Protein Alignment Apl and Tnpo

DIOPT Version :10

• Sequence 1: NP_730182.1
• Gene: Apl / 59216
• FlyBaseID: FBgn0042178
• Length: 1080
• Species: Drosophila melanogaster
• Sequence 2: NP_477368.1
• Gene: Tnpo / 38721
• FlyBaseID: FBgn0024921
• Length: 893
• Species: Drosophila melanogaster
• Alignment Length: 1123
• Identity: 195/1123 - (17%)
• Similarity: 349/1123 - (31%)
• Gaps: 460/1123 - (40%)

  Fly    27 MLKAYENPDS-----------------------LLVLTQIVMSDRPVQERQVAAVLLKRRVKKLR 68
            :||..::||:                       :.|||::...|.|.  |.::.::||..::  .
  Fly    16 ILKESQSPDTATQMAVQMKLEEFNRYPDFNNYLIYVLTKLKTEDEPT--RSLSGLILKNNIR--M 76

  Fly    69 HWQLVPAEHQAAIKSNMLQVLIAVKEKTVKGTVAFIIGSLVRHEEGEQNSWREEILKFIYERCSS 133
            |...:..|....||...||. :......::.||..:|.::.  ..|..::| .::|..:.|...:
  Fly    77 HGTTLQPEIVEYIKHECLQA-VGDASPLIRATVGILITTIA--SNGGLHNW-PQLLPSLCEMLDN 137

  Fly   134 PDPIESERGSSIFSSLMDAAPDQFSDHTDTMFPLLAGILVTAEANG--NMATPTVHNMLTGSCFL 196
            .|....|   ..||:|.....|.            |.||.:|..|.  |:..|........|.
  Fly   138 QDYNVCE---GAFSALQKICEDS------------AEILDSAALNRPLNIMIPKFLEYFKHSS-- 185

  Fly   197 LPFVSGHSNA--EQIVVKAVPLILKALAAFVEKGYSIEFMGAFDIIDSMAEHVPHLLTGNVKLL- 258
             |.:..|:.|  .|.::.....::..:.:|:|..:.:    :.|....:.::|.|   |.|.||
  Fly   186 -PKIRSHAIACINQFIINRSQALMLNIDSFIENLFHL----SSDEDHEVRKNVCH---GLVMLLE 242

  Fly   259 -------------LEFCLMIARNKQFDASIRVQVLTFVGSLVRLKKKIIMKQKLLQPTLSVLFEV 310
                         :|:  |:.|.:..|..:.::...|   .:.|.::.|.|. :|.|.|:.|..|
  Fly   243 VRMDRLMPHMSQIIEY--MLLRTQDTDEGVALEASEF---WLSLAEQSICKD-VLAPYLAQLAPV 301

  Fly   311 IC------------------QDDL-----------------------EEG--------DDDYF-- 324
            :.                  :||:                       :||        |||.|
  Fly   302 LVRGMRYSEVDIILLKGNVEEDDMVPDREEDIRPRFHKSRAHTIRSTQEGGAGATGDDDDDEFED 366

  Fly   325 -----SSESLSSPSNAAAQTLDLMALHMVPDKFIPPLLDLLEPALQSPEPVLRRSSFICMGVIAE 384
                 ||.|..:....:|..||::| ::..:..:|.:|.:|:..|...|.|::.|..:.:|.|||
  Fly   367 GMDDDSSLSEWNLRKCSAAALDVLA-NVFREDCLPVVLPILKETLFHQEWVIKESGVLALGAIAE 430

  Fly   385 GCSEAIGKKYLEVMLNIIKAGVLDSVMFVRTAAFFALGQFSEFLQPTICKFAPQILPVLFDYLNQ 449
            ||.:.:.:...|::..:|.. :.|....||:...:.|.:::.::
  Fly   431 GCMQGMIQHLPELIPYLISC-LSDKKALVRSITCWTLSRYANWV--------------------- 473

  Fly   450 LVLELKVGEPDSKHMDRMFYALETFCENLDEDIVPYLPTLMDRLFGVMEPQNSNQMREMALSAIA 514
                  |.:|.                  |:.:.|.:..|:.|:.     .::.:::|.|.||.|
  Fly   474 ------VNQPH------------------DQYLKPLMEELLKRIL-----DSNKRVQEAACSAFA 509

  Fly   515 AVSAAAKENLMPYFPRIMTVLQGCLVKDCPKEMYSQRIQAIDTLAALCRELGKDNIIPLADDTMN 579
            .:...|...|:||...|:..|.....|      |..:                 |::.|.|
  Fly   510 TLEEEACTELVPYLEYILKTLVFAFSK------YQHK-----------------NLLILYD---- 547

  Fly   580 FCLMMLEDGPDDPEYRRSIYNLMSSLSSVVNESMASVFPKFIDRIMESVIFSEDMVPNVSDNADD 644
                             ::..|..|:...:|:      |::||.:|..:|...:::
  Fly   548 -----------------AVGTLADSVGHHLNK------PQYIDILMPPLIDKWNLL--------- 580

  Fly   645 DLALVDAPDIEIDLEHTDDEDDQDAYPVENDYIVEKEEAILSLKEFATHTGAAFAPYLQSAFENV 709
                              .:||:|.:|:           :..|...||...:.|.||....:...
  Fly   581 ------------------KDDDKDLFPL-----------LECLSSIATALQSGFLPYCDPVYRRC 616

  Fly   710 YKMI----------------DHPQGDVRMACIDSICSFITALHKLDDAAGLKRACEIAIPKFAHI 758
            ..:|                |||..:..:..:|.:...         |.||.|..|..:.. ::|
  Fly   617 ISLIEQTINQEMLCKQNQTYDHPDKERMIVALDLLSGL---------AEGLDRHIETLVAN-SNI 671

  Fly   759 MRTDDQVAVVLRMLDVLYDVFKYVPAINSQEHAELIFGCIRDIFTNKMACQFNEESGGGDDECSE 823
            |                                .|::.|::|:
  Fly   672 M--------------------------------HLLYQCMQDV---------------------- 682

  Fly   824 ESENDEMLFENAANLFPMFGLTLQPELFSLYFGRLYHFYIQRLAKVKERDLPEQRAYIYGALADC 888
                                                              |||.|...:..|.|.
  Fly   683 --------------------------------------------------LPEVRQSSFALLGDL 697

  Fly   889 CKALKGC-------CATYF----DALRPIFIAGSRDSDAKARQNSYFALGEIVFHSEEKSFESYP 942
            .||   |       .|.:|    ..|.|.||:        ...|:.:|:|||.....|::.:...
  Fly   698 TKA---CFPHVHPFMADFFPILGQNLNPDFIS--------VCNNATWAIGEICMKLGEETKQYIR 751

  Fly   943 TILQALSEAIVRESVP-AAMDNICGAVARLIVTNPDSVPLGQVLPV------------W---LNH 991
            .:|..|...|.|.:.| ..::|....:.|          ||.|.||            |   |.|
  Fly   752 LVLSDLFIIINRPNTPKTLLENTAITIGR----------LGYVCPVEVAPYLPEFVRQWCTSLRH 806

  Fly   992 LPLKDDTVENDVIQKAFR 1009
            :.      :||....|||
  Fly   807 IR------DNDEKDSAFR 818

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Apl	NP_730182.1	IBN_N	29..90	CDD:197981	17/83 (20%)
		KAP95	<304..703	CDD:227540	77/454 (17%)
		HEAT repeat	356..384	CDD:293787	8/27 (30%)
		HEAT repeat	397..427	CDD:293787	5/29 (17%)
		HEAT repeat	438..473	CDD:293787	2/34 (6%)
Tnpo	NP_477368.1	KAP95	22..754	CDD:227540	173/1035 (17%)
		HEAT repeat	127..155	CDD:293787	7/30 (23%)
		HEAT repeat	172..202	CDD:293787	6/32 (19%)
		HEAT repeat	213..239	CDD:293787	6/32 (19%)
		HEAT repeat	252..281	CDD:293787	5/33 (15%)
		HEAT repeat	402..430	CDD:293787	8/27 (30%)
		HEAT repeat	442..472	CDD:293787	6/30 (20%)
		HEAT repeat	481..510	CDD:293787	7/33 (21%)