Protein Alignment Apl and Ipo4

DIOPT Version :10

• Sequence 1: NP_730182.1
• Gene: Apl / 59216
• FlyBaseID: FBgn0042178
• Length: 1080
• Species: Drosophila melanogaster
• Sequence 2: NP_001099508.1
• Gene: Ipo4 / 290228
• RGDID: 1305206
• Length: 1081
• Species: Rattus norvegicus
• Alignment Length: 1091
• Identity: 316/1091 - (28%)
• Similarity: 553/1091 - (50%)
• Gaps: 83/1091 - (7%)

  Fly     1 MEAAILD-IINGILTIDTERIRESTAKMLKAYENPDSLLVLTQIVMSDRPVQERQVAAVLLKRRV 64
            ||.|.|: |:..:|..||||||.:|.::..|..:|.:|..|..::.|....|.||.||||.:||:
  Rat     1 MEPAGLEQILKELLMPDTERIRRATEQLQTALRDPAALPALCDLLASATDPQIRQFAAVLTRRRL 65

  Fly    65 KKLRHWQLVPAEHQAAIKSNMLQVLIAVKEKTVKGTVAFIIGSLVRHEEGEQNSWRE--EILKFI 127
            .  ..|:.:..|.:.::||.:|..|....|..|..::|.:..::.| :||.| .|.:  .:|:..
  Rat    66 S--NRWRRLAPEQRESLKSLVLTALQKETEHYVSVSLAQLSATIFR-KEGLQ-GWPQFMNLLQHS 126

  Fly   128 YERCSSPDPIESERGSSIFSSLMDAAPDQFSDHTDTMFPLLAGILVTAEANGNMATPTVHNMLTG 192
            .....||   |.|.|..:.|.::.:.|:.|..|...:..||      .|....::.|.|   |..
  Rat   127 THSAHSP---EKEVGLLLLSVVVSSQPEAFHAHQQELLQLL------IETLSEVSFPGV---LFY 179

  Fly   193 SCFLLPFVSGHSNAEQIVV--KAVPLILKALAAFVEKGYSIEFMGAFDIIDSMAEHVPHLLTGNV 255
            |...|..::.:...:.:.:  ..||.::.||...:... .::...|.:.:|.|.|....::|.::
  Rat   180 SLRTLTALARYLRPDDVSLARMLVPKVVTALRTLIPLD-EVKACEALEALDEMLETELPIITPHL 243

  Fly   256 KLLLEFCLMIARNKQFDASIRVQVLTFVGSLVRLKKKIIMKQKLLQPTLSVLFEVIC-------- 312
            ..:|.|||.:|:|.....:|||::|..:..||::|.|.::|.:||.|.|:.||.::.
  Rat   244 SEVLTFCLEVAKNVALGEAIRVRILCCLTFLVKVKSKALLKNRLLPPLLNALFPIMAAEPPLGQL 308

  Fly   313 -QDDLEEGDDDYFSSESLSSPSNAAAQTLDLMALHMVPDKFIPPLLDLLEPALQSPEPVLRRSSF 376
             .:|.:..|||........:|.:.|.|.:|::|||:.|:|..|.::.:||.||:|..|..|::.|
  Rat   309 DPEDQDSDDDDLEIGLMGETPKHFAVQVVDMLALHLPPEKLCPHVMPMLEEALRSEAPYQRKAGF 373

  Fly   377 ICMGVIAEGCSEAIGKKYLEVMLNIIKAGVLDSVMFVRTAAFFALGQFSEFLQPTICKFAPQILP 441
            :.:.|:::|..:.|.::.|..:|.|:..|:.|....||.||.||||||||.|||.|..::.:::|
  Rat   374 LVLAVLSDGAGDHIRQRLLYPLLQIVCKGLDDPSQVVRNAALFALGQFSENLQPHISSYSEEVMP 438

  Fly   442 VLFDYLNQLVLELKVGEPDSKHMDRMFYALETFCENLDEDIVPYLPTLMDRLFGVMEPQNSNQMR 506
            :|..||..:.:      .::.|:.:..||||.|.|||...:.||||.||:.:...::..:..:.:
  Rat   439 LLLTYLKSVPM------GNTHHLAKACYALENFVENLGPKVQPYLPELMECMLQPLKNPSKARTK 497

  Fly   507 EMALSAIAAVSAAAKENLMPYFPRIMTVLQGCLVKDCPKEMYSQRIQAIDTLAALCRELGKDNII 571
            |:|:|||.|::.||:::|:||||.:|..::..|:.. ..:::..:||:::||..|.|.|| :::.
  Rat   498 ELAVSAIGAIATAAQDSLLPYFPTVMEHIREFLLTG-HDDLHLVQIQSLETLGVLARALG-ESMK 560

  Fly   572 PLADDT----MNFCLMMLEDGPDDPEYRRSIYNLMSSLSSVVNESMASVFPKFIDRIMESVIFSE 632
            |||::.    :..|:.:     |||:.||..|:|.::||.::.||:....|:....::.|:..:|
  Rat   561 PLAEECCQLGLGLCIHV-----DDPDVRRCTYSLFAALSGLMGESLGPYLPQITTLMLLSLRSTE 620

  Fly   633 DMVPNV-----------SDNADDDLALVDAPDIEIDLEHTDDEDDQDAYPVENDYIVEKEEAILS 686
            .:||..           ...|:::..|:|.     |:|..:|:.:...|.|||.:..|||:...:
  Rat   621 GIVPQYDGISSFLLFEDDSEAEEEEELMDE-----DMEEEEDDSEISGYSVENAFFDEKEDTCTA 680

  Fly   687 LKEFATHTGAAFAPYLQSAFENVYKMIDHPQGDVRMACIDSICSFITALHKL-------DDAAGL 744
            |.|.:.:|..||.|::.:.|:.|||:::.|..:||.|..:::..|..||||.       .:.|.|
  Rat   681 LGEISMNTSVAFLPFMDAIFDEVYKLLECPHMNVRKAAYEALGQFCCALHKACQRGPSDPNNAAL 745

  Fly   745 KRACEIAIPKFAHIMRTDDQVAVVLRMLDVLYDVFKYVPAINSQEHAELIFGC--IRDIFTNKMA 807
            :.:...|||.:...::.:.:..||:.:|:.|..|.:...|:..|....|...|  ::.:...|.|
  Rat   746 QSSLARAIPSYMQAVKVERERPVVMAVLEALTGVLRTCGALTLQPPGRLSELCNVLKAVLQKKTA 810

  Fly   808 CQFNEESGGGDDECSEESENDEMLFENAANLFPMFGLTLQPELFSLYFGRLYHFYIQRLAKVKER 872
            ||..||.   |||..:::|.|.||.|:|....|:.........|:.:|..   |....|.|.|:.
  Rat   811 CQDAEED---DDEDDDQAEYDAMLLEHAGEAIPVLAAAAGGHAFAPFFAT---FLPLLLCKTKQS 869

  Fly   873 DLPEQRAYIYGALADCCKALKGCCATYFDALRPIFIAGSRDSDAKARQNSYFALGEIVFHSEEKS 937
            ....::::..|.||:..:.|....|.:...|.|:.:..:|::|.:.|.|:.|.||.:..|....:
  Rat   870 CTVAEKSFAVGTLAESIQGLGAASAQFVSRLFPVLLNNAREADPEVRSNAIFGLGVLAEHGGCPA 934

  Fly   938 FESYPTILQALSEAIVRESVPAAMDNICGAVARLIVTNPDSVPLGQVLPVWLNHLPLKDDTVEND 1002
            .:.:|.:|..|...:.||......||||||:|||::.:|......|||...|:.||||:|..|..
  Rat   935 QDHFPKLLGLLLPLLARERHDRVRDNICGALARLLMASPAGKTEPQVLATLLHALPLKEDMEEWV 999

  Fly  1003 VIQKAFRVLYLKARPSIEAHLEQILAI-TIEASYKRQMPDVETTESAVALI 1052
            .|...|..|:......:.....::|.| ::.....|..||   |::|:.|:
  Rat  1000 TIGHLFSFLHQNNPDQVVGVASELLRICSLILPDNRIPPD---TKAALLLL 1047

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Apl	NP_730182.1	IBN_N	29..90	CDD:197981	19/60 (32%)
		KAP95	<304..703	CDD:227540	130/422 (31%)
		HEAT repeat	356..384	CDD:293787	9/27 (33%)
		HEAT repeat	397..427	CDD:293787	15/29 (52%)
		HEAT repeat	438..473	CDD:293787	8/34 (24%)
Ipo4	NP_001099508.1	KAP95	1..>620	CDD:227540	194/648 (30%)
		HEAT repeat	353..381	CDD:293787	9/27 (33%)
		HEAT repeat	394..424	CDD:293787	15/29 (52%)
		HEAT repeat	435..464	CDD:293787	8/34 (24%)
		HEAT repeat	477..507	CDD:293787	9/29 (31%)
		HEAT repeat	900..928	CDD:293787	9/27 (33%)
		HEAT repeat	941..971	CDD:293787	13/29 (45%)