DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Arts and PSE1

DIOPT Version :9

Sequence 1:	NP_001261957.1	Gene:	Arts / 59215	FlyBaseID:	FBgn0042177	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	NP_014039.1	Gene:	PSE1 / 855356	SGDID:	S000004925	Length:	1089	Species:	Saccharomyces cerevisiae

Alignment Length:	1195	Identity:	241/1195 - (20%)
Similarity:	443/1195 - (37%)	Gaps:	317/1195 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 ERIRESTAKMLKAYENPDS-LLVLTQIVMSDRPVQERQV----------------------AAVL 59
            |.:..:..::::|:.:||: :..:.:..:|:..:.|..:                      :|||
Yeast     6 EEVNRTLLQIVQAFASPDNQIRSVAEKALSEEWITENNIEYLLTFLAEQAAFSQDTTVAALSAVL 70

  Fly    60 LKRRV-------------KKLRHWQLVPAEHQAAIKSNMLQVLIAVKEKTVKGTVAFIIGSLVRH 111
            .::..             |.:.|   :..|..|.|:|::|:..::.:..:::..::..|...|
Yeast    71 FRKLALKAPPSSKLMIMSKNITH---IRKEVLAQIRSSLLKGFLSERADSIRHKLSDAIAECV-- 130

  Fly   112 EEDKQNSWREEILKFIYERCSSPDPIESERGSSIFSSLMDAAPDQFSNHTDTIFPLLAGI--LVT 174
             :|...:| .|:|:.:.|...|.:|                      |..::.|.:|..:  |:|
Yeast   131 -QDDLPAW-PELLQALIESLKSGNP----------------------NFRESSFRILTTVPYLIT 171

  Fly   175 A-EANGNMATPTVHNMLAGTCVLLP-FISGHSDA-EQIMVKAV---------------------- 214
            | :.|.                :|| |.||.:|| :.:.:.||
Yeast   172 AVDINS----------------ILPIFQSGFTDASDNVKIAAVTAFVGYFKQLPKSEWSKLGILL 220

  Fly   215 PLILKALAAFAEKGNSNEFMGAFDIIDSMAEYVPHLLTGNVKLLLEFCLMIARNKQFDASIRVQV 279
            |.:|.:|..|.:.|..:.....|:.:..:.|..|.|.......:::|..|:.:||..:...|...
Yeast   221 PSLLNSLPRFLDDGKDDALASVFESLIELVELAPKLFKDMFDQIIQFTDMVIKNKDLEPPARTTA 285

  Fly   280 LTFV-----GSLVRLKKKIIMKQKLLQPTLSVLFEV-ICQDDLKE--GDDDYFSSESLNSPSNAA 336
            |..:     .:....|......|.|:..||.::.|| |..||..|  ..||....|.:.  .:.|
Yeast   286 LELLTVFSENAPQMCKSNQNYGQTLVMVTLIMMTEVSIDDDDAAEWIESDDTDDEEEVT--YDHA 348

  Fly   337 AQTLDLMALHMVPDKFIPPLLDLLEPALQSPEPVLRRSSFICMGVIAEGCSEA-IGK--KYLEVM 398
            .|.||.:||.:..:....||...|:..:.|.|...|.::.:.:...||||::. ||:  |.|:::
Yeast   349 RQALDRVALKLGGEYLAAPLFQYLQQMITSTEWRERFAAMMALSSAAEGCADVLIGEIPKILDMV 413

  Fly   399 LNIIKAGVLDSVMFVRTAAFFALGQFSEFLQPTICKFA-PQILPVLFDYLNQLVLELKVGEPDSK 462
            :.:|.    |....|:......|||.|....|.|.:.| .:|||.|...|        ..|..|:
Yeast   414 IPLIN----DPHPRVQYGCCNVLGQISTDFSPFIQRTAHDRILPALISKL--------TSECTSR 466

  Fly   463 HMDRMFYALETFCENLDEDIV-PYLPTLMDRLFGVMEPQNSNQMREMALSAIAAVSAAAKENLMP 526
            .......||..|.|...:||: |||.:|:..|. |:...|...::|.||:.||.::.|||...:.
Yeast   467 VQTHAAAALVNFSEFASKDILEPYLDSLLTNLL-VLLQSNKLYVQEQALTTIAFIAEAAKNKFIK 530

  Fly   527 YFPRIMTVLQGCL-VKDCPKEMYSQRIQAIDTLAALCRELGKDNIIPLADETMNFCLMMLEDGPD 590
            |:..:|.:|...| |.:....:...:.....||....  :||:.....:.|.::..:.:.....|
Yeast   531 YYDTLMPLLLNVLKVNNKDNSVLKGKCMECATLIGFA--VGKEKFHEHSQELISILVALQNSDID 593

  Fly   591 DPEFRRS-IYNLMSSLSSVVNESMASVFPKFIDRIMESVISSEDM-------VPNVSDNAEDDLA 647
            :.:..|| :....|.:..::.:....:.|..|..::.:..:::|:       ..|.....:.|:.
Yeast   594 EDDALRSYLEQSWSRICRILGDDFVPLLPIVIPPLLITAKATQDVGLIEEEEAANFQQYPDWDVV 658

  Fly   648 LVDAPDIEIDLEHTDDEDDQDAYLGENDYIVEKEEAILSLKEFATHTGAAFAPYLQSAFENVYKM 712
            .|....|.|   ||...||             |..|:..|:.:||.....||.|::...|.:
Yeast   659 QVQGKHIAI---HTSVLDD-------------KVSAMELLQSYATLLRGQFAVYVKEVMEEI--- 704

  Fly   713 IDHPQGDVRMACIDSICSFITALHKLD----DAAGLKRACEIAIPKFAHIM----RTDDQVAVVL 769
                                 ||..||    |  |::.|....||.....:    .|.::..|:|
Yeast   705 ---------------------ALPSLDFYLHD--GVRAAGATLIPILLSCLLAATGTQNEELVLL 746

  Fly   770 ------RMLDVLYDVFKYVPAINSQEHAELIFG-------CIRD----IFTNKMAC-------QF 810
                  :::..|  :.:.:|.|....|..|:.|       |:.:    .||..::.       :.
Yeast   747 WHKASSKLIGGL--MSEPMPEITQVYHNSLVNGIKVMGDNCLSEDQLAAFTKGVSANLTDTYERM 809

  Fly   811 NEESGGGD------DECSEESENDEMLFE-------------------NAANLFPM---FGLTLQ 847
            .:..|.||      ||  ||...||.|.:                   |..|::||   |.|..:
Yeast   810 QDRHGDGDEYNENIDE--EEDFTDEDLLDEINKSIAAVLKTTNGHYLKNLENIWPMINTFLLDNE 872

  Fly   848 PEL--FSL-YFGRLYHFYIQRLAKVKERDLP--------------EQRAYIYGALADCCKALKGC 895
            |.|  |:| ..|.|..:..::.|.:|...:|              :..:||.|..|....
Yeast   873 PILVIFALVVIGDLIQYGGEQTASMKNAFIPKVTECLISPDARIRQAASYIIGVCAQYAP----- 932

  Fly   896 CATYFDALRP--------IFIAGSR-DSDAKARQNSYFALGEIV--FHSEEKSFESY-------- 941
             :||.|...|        :...||: :.:..:.:|:..|:.:|:  ::|...:.::|
Yeast   933 -STYADVCIPTLDTLVQIVDFPGSKLEENRSSTENASAAIAKILYAYNSNIPNVDTYTANWFKTL 996

  Fly   942 PTI---------LQALSEAI--------VRESVPAAMDNICGAVARLIVTNPDSVPLGQVLPVWL 989
            |||         .|.||:.|        .:.::.|.:|::..|:....:|..:...:...:...|
Yeast   997 PTITDKEAASFNYQFLSQLIENNSPIVCAQSNISAVVDSVIQALNERSLTEREGQTVISSVKKLL 1061

  Fly   990 NHLPLKD-----DTVENDVIQKAFR 1009
            ..||..|     :....|:::|..:
Yeast  1062 GFLPSSDAMAIFNRYPADIMEKVHK 1086

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arts	NP_001261957.1	IBN_N	29..90	CDD:197981	15/96 (16%)
		HEAT repeat	356..384	CDD:293787	5/27 (19%)
		HEAT repeat	397..427	CDD:293787	7/29 (24%)
		HEAT repeat	438..473	CDD:293787	9/34 (26%)
PSE1	NP_014039.1	HEAT repeat	106..128	CDD:293787	2/21 (10%)
		HEAT repeat	140..168	CDD:293787	7/49 (14%)
		HEAT repeat	177..207	CDD:293787	9/45 (20%)
		HEAT repeat	222..248	CDD:293787	5/25 (20%)
		HEAT repeat	261..292	CDD:293787	6/30 (20%)
		Importin_rep_4	274..365	CDD:408579	24/92 (26%)
		HEAT repeat	368..396	CDD:293787	5/27 (19%)
		HEAT_EZ	<396..435	CDD:404407	12/42 (29%)
		HEAT_2	<403..475	CDD:404525	21/83 (25%)
		HEAT repeat	408..438	CDD:293787	9/33 (27%)
		HEAT repeat	450..477	CDD:293787	9/34 (26%)
		HEAT repeat	491..520	CDD:293787	10/29 (34%)
		Importin_rep_6	766..868	CDD:408599	21/103 (20%)
		Importin_rep_5	1001..1054	CDD:408587	8/52 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2171
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1555
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.760