Protein Alignment Apl and IPO4

DIOPT Version :10

• Sequence 1: NP_730182.1
• Gene: Apl / 59216
• FlyBaseID: FBgn0042178
• Length: 1080
• Species: Drosophila melanogaster
• Sequence 2: NP_078934.3
• Gene: IPO4 / 79711
• HGNCID: 19426
• Length: 1081
• Species: Homo sapiens
• Alignment Length: 1088
• Identity: 317/1088 - (29%)
• Similarity: 557/1088 - (51%)
• Gaps: 77/1088 - (7%)

  Fly     1 MEAAILD-IINGILTIDTERIRESTAKMLKAYENPDSLLVLTQIVMSDRPVQERQVAAVLLKRRV 64
            ||:|.|: ::..:|..||||||.:|.::......|.:|..|..::.|....|.||.||||.:||:
Human     1 MESAGLEQLLRELLLPDTERIRRATEQLQIVLRAPAALPALCDLLASAADPQIRQFAAVLTRRRL 65

  Fly    65 KKLRHWQLVPAEHQAAIKSNMLQVLIAVKEKTVKGTVAFIIGSLVRHEEGEQNSWREEILKFIYE 129
            .  ..|:.:.||.:.::||.:|..|....|..|..::|.:..::.|.|..|  :| .::|:.:..
Human    66 N--TRWRRLAAEQRESLKSLILTALQRETEHCVSLSLAQLSATIFRKEGLE--AW-PQLLQLLQH 125

  Fly   130 RCSSPDPIESERGSSIFSSLMDAAPDQFSDHTDTMFPLLAGILVTAEANGNMATPTVHNMLTGSC 194
            ...||...|.|.|..:.|.::.:.|:.|..|...:..||      .|..|.:.:|   .:|..|.
Human   126 STHSPHSPEREMGLLLLSVVVTSRPEAFQPHHRELLRLL------NETLGEVGSP---GLLFYSL 181

  Fly   195 FLLPFVSGHSNAEQIVV--KAVPLILKALAAF--VEKGYSIEFMGAFDIIDSMAEHVPHLLTGNV 255
            ..|..::.:.:.|.:.:  ..||.::.|:...  :::..:.|   |.:.:|.:.|....::|..:
Human   182 RTLTTMAPYLSTEDVPLARMLVPKLIMAMQTLIPIDEAKACE---ALEALDELLESEVPVITPYL 243

  Fly   256 KLLLEFCLMIARNKQFDASIRVQVLTFVGSLVRLKKKIIMKQKLLQPTLSVLFEVIC------QD 314
            ..:|.|||.:|||.....:||:::|..:..||::|.|.::|.:||.|.|..||.::.      |.
Human   244 SEVLTFCLEVARNVALGNAIRIRILCCLTFLVKVKSKALLKNRLLPPLLHTLFPIVAAEPPPGQL 308

  Fly   315 DLEEGDDDYFSSESL------SSPSNAAAQTLDLMALHMVPDKFIPPLLDLLEPALQSPEPVLRR 373
            |.|:.|.:   .|.|      .:|.:.|.|.:|::|||:.|:|..|.|:.:||.||:|..|..|:
Human   309 DPEDQDSE---EEELEIELMGETPKHFAVQVVDMLALHLPPEKLCPQLMPMLEEALRSESPYQRK 370

  Fly   374 SSFICMGVIAEGCSEAIGKKYLEVMLNIIKAGVLDSVMFVRTAAFFALGQFSEFLQPTICKFAPQ 438
            :..:.:.|:::|..:.|.::.|..:|.|:..|:.|....||.||.||||||||.|||.|..::.:
Human   371 AGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFALGQFSENLQPHISSYSRE 435

  Fly   439 ILPVLFDYLNQLVLELKVGEPDSKHMDRMFYALETFCENLDEDIVPYLPTLMDRLFGVMEPQNSN 503
            ::|:|..||..:.|      ..:.|:.:..||||.|.|||...:.||||.||:.:..::...:|.
Human   436 VMPLLLAYLKSVPL------GHTHHLAKACYALENFVENLGPKVQPYLPELMECMLQLLRNPSSP 494

  Fly   504 QMREMALSAIAAVSAAAKENLMPYFPRIMTVLQGCLVKDCPKEMYSQRIQAIDTLAALCRELGKD 568
            :.:|:|:||:.|::.||:.:|:||||.||..|:..|:.. .:::...:||:::||..|.|.:| :
Human   495 RAKELAVSALGAIATAAQASLLPYFPAIMEHLREFLLTG-REDLQPVQIQSLETLGVLARAVG-E 557

  Fly   569 NIIPLADDTMNFCLMM---LEDGPDDPEYRRSIYNLMSSLSSVVNESMASVFPKFIDRIMESVIF 630
            .:.|||::    |..:   |.|..|||:.||..|:|.::||.::.|.:|....:....::.|:..
Human   558 PMRPLAEE----CCQLGLGLCDQVDDPDLRRCTYSLFAALSGLMGEGLAPHLEQITTLMLLSLRS 618

  Fly   631 SEDMVPNVSDNADDDLALVDAPDIEIDLEHTD----DEDDQD--AYPVENDYIVEKEEAILSLKE 689
            :|.:||.. |.:...|...|..|.|.:.|..|    :|||.:  .|.|||.:..|||:...::.|
Human   619 TEGIVPQY-DGSSSFLLFDDESDGEEEEELMDEDVEEEDDSEISGYSVENAFFDEKEDTCAAVGE 682

  Fly   690 FATHTGAAFAPYLQSAFENVYKMIDHPQGDVRMACIDSICSFITALHKL-------DDAAGLKRA 747
            .:.:|..||.||::|.||.|:|:::.|..:||.|..:::..|..||||.       .:.|.|:.|
Human   683 ISVNTSVAFLPYMESVFEEVFKLLECPHLNVRKAAHEALGQFCCALHKACQSCPSEPNTAALQAA 747

  Fly   748 CEIAIPKFAHIMRTDDQVAVVLRMLDVLYDVFKYVPAINSQEHAEL--IFGCIRDIFTNKMACQF 810
            ....:|.:...:..:.:..||:.:|:.|..|.:....:..:....|  :.|.::.:...|.|||.
Human   748 LARVVPSYMQAVNRERERQVVMAVLEALTGVLRSCGTLTLKPPGRLAELCGVLKAVLQRKTACQD 812

  Fly   811 NEESGGGDDECSEESENDEMLFENAANLFPMFGLTLQPELFSLYFGRLYHFYIQRLAKVKERDLP 875
            .:|.  .::|..:::|.|.||.|:|....|........:.|:.:|.   .|....:.|.|:....
Human   813 TDEE--EEEEDDDQAEYDAMLLEHAGEAIPALAAAAGGDSFAPFFA---GFLPLLVCKTKQGCTV 872

  Fly   876 EQRAYIYGALADCCKALKGCCATYFDALRPIFIAGSRDSDAKARQNSYFALGEIVFHSEEKSFES 940
            .::::..|.||:..:.|....|.:...|.|:.::.::::|.:.|.|:.|.:|.:..|....:.|.
Human   873 AEKSFAVGTLAETIQGLGAASAQFVSRLLPVLLSTAQEADPEVRSNAIFGMGVLAEHGGHPAQEH 937

  Fly   941 YPTILQALSEAIVRESVPAAMDNICGAVARLIVTNPDSVPLGQVLPVWLNHLPLKDDTVENDVIQ 1005
            :|.:|..|...:.||......||||||:|||::.:|...|..|||...|:.||||:|..|...|.
Human   938 FPKLLGLLFPLLARERHDRVRDNICGALARLLMASPTRKPEPQVLAALLHALPLKEDLEEWVTIG 1002

  Fly  1006 KAFRVLYLKARPSIEAHLEQILAI-TIEASYKRQMPDVETTESAVALI 1052
            :.|..||..:...:.....::|.| ::..:..:..||   |::|:.|:
Human  1003 RLFSFLYQSSPDQVIDVAPELLRICSLILADNKIPPD---TKAALLLL 1047

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Apl	NP_730182.1	IBN_N	29..90	CDD:197981	19/60 (32%)
		KAP95	<304..703	CDD:227540	139/419 (33%)
		HEAT repeat	356..384	CDD:293787	9/27 (33%)
		HEAT repeat	397..427	CDD:293787	15/29 (52%)
		HEAT repeat	438..473	CDD:293787	9/34 (26%)
IPO4	NP_078934.3	IBN_N	24..90	CDD:197981	21/67 (31%)
		HEAT 1	348..385		12/36 (33%)
		HEAT repeat	353..381	CDD:293787	9/27 (33%)
		KAP95	<357..>620	CDD:227540	93/274 (34%)
		HEAT 2	390..427		18/36 (50%)
		HEAT repeat	394..424	CDD:293787	15/29 (52%)
		HEAT 3	431..471		14/45 (31%)
		HEAT repeat	435..464	CDD:293787	9/34 (26%)
		HEAT 4	475..513		14/37 (38%)
		HEAT repeat	477..507	CDD:293787	9/29 (31%)
		HEAT repeat	519..551	CDD:293787	10/32 (31%)
		HEAT 5	895..932		8/36 (22%)
		HEAT 6	936..974		15/37 (41%)