Protein Alignment Apl and ipo4

DIOPT Version :10

• Sequence 1: NP_730182.1
• Gene: Apl / 59216
• FlyBaseID: FBgn0042178
• Length: 1080
• Species: Drosophila melanogaster
• Sequence 2: NP_001008011.2
• Gene: ipo4 / 493373
• XenbaseID: XB-GENE-493034
• Length: 1076
• Species: Xenopus tropicalis
• Alignment Length: 1099
• Identity: 338/1099 - (30%)
• Similarity: 571/1099 - (51%)
• Gaps: 88/1099 - (8%)

  Fly     3 AAILD-IINGILTIDTERIRESTAKMLKAYENPDSLLVLTQIVMSDRPVQERQVAAVLLKRRVKK 66
            |.||: |:..:|..|...|:::||::.:|:::|..:..|..|:...:.:|.||.|||||:||:.|
 Frog     2 AQILETILTSLLQPDNAVIQQATAQLKEAFKDPQIIPALFDILRGSQELQIRQFAAVLLRRRLNK 66

  Fly    67 LRHWQLVPAEHQAAIKSNMLQVLIAVKEKTVKGTVAFIIGSLVRHEEGEQNSWREEILKFIYERC 131
              ||:.:..|.|..:|..:|:.:....|..|:..:|.:|..::::|..|.  | .|.:||:.:..
 Frog    67 --HWKAIQPEQQHNLKIIVLESIQREPEHKVRYALAQLIAVILKNERLEH--W-PEFIKFVLQLS 126

  Fly   132 SSPDPIESERGSSIFSSLMDAAPDQFSDHTDTMFPLLAGILVTAEANGNMATPTVHNMLTGSCFL 196
            .|..|.:.:.|..:....:......|..|...:..|....|.... ||.:...||.::   :| :
 Frog   127 HSDVPDQKQVGILVLWCSLHLKASLFQPHVHDLLGLFKQTLSDLH-NGPLIYYTVQSL---TC-I 186

  Fly   197 LPFVSGHSNAEQIVVKAVPLILKALAAFVE--KGYSIEFMGAFDIIDSMAEHVP---HLLTGNVK 256
            ||::.|  |...::...:|.||.|:...::  :..:.|.|..||::  |.:.||   |.:...|
 Frog   187 LPYIVG--NETNLLRPFIPKILAAIRQLIQVNQVQACEAMEFFDVL--MEDEVPVIVHYIADTV- 246

  Fly   257 LLLEFCLMIARNKQFDASIRVQVLTFVGSLVRLKKKIIMKQKLLQPTLSVLFEVIC--------- 312
               .|||.||.|......:||:.|:.:..|::||.|.|:|||||...|:.||.::|
 Frog   247 ---HFCLEIAVNLGLSDELRVKALSCIMCLIKLKSKSIIKQKLLSQILNSLFPIMCAEPPAGEMD 308

  Fly   313 QDDLEEGDDDYFSSESLSSPSNAAAQTLDLMALHMVPDKFIPPLLDLLEPALQSPEPVLRRSSFI 377
            ::|.|:.|||.  .:|:.:|...|.|.:|::|||:.|:|....|..|:||.|.|..|..|::..:
 Frog   309 KEDQEDEDDDI--EDSVETPKEYAMQVIDMLALHLPPEKLFKELSPLMEPCLLSSNPYQRKAGLM 371

  Fly   378 CMGVIAEGCSEAIGKKYLEVMLNIIKAGVLDSVMFVRTAAFFALGQFSEFLQPTICKFAPQILPV 442
            |:.|::||||:.|..|:|:.||:::...:.|....||.|||:|||||||.|||.|..::..:||:
 Frog   372 CLAVLSEGCSDFICDKHLQPMLSLVCQSLSDDNQVVRNAAFYALGQFSEHLQPDITNYSDTVLPL 436

  Fly   443 LFDYLNQLVLELKVGEPDSKHMDRMFYALETFCENLDEDIVPYLPTLMDRLFGVMEPQNSNQMRE 507
            |.:|.:      :|...::.|:.::||||..|.||||..|.|||||||:|:...:...:||:::|
 Frog   437 LLEYFS------RVDPSNTAHLTKVFYALGNFVENLDGKIEPYLPTLMERILTFLRTSDSNRVKE 495

  Fly   508 MALSAIAAVSAAAKENLMPYFPRIMTVLQGCLVKDCPKEMYSQRIQAIDTLAALCRELGKDNIIP 572
            :::|.:.:::..|.|.|:||||.:|..|:..||:.. :|....:||.:|||..|.|.||||..:|
 Frog   496 LSVSCLGSIANGANELLLPYFPSVMECLKVHLVQTA-EEGRPVQIQCLDTLGILVRTLGKDTFLP 559

  Fly   573 LADDTMNFCLMMLE--DGPDDPEYRRSIYNLMSSLSSVVNESMASVFPKFIDRIMESVIFSEDMV 635
            ||:|.   ||:.|.  |..|||:.|:..|:|.::||.|:.:|:::...|....::.|:...|.:|
 Frog   560 LAEDC---CLLGLGLCDRIDDPDLRQCAYSLFAALSEVMKDSISTHLEKMTTLMVLSLKSKEGVV 621

  Fly   636 PNVSDNA-----DDDLALVDAPDIEI-DLEHTDDEDDQDAYPVENDYIVEKEEAILSLKEFATHT 694
            .:.::|.     ||:   .|..|.|| |.|..:|:.|.:.|.:.|.|:.|||.|.|:|.:.|.:.
 Frog   622 LHYNENRTFLLFDDE---ADEEDTEIEDAEEDEDDPDIEGYTIVNSYVDEKECACLALGDMAYNA 683

  Fly   695 GAAFAPYLQSAFENVYKMIDHPQGDVRMACIDSICSFITALHKL-----DDAAGLKRACEIA--I 752
            .::|.|||.|.|:.|:|.|:....:||.:...::..|:.:::.:     .:|....:.|.::  :
 Frog   684 SSSFFPYLDSCFQEVFKHIEDIHENVRRSAYSALGKFVLSMNLVCQKNPSEANTAAQFCLLSHVM 748

  Fly   753 PKFAHIMRTDDQVAVVLRMLDVLYDVFKYVPAINSQEHAEL--IFGCIRDIFTNKMACQFNEESG 815
            |.:......|.:.|||:.:|:.|.:|.|.:......:..:|  |...|:.:..:|.|||
 Frog   749 PSYLQGALKDKEAAVVMEILEALNEVLKEMKGQCMADAKQLGDICMVIKAVLQSKTACQ------ 807

  Fly   816 GGDDECSEESENDEM-------LFENAANLFPMFGLTLQPELFSLYFGRLYHFYIQRLAKVKERD 873
                :|..|.|:||.       |.|||....|:....:....|:.|||   .|....|.|.|...
 Frog   808 ----DCEAEDEDDEQQAELACRLIENAGEGIPLLATAVGGSTFAPYFG---EFLPLLLNKTKSSC 865

  Fly   874 LPEQRAYIYGALADCCKALKGCCATYFDALRPIFIAGSRDSDAKARQNSYFALGEIVFHSEEKSF 938
            ...::::..|.||:..:||......:...:.|..::.:||...:.|:|:.|.||.:..:......
 Frog   866 TSAEKSFAGGILAESSEALGPAVVQFVPRIFPALLSLARDQHEEVRRNAIFGLGVLAENGGPAMH 930

  Fly   939 ESYPTILQALSEAIVRESVPAAMDNICGAVARLIVTNPDSVPLGQVLPVWLNHLPLKDDTVENDV 1003
            :.||.:|..||.....|.....:||:||||:|:::.:.:.||:.|||||.:..||||||..||..
 Frog   931 QHYPKLLSLLSSVFCSEQKRQVLDNVCGAVSRMVLAHAEGVPIEQVLPVMIRSLPLKDDLEENSA 995

  Fly  1004 IQKAFRVLYLKARPSIEAHLEQILAITIEA-SYKRQMPDVETTESAVALIKEIRANYPE 1061
            :.|....:|.:|...:.|.|:.:....... ..|...||.|  |:.:.|::.:...:|:
 Frog   996 VFKCIVFIYERAPQQVIAQLKDLTRTFAHVLGTKEIKPDTE--ETIIHLLRNMAQRFPQ 1052

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Apl	NP_730182.1	IBN_N	29..90	CDD:197981	21/60 (35%)
		KAP95	<304..703	CDD:227540	152/415 (37%)
		HEAT repeat	356..384	CDD:293787	10/27 (37%)
		HEAT repeat	397..427	CDD:293787	14/29 (48%)
		HEAT repeat	438..473	CDD:293787	10/34 (29%)
ipo4	NP_001008011.2	CRM1	3..>198	CDD:227432	55/206 (27%)
		IBN_N	23..89	CDD:197981	23/67 (34%)
		HEAT repeat	350..378	CDD:293787	10/27 (37%)
		HEAT_EZ	363..418	CDD:463906	22/54 (41%)
		HEAT repeat	388..421	CDD:293787	15/32 (47%)
		KAP95	<424..567	CDD:227540	58/152 (38%)
		HEAT repeat	432..461	CDD:293787	10/34 (29%)
		HEAT repeat	474..504	CDD:293787	10/29 (34%)
		HEAT repeat	693..737	CDD:293787	9/43 (21%)
		HEAT repeat	746..773	CDD:293787	7/26 (27%)
		HEAT repeat	853..882	CDD:293787	7/28 (25%)
		HEAT repeat	894..924	CDD:293787	8/29 (28%)
		HEAT_EZ	909..963	CDD:463906	17/53 (32%)
		HEAT repeat	933..962	CDD:293787	12/28 (43%)