDD:197981	17/62 (27%)
		KAP95	<304..703	CDD:227540	95/412 (23%)
		HEAT repeat	356..384	CDD:293787	6/27 (22%)
		HEAT repeat	397..427	CDD:293787	7/29 (24%)
		HEAT repeat	438..473	CDD:293787	7/37 (19%)
KAP123	NP_011035.1	IBN_N	25..92	CDD:197981	20/69 (29%)
		HEAT repeat	40..65	CDD:293787	6/24 (25%)
		HEAT repeat	77..111	CDD:293787	9/34 (26%)
		HEAT repeat	121..151	CDD:293787	5/29 (17%)
		HEAT repeat	162..189	CDD:293787	4/35 (11%)
		HEAT repeat	352..385	CDD:293787	6/32 (19%)
		HEAT repeat	397..427	CDD:293787	7/30 (23%)
		HEAT repeat	438..468	CDD:293787	7/40 (18%)
		HEAT repeat	479..506	CDD:293787	9/26 (35%)