Protein Alignment Apl and Karybeta3

DIOPT Version :10

• Sequence 1: NP_730182.1
• Gene: Apl / 59216
• FlyBaseID: FBgn0042178
• Length: 1080
• Species: Drosophila melanogaster
• Sequence 2: NP_524226.1
• Gene: Karybeta3 / 40581
• FlyBaseID: FBgn0087013
• Length: 1105
• Species: Drosophila melanogaster
• Alignment Length: 1193
• Identity: 250/1193 - (20%)
• Similarity: 500/1193 - (41%)
• Gaps: 232/1193 - (19%)

  Fly     2 EAAILDIINGILTIDTERIRESTAKMLKAYENPDSLLVLTQIVMSDRPVQE----RQVAAVLLKR 62
            :|....::..:|:.|.: :|:...   :||.|....|.:|.::.:.:..|:    ||:|||||:|
  Fly     5 QAHFQQLLASLLSTDND-VRQQAE---EAYNNLSRELKVTHLLGNIQNGQQSEEARQMAAVLLRR 65

  Fly    63 --RVKKLRHWQLVPAEHQAAIKSNMLQVLIAVKEKT---VKGTVAFIIGSLVRH--EEGEQNSWR 120
              ..:....::.:|||.|..:   :.|:|:||:::.   ::..:..::..:.|:  :|...|.|
  Fly    66 LFTTEFFDFYKGLPAESQNQL---LQQILLAVQQEVTPQLRRKICEVVAEVARNLIDEDCNNQW- 126

  Fly   121 EEILKFIYERCSSPDPIESERGSSIFSSLMDAAPDQFSDHTDTMFPLLAGILVTAEANGNMATPT 185
            .:||:|:::..:||.|...|....||||:.....:|.:.:.|.:..:||
  Fly   127 PDILQFLFQCANSPTPQLQESALRIFSSVPSIFGNQEAQYIDLIKQMLA---------------- 175

  Fly   186 VHNMLTGSCFLLPFVSGHSNAEQIVVKAVPLILKALAAFV---EK-------------------- 227
             .:|..||            ..::.|:||    :|:.||:   :|
  Fly   176 -KSMDAGS------------DPEVRVQAV----RAVGAFILYHDKENETAIHKHFADMLPRMIHI 223

  Fly   228 -GYSIEF---MGAFDIIDSMAEHVPHLLTGNVKLLLEFCLMIARNKQFDASIRVQVLTFVGSLVR 288
             |.:||.   .....::..|.|:.|..|...::.:.|.|:.:..::.|:.|.|..||..:.||..
  Fly   224 TGETIEAQDDQSLLKLLIEMTENCPKFLRPQLEFIFEVCMKVFSSQDFEDSWRHLVLEVMVSLAE 288

  Fly   289 LKKKIIMKQ--KLLQPTLSVLFEVICQDDLEEG--------DDDYFSSESLSSPSNAAAQ-TLDL 342
            ....:|.|:  |.:...:.::..::...|.:|.        |||:       |.:|..|: :||.
  Fly   289 NAPSMIRKRADKYIVALIPLILHMMTDLDDDENWSTADVVDDDDH-------SDNNVIAESSLDR 346

  Fly   343 MALHMVPDKFIPPLLDLLEPALQSPEPVLRRSSFICMGVIAEGCSEAIGKKYLEVMLNIIKAGVL 407
            :|..:.....:|.:::.|...|...:...|.::.:.:..|.|||     .|.:|.:|:.:.:|||
  Fly   347 LACGLGGKIVLPLVMNALPVMLGHADWKHRFAALMAISAIGEGC-----HKQMEAILDEVMSGVL 406

  Fly   408 ----DSVMFVRTAAFFALGQFS-EFLQPTICKFAPQILPVLFDYLNQLV---LELKVGEPDSKHM 464
                |....||.||..|:||.| :|.|....||..|::|.|...|:.:.   ::...|.
  Fly   407 NFLSDPHPRVRYAACNAIGQMSTDFAQTFEKKFHSQVIPGLLSLLDDVENPRVQAHAGA------ 465

  Fly   465 DRMFYALETFCENLDEDIVP-YLPTLMDRL-------FGVMEPQNSNQMREMALSAIAAVSAAAK 521
                 ||..|.|:..::|:. ||..:|.:|       |..:..:.:..:.|..::.||:|:...:
  Fly   466 -----ALVNFSEDCPKNILTRYLDGIMAKLETILNSKFKELVEKGNKLVLEQVVTTIASVADTCE 525

  Fly   522 ENLMPYFPRIMTVLQGCLVKDCPKEMYSQRIQAIDTLAALCRELGKDNIIPLADDTMNFCLMMLE 586
            ...:.|:.|:|..|:..:......::...|.:.|:.::.:...:|::..|..|.:.|:..|:...
  Fly   526 SEFVAYYDRLMPCLKFIIQNANSDDLRMLRGKTIECVSLIGLAVGREKFIGDAGEVMDMLLVNHT 590

  Fly   587 DG----PDDPE--YRRSIYNLMSSLSSVVNESMASVFPKFIDRIMESVIFSEDMVPNVSDNADDD 645
            :|    .|||:  |..:.:..|..:       :...|.:::..:|..|:.:..|.|.|:...:|:
  Fly   591 EGGELADDDPQTSYLITAWARMCKI-------LGKQFEQYLPLVMGPVMRTATMKPEVAMLDNDE 648

  Fly   646 LALVDAPDIE---IDLEHTDDEDDQDAYPVENDYIVEKEEAILSLKEFATHTGAAFAPYLQSAFE 707
            :..:|. |::   |:|      .:|..:.:....:.:|..|...|..:|......||.|.:....
  Fly   649 VEDIDG-DVDWSFINL------GEQQNFAIRTAGMDDKASACEMLVCYARELKEGFAEYAEDVVR 706

  Fly   708 NVYKMIDHPQGD-VRMACIDSICSFITALHKLDDAAGLKRACEIAIPKFAHIMRTDDQVAVVLRM 771
            .:..|:.....| ||.|..:|: .::....|:.....|:.......|:...::.|:.:..|...:
  Fly   707 QMLPMLKFYFHDGVRTAAAESL-PYLLDCAKIKGPQYLEGMWMFICPELLKVIVTEPEPDVQSEL 770

  Fly   772 LDVL-------------YDVFKYVPAINSQ---EHAELIFGCIRDIFTNKMACQFNEE--SGGGD 818
            |:.|             .|..|.|..|.::   ||.|.         .:|.....|||  ..|.:
  Fly   771 LNSLAKCIETLGPNCLNEDAMKQVLEIINKYVLEHFER---------ADKRLAARNEEDYDDGVE 826

  Fly   819 DECSEESEND-----------EMLFE-NAANLFPMFGLTLQPELFSLYFGRLYHFYIQRLAKVKE 871
            :|.:|:.:.|           ..||: |.|...|.|      |..:.:|.:|    ::....|.:
  Fly   827 EELAEQDDTDVYILSKIVDITHALFQTNKAQFLPAF------EQVAPHFVKL----LEPSRPVAD 881

  Fly   872 RDLPEQRAYIYGALADCCKALKGCCATYFDALRPIFIAGSRDSDAKARQNSYFALGEI-VFHSEE 935
            |   :....::..|.:.|..   .||.|.....|..:....|...:.||.:.:..|.: .|..|:
  Fly   882 R---QWGLCVFDDLIEFCGP---ACAPYQQIFTPALVQYVCDKAPEVRQAAAYGCGVLGQFAGEQ 940

  Fly   936 KSF---ESYPTILQALSEAIVRE-SVPAAMDNICGAVARLIVTNPDSVP-LGQVLPVWLNHLPLK 995
            .:.   :..|.::|.:::...|| ...:..:|...|.|:::..|..::. :.:::.||.:.||:.
  Fly   941 FAHTCAQIIPLLVQVINDPKAREIENISPTENAISAFAKILKYNNSALSNVDELIGVWFSWLPVS 1005

  Fly   996 DDTVEN--------DVIQKAFRVLYLKARPSIEAHLEQILAITIEASYKRQMPDVE--TTESAVA 1050
            :|:.|.        |:|:....|: |.|.   ..:|.:|::|..| |:..::.:.:  |....:.
  Fly  1006 EDSEEAAHIYGYLCDLIEGNHPVI-LGAN---NGNLPRIVSIIAE-SFCTKVVEAQSATGTRMLT 1065

  Fly  1051 LIKEIRANYPELFSK-VSNMNPE 1072
            ::|::.:| ||:.:. .|.::||
  Fly  1066 IVKQVESN-PEVMAACASTLSPE 1087

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Apl	NP_730182.1	IBN_N	29..90	CDD:197981	19/66 (29%)
		KAP95	<304..703	CDD:227540	93/432 (22%)
		HEAT repeat	356..384	CDD:293787	4/27 (15%)
		HEAT repeat	397..427	CDD:293787	13/34 (38%)
		HEAT repeat	438..473	CDD:293787	7/37 (19%)
Karybeta3	NP_524226.1	KAP95	6..>625	CDD:227540	149/689 (22%)
		HEAT repeat	129..157	CDD:293787	11/27 (41%)
		HEAT repeat	165..216	CDD:293787	13/83 (16%)
		HEAT repeat	235..261	CDD:293787	4/25 (16%)
		Importin_rep_4	268..358	CDD:408579	21/96 (22%)
		HEAT repeat	272..305	CDD:293787	9/32 (28%)
		HEAT repeat	357..385	CDD:293787	4/27 (15%)
		HEAT repeat	401..429	CDD:293787	11/27 (41%)
		HEAT repeat	442..473	CDD:293787	8/41 (20%)
		HEAT repeat	485..519	CDD:293787	5/33 (15%)
		HEAT repeat	532..565	CDD:293787	5/32 (16%)
		Importin_rep_6	766..875	CDD:465881	27/127 (21%)
		HEAT repeat	867..894	CDD:293787	5/33 (15%)
		HEAT repeat	906..936	CDD:293787	5/29 (17%)
		HEAT repeat	947..979	CDD:293787	6/31 (19%)
		Importin_rep_5	1007..1059	CDD:465877	12/56 (21%)