Protein Alignment Apl and imb-3

DIOPT Version :10

• Sequence 1: NP_730182.1
• Gene: Apl / 59216
• FlyBaseID: FBgn0042178
• Length: 1080
• Species: Drosophila melanogaster
• Sequence 2: NP_490715.1
• Gene: imb-3 / 3565440
• WormBaseID: WBGene00002077
• Length: 1092
• Species: Caenorhabditis elegans
• Alignment Length: 1146
• Identity: 236/1146 - (20%)
• Similarity: 462/1146 - (40%)
• Gaps: 141/1146 - (12%)

  Fly     7 DIINGILTIDTERIRESTAKMLKAYENPDSLLVLTQIVMSDRPVQERQVAAVLLKRRVKKLRH-- 69
            ::|..:.:.|.: ||:...::.:..|.|..:..|.:.........:.:...::..|||  |..
 Worm     8 ELITKLQSADND-IRKQAEEVYEKIEGPTKVAALFEAYTHHTNNSDARSTVLVFLRRV--LARDW 69

  Fly    70 ---WQLVPAEHQAAIKSNMLQVLIAVKEKTVKGTVAFIIGSLVRH--EEGEQNSWREEILKFIYE 129
               |:.:..|::..|.:.:|::::...|.::|..:|.:|..:..:  ::....:| ..:|: :.:
 Worm    70 DAIWETLNEENKQRILAKVLEMIVHETELSIKKKIADLISEIASNLIDDSGDMTW-GGVLE-LMD 132

  Fly   130 RCSSPDPIESE--RGSSIFSSLMDAAPDQFSDHTDTMFPLLAGILVTAEANGNMATPTVHNMLTG 192
            .|     ::||  .|:.|...::...|..|.:......|.|..:|...     ||||.:....|.
 Worm   133 HC-----LKSEDLTGNYIALLILRGCPIIFGNRLAHFLPTLKVVLEKC-----MATPDLQIKATA 187

  Fly   193 SCFLLPFVSGHSNAEQIV---VKAVPLILKALAAFVEKGYSIEFMGAFDIIDSMAEHVPHLLTGN 254
            ...::.|...:...:.:|   ...||.:|:......::..|...:|.|   ..:|..:|..|..:
 Worm   188 VRAVIAFAVDNDEEKDVVRLMTSLVPNVLQVCNETSDEDDSDGPLGEF---AELASSLPKCLNTH 249

  Fly   255 VKLLLEFCLMIARNKQFDASIRVQVLTFVGSLVRLKKKIIMKQ------KLLQPTLSVLFEVICQ 313
            :..:|:..|.||.||:.:..:|...:..:.|.:....|.:.|.      .:|:..||.:.|:  .
 Worm   250 MSQVLQVTLAIAGNKEKNEMVRQNAIEVICSYMESAPKGLKKYAPGALGPILETLLSCMTEM--D 312

  Fly   314 DD-LEEGDDDYFSSESLSSPSNAAAQTLDLMALHMVPDKFIPPLLDLLEPALQSPEPVLRRSSFI 377
            || |.|..::....|........|...:|.:|..:.....:|..|.|:|..|.|.:..::.::..
 Worm   313 DDVLNEWLNEIEEEEDYEDIPIIAESAIDRVACCINGKVMLPVFLPLVEKLLTSEDWKMKHAALR 377

  Fly   378 CMGVIAEGCSEAIGKKYLEVMLNIIKAGVLDSVMFVRTAAFFALGQFSEFLQPTI---CKFAPQI 439
            ....:.|||..:: :.::|.::..|...|.|:...|:.||..|:||.|....||:   |..|  :
 Worm   378 AFSAVGEGCQRSM-EPHIEQIMAHITNYVNDAHPRVQYAACNAIGQMSSDFAPTLQKKCHAA--V 439

  Fly   440 LPVLFDYLNQLVLELKVGEPDSKHMDRMFYALETFCENLDEDIV-PYLPTLMDRL-------FGV 496
            :|.|.:.|::..:........|        ||..|.|...:.|: .|||.::.:|       |..
 Worm   440 IPALLESLDRTDVPRVCAHAAS--------ALVNFAEECPKSIIGQYLPFILQKLENVLSAVFNR 496

  Fly   497 MEPQNSNQMREMALSAIAAVSAAA----KENLMPYFPRIMTVLQGCLVKDCPKEMYSQRIQAIDT 557
            :..:....:.|..::|||:|:.||    ||:.....|.::.:||..      .|:...|.:.|:.
 Worm   497 LGDKRYQVVVENIVTAIASVAEAAEELFKEHHARLIPNLVHILQNV------GELKELRGKTIEC 555

  Fly   558 LAALCRELGKDNIIPLADDTMNFCLMMLEDGP-----DDPEYRRSIYNLMSSLSSVVNESMASVF 617
            ::.:...:||:.....|.:.:|    :|.||.     |||:|...| :..:...|::....|...
 Worm   556 ISLIGYAVGKEQFHATAIEILN----LLGDGMKDLAIDDPQYSYMI-SSWTRFCSILGADFAPFL 615

  Fly   618 PKFIDRIMESVIFSEDMVPNVSDNADDDLALVDAPDIEIDLEHTDDE-------DDQDAYPVEND 675
            |..:|.::.:..:..|.  |:.:|.|               .|.::|       ..:....:...
 Worm   616 PVVMDPVLRAARYRPDF--NIFNNED---------------VHENEEGVEYHGIGGEKTVGIRTS 663

  Fly   676 YIVEKEEAILSLKEFATHTGAAFAPYLQSAFENVYKMIDHPQGD-VRMACIDSICSFITALHKLD 739
            .:.||..|...|..||.....||.||:...:|...|.:|....| ||.|..:.:...:|.:.|..
 Worm   664 GLEEKATACDMLVAFAKEMKEAFMPYVVDVYELAIKNLDFGLHDGVRTASAEIMPCLLTCVEKQG 728

  Fly   740 DAAGLKRACEIAIPKFAHIMRTDDQVAVVLRMLDVLYDVFKYVPAIN-SQEHAELIFGCIRDIFT 803
            .|...:..||. :......|..:|.|.::...:..:....:.:.... ::|..:||...:.....
 Worm   729 LADKRRLWCEF-LKALTTSMEEEDDVEILASFMTTIGSCIEVMKTEGIAEEEVQLIISVLLKQLE 792

  Fly   804 N---KMACQFNEESGGGDDECSEESENDEMLFENAANLFPMFGLT--LQPELFSLYFGRLYHFYI 863
            |   :|:.:..|:.  .||:...:.|.|..:...|:.|..:..||  |..|.....|..:.:.:.
 Worm   793 NYGKRMSDRPVEDE--DDDDAEAKEELDYFMELEASCLGAISDLTHSLMKEFKGTIFEGMINVFN 855

  Fly   864 QRLAKVKERDLPEQRAYIYGALADCCKALKGCCATYFDALRPIFIAGSRDSDAKARQNSYFALG- 927
            ..:..::......:|.:....|.|..:...|...|.|..|.||......|...:.||.:.:..|
 Worm   856 CAIQLIEGSKQYFERQWGMCLLDDAIEFGVGHMPTRFPKLIPIMYKLLGDEYPEVRQAASYGFGV 920

  Fly   928 -EIVFHSEEKSFESYPTILQALSEAIVRESVPA------AMDNICGAVARLIVTNPDSVPL---- 981
             .|.:|..........:.|:.|:..|.||...|      |.:|...|.|::|    .:|||
 Worm   921 MAINYHQISDYRNEILSCLEPLAAMIQREDARATEESTVATENAISAFAKII----GNVPLPAEA 981

  Fly   982 -GQVLPVWLNHLPLKDDTVENDVIQKAFRVLYLKARPSI----EAHLEQILAITI----EASYKR 1037
             |:|:.::|:.||...||.|:..|......|:.|...::    ..:|.:|..:.:    ..::..
 Worm   982 YGKVVEMFLSWLPTYSDTEESPYIYTCLAELFDKQDAALFGPENQNLPRIFLVCLLSIANDAFND 1046

  Fly  1038 QMPDVETTESAVALIKEIRANYPELFSKVSNMNPEVFNYVQ 1078
            .....:|.:..|.::|:|.|::|: |::...::..:.:.:|
 Worm  1047 DDSGNQTKQRIVTILKQIYASFPQ-FAQQDGIDEHLTSVLQ 1086

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Apl	NP_730182.1	IBN_N	29..90	CDD:197981	11/65 (17%)
		KAP95	<304..703	CDD:227540	96/426 (23%)
		HEAT repeat	356..384	CDD:293787	5/27 (19%)
		HEAT repeat	397..427	CDD:293787	10/29 (34%)
		HEAT repeat	438..473	CDD:293787	6/34 (18%)
imb-3	NP_490715.1	KAP95	<218..>486	CDD:227540	64/283 (23%)
		HEAT repeat	249..283	CDD:293787	8/33 (24%)
		Importin_rep_4	263..354	CDD:408579	18/92 (20%)
		HEAT repeat	356..384	CDD:293787	5/27 (19%)
		HEAT repeat	396..426	CDD:293787	10/29 (34%)
		HEAT repeat	438..465	CDD:293787	7/36 (19%)
		HEAT repeat	526..559	CDD:293787	7/38 (18%)
		HEAT	895..922	CDD:460773	7/26 (27%)