Protein Alignment Apl and Ipo4

DIOPT Version :10

• Sequence 1: NP_730182.1
• Gene: Apl / 59216
• FlyBaseID: FBgn0042178
• Length: 1080
• Species: Drosophila melanogaster
• Sequence 2: NP_077229.4
• Gene: Ipo4 / 75751
• MGIID: 1923001
• Length: 1082
• Species: Mus musculus
• Alignment Length: 1094
• Identity: 306/1094 - (27%)
• Similarity: 550/1094 - (50%)
• Gaps: 88/1094 - (8%)

  Fly     1 MEAAILD-IINGILTIDTERIRESTAKMLKAYENPDSLLVLTQIVMSDRPVQERQVAAVLLKRRV 64
            ||.|.|: |:..:|..||||||.:|.::.....:|.:|..|..::.:....|.||.||||.:||:
Mouse     1 MEPAGLEQILKELLLPDTERIRRATEQLQTILRDPAALPALFDLLATATDSQIRQFAAVLTRRRL 65

  Fly    65 KKLRHWQLVPAEHQAAIKSNMLQVLIAVKEKTVKGTVAFI--IGSLVRHEEGEQNSWREEILKFI 127
            .  ..|:.:..|.:.::||   .||.|::::||......:  :.:.:..:||.| .|.:.:....
Mouse    66 N--NRWRRLAPEQRESLKS---LVLTALQKETVHSVSVSLAQLSATIFRKEGLQ-GWPQFMNLLQ 124

  Fly   128 YERCSSPDPIESERGSSIFSSLMDAAPDQFSDHTDTMFPLLAGILVTAEANGNMATPTVHNMLTG 192
            :...||..| |.|.|..:.|.::.:.|:.|..|...:..||         |..::..:...:|..
Mouse   125 HSTHSSHSP-EKEVGLLLLSVVVSSQPEAFHAHQHELLQLL---------NETLSDVSFPGVLFY 179

  Fly   193 SCFLLPFVSGHSNAEQIVV--KAVPLILKALAAFVEKGYSIEFMGAFDIIDSMAEHVPHLLTGNV 255
            |...|..::.:...:.:.:  ..||.::.||...:... .::...|.:.:|.|.|....::..::
Mouse   180 SLRTLTAIARYVRPDDVSLARMLVPKVVTALRTLIPLD-EVKACEALEALDEMLETELPIINPHL 243

  Fly   256 KLLLEFCLMIARNKQFDASIRVQVLTFVGSLVRLKKKIIMKQKLLQPTLSVLFEVIC-------- 312
            ..:|.|||.:|:|......:||:||..:..||::|.|.::|.:|:.|.|..||.::.
Mouse   244 SEVLTFCLEVAKNVALGEPLRVRVLCCLTFLVKVKSKALLKNRLVPPLLHALFPLMAAEPPMGQL 308

  Fly   313 -QDDLEEGDDDYFSSESLSSPSNAAAQTLDLMALHMVPDKFIPPLLDLLEPALQSPEPVLRRSSF 376
             .:|.:..|||........:|.:.|.|.:|::|||:.|:|..|.::.:||.||:|.:|..|::.|
Mouse   309 DPEDQDSDDDDLEIGLMGETPKHFAVQVVDMLALHLPPEKLCPHVMPMLEEALRSEDPYQRKAGF 373

  Fly   377 ICMGVIAEGCSEAIGKKYLEVMLNIIKAGVLDSVMFVRTAAFFALGQFSEFLQPTICKFAPQILP 441
            :.:.|:::|..:.|.::.|..:|.|:..|:.|....||.||.||||||||.|||.|..::.:::|
Mouse   374 LVLAVLSDGAGDHIRQRLLYPLLQIVCKGLDDPSQIVRNAALFALGQFSENLQPHISSYSEEVMP 438

  Fly   442 VLFDYLNQLVLELKVGEPDSKHMDRMFYALETFCENLDEDIVPYLPTLMDRLFGVMEPQNSNQMR 506
            :|..||..:.:      .::.|:.:..||||.|.|||...:.||||.||:.:...::..:..:.:
Mouse   439 LLLSYLKSVPM------GNTHHLAKACYALENFVENLGPKVQPYLPELMECMLQPLKNPSKARTK 497

  Fly   507 EMALSAIAAVSAAAKENLMPYFPRIMTVLQGCLVKDCPKEMYSQRIQAIDTLAALCRELGKDNII 571
            |:|:|||.|::.||:::|:||||.||.:|:..|:.. .::.:..:||:::||..|.|.|| :::.
Mouse   498 ELAVSAIGAIATAAQDSLLPYFPTIMDLLREFLLTG-HEDFHLVQIQSLETLGVLARALG-ESMK 560

  Fly   572 PLADDT----MNFCLMMLEDGPDDPEYRRSIYNLMSSLSSVVNESMASVFPKFIDRIMESVIFSE 632
            |||::.    :..|:.:     |||:.||..|:|.::||.::.|.:....|:....::.|:..:|
Mouse   561 PLAEECCQLGLGLCIHI-----DDPDVRRCTYSLFAALSGLMGEGLGPYLPQITTLMLLSLRSTE 620

  Fly   633 DMVPNVSDNA-----DDDLALVDAPDI-EIDLEHTDDEDDQDAYPVENDYIVEKEEAILSLKEFA 691
            .:||.....:     |||....:..:: :.|:|...|:.:...|.|||.:..|||:...:|.|.:
Mouse   621 GIVPQYDGISSFLLFDDDSEAEEEEELMDEDMEEEGDDSEISGYSVENAFFDEKEDTCTALGEIS 685

  Fly   692 THTGAAFAPYLQSAFENVYKMIDHPQGDVRMACIDSICSFITALHKLDDAAG--------LKRAC 748
            .:|..||.|::.:.|:.|||:::.|..:||.:..:::..|..||||....:.        |:.:.
Mouse   686 MNTCVAFLPFMDATFDEVYKLLECPHMNVRKSAYEALGQFCCALHKASQRSSSDPSSSPVLQTSL 750

  Fly   749 EIAIPKFAHIMRTDDQVAVVLRMLDVLYDVFKYVPAINSQEHAELIFGC--IRDIFTNKMACQFN 811
            ...:|.:...::.:.:..||:.:|:.|..|.:...::..|....|...|  ::.:...|.|||..
Mouse   751 ARVMPAYMQAVKVERERPVVMAVLESLTGVLRTCGSLALQPPGRLSELCNVLKAVLQKKTACQDA 815

  Fly   812 EESGGGDDECSEESENDEMLFENAANLFPMFGLTLQPELFSLYFGRLYHFYIQRLAKVKERDLPE 876
            ||.   |||..:::|.|.||.|:|....|:...|.....|:.:|..   |....|.|.|:.....
Mouse   816 EED---DDEDDDQAEYDAMLLEHAGEAIPVLAATAGGHAFAPFFAT---FLPLLLCKTKQSCTVA 874

  Fly   877 QRAYIYGALADCCKALKGCCATYFDALRPIFIAGSRDSDAKARQNSYFALGEIVFHSEEKSFESY 941
            ::::..|.||:..:.|....|.:...|.|:.:..:|::|.:.|.|:.|.||.:..|....:.:.:
Mouse   875 EKSFAVGTLAESIQGLGTASAQFVSRLFPVLLNNAREADPEVRSNAIFGLGVLAEHGGCPAQDHF 939

  Fly   942 PTILQALSEAIVRESVPAAMDNICGAVARLIVTNPDSVPLGQVLPVWLNHLPLKDDTVENDVIQK 1006
            |.:|..|...:.||......||||||:||:::.:|......|||...|..||||:|..|...|..
Mouse   940 PKLLGLLLPLLARERHDRVRDNICGALARVLMASPVGKTEPQVLATLLRALPLKEDMEEWLTIGH 1004

  Fly  1007 AFRVLYLKARPSIEAHLEQILAITIE--------ASYKRQMPDVETTESAVALI 1052
            .|..|:       :.:.||::.:..|        ....|..||   |::|:.|:
Mouse  1005 LFSFLH-------QNNPEQVVDVASELLRICSLILPDNRIPPD---TKAALLLL 1048

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Apl	NP_730182.1	IBN_N	29..90	CDD:197981	17/60 (28%)
		KAP95	<304..703	CDD:227540	131/417 (31%)
		HEAT repeat	356..384	CDD:293787	9/27 (33%)
		HEAT repeat	397..427	CDD:293787	15/29 (52%)
		HEAT repeat	438..473	CDD:293787	8/34 (24%)
Ipo4	NP_077229.4	IBN_N	24..90	CDD:197981	20/70 (29%)
		HEAT 1	348..385		12/36 (33%)
		KAP95	<353..>620	CDD:227540	92/279 (33%)
		HEAT repeat	353..381	CDD:293787	9/27 (33%)
		HEAT 2	390..427		18/36 (50%)
		HEAT repeat	394..424	CDD:293787	15/29 (52%)
		HEAT 3	431..471		13/45 (29%)
		HEAT repeat	435..464	CDD:293787	8/34 (24%)
		HEAT 4	475..513		14/37 (38%)
		HEAT repeat	477..507	CDD:293787	9/29 (31%)
		HEAT 5	896..933		10/36 (28%)
		HEAT repeat	901..929	CDD:293787	9/27 (33%)
		HEAT 6	937..975		13/37 (35%)
		HEAT repeat	942..972	CDD:293787	12/29 (41%)