DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Arts and KAP95

DIOPT Version :9

Sequence 1:	NP_001261957.1	Gene:	Arts / 59215	FlyBaseID:	FBgn0042177	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	NP_013451.1	Gene:	KAP95 / 851061	SGDID:	S000004339	Length:	861	Species:	Saccharomyces cerevisiae

Alignment Length:	858	Identity:	179/858 - (20%)
Similarity:	323/858 - (37%)	Gaps:	212/858 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AAILDIINGILAIDTERIRESTAKMLKAYENPDSLL----VLTQIVMSDR-PVQERQVAAVLLKR 62
            |.:|:  |.||:.| :.||.::...||...| |:.|    :.:|:::.:. .::.|.:||:.||.
Yeast     7 AQLLE--NSILSPD-QNIRLTSETQLKKLSN-DNFLQFAGLSSQVLIDENTKLEGRILAALTLKN 67

  Fly    63 R-VKK--------LRHW--QLVPAEHQAAIKSNMLQVLIAVKEKTVKGTVAFIIGSLVRHEEDKQ 116
            . |.|        .:.|  |:.| |.:..||:|.|..|::::.:........|  :.:...|...
Yeast    68 ELVSKDSVKTQQFAQRWITQVSP-EAKNQIKTNALTALVSIEPRIANAAAQLI--AAIADIELPH 129

  Fly   117 NSWREEILKFIYERCSSPDPIESERGSSIFSSLMDAAPDQFSNHTDTIFPLLAGILVTAEANGNM 181
            .:| .|::|.:.:...:..|...:|.|.:....|..:.|..|.           .||::..|
Yeast   130 GAW-PELMKIMVDNTGAEQPENVKRASLLALGYMCESADPQSQ-----------ALVSSSNN--- 179

  Fly   182 ATPTVHNMLAGTCVLLPFISGHSDAEQIMVKAVPLILKALAAFAE-----KGNSNEFMGAFDIID 241
                         :|:..:.|....|  ..|||.  |.||.|.|:     |.|...
Yeast   180 -------------ILIAIVQGAQSTE--TSKAVR--LAALNALADSLIFIKNNMER--------- 218

  Fly   242 SMAEYVPHLLTGNVKLLLEFCLMIARNKQFDASIRVQVLTFVGSLVRLKK------KIIMKQKLL 300
                      .|....|::   ::....|.: .|.||...| |.|.::..      |..|:|.|.
Yeast   219 ----------EGERNYLMQ---VVCEATQAE-DIEVQAAAF-GCLCKIMSLYYTFMKPYMEQALY 268

  Fly   301 QPTLSVL--------------FEVICQDDLKEGDDDYFSSESLNSPSNAAAQTLDLMALHMVPDK 351
            ..|::.:              :..||::::   |..|..::...||    .|:.: .||..:.|
Yeast   269 ALTIATMKSPNDKVASMTVEFWSTICEEEI---DIAYELAQFPQSP----LQSYN-FALSSIKD- 324

  Fly   352 FIPPLLDLLEPALQSPEP---VLRRSSFICMGVIAEGCSEAIGKKYLEVMLNIIKAGVLDSVMFV 413
            .:|.||:||....:.||.   .:..|:..|:.:.|:.|    |...||.:|..::..:.......
Yeast   325 VVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQNC----GNHILEPVLEFVEQNITADNWRN 385

  Fly   414 RTAAFFALGQF---SEFLQPTICKFAPQILPVLFDYLNQLVLELK------VGE-PDS------- 461
            |.||..|.|..   .:.:|.|.  :..|.||.:.:.:|...|::|      :|. .||
Yeast   386 REAAVMAFGSIMDGPDKVQRTY--YVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVAESIDP 448

  Fly   462 -KHMDRMFYA----------------------LETFCENLDEDIVPYLPTLMDRLFGVMEP-QNS 502
             :|:..:..|                      :|...|.....|..:.|.|:|.|.|.... .|.
Yeast   449 QQHLPGVVQACLIGLQDHPKVATNCSWTIINLVEQLAEATPSPIYNFYPALVDGLIGAANRIDNE 513

  Fly   503 NQMREMALSA-----------IAAVSAAAKENLMPYFPRIMTVLQGCLVKDCPKEMYSQRIQAID 556
            ...|..|.||           :|..||:....:|....:.|:|.:..|..:..:.:...:...:.
Yeast   514 FNARASAFSALTTMVEYATDTVAETSASISTFVMDKLGQTMSVDENQLTLEDAQSLQELQSNILT 578

  Fly   557 TLAALCRELGKDNIIPLADETMNFCLMMLEDGPDDPEFRRSIYNLMSSLSSVVNESMASVFPKFI 621
            .|||:.|: ...::.|:||..|.....:||. .|.......::..:|:|::    |:...|.|::
Yeast   579 VLAAVIRK-SPSSVEPVADMLMGLFFRLLEK-KDSAFIEDDVFYAISALAA----SLGKGFEKYL 637

  Fly   622 DRIMESVISSEDMVPNVSDNAEDDLALVDAPDIEIDLEHTDDEDDQ---DAYLGENDYIV----- 678
            :.....::.:.:.|        |....:.|.....|:.::.:||.:   ||.:.....::
Yeast   638 ETFSPYLLKALNQV--------DSPVSITAVGFIADISNSLEEDFRRYSDAMMNVLAQMISNPNA 694

  Fly   679 --EKEEAILSL-KEFATHTGAAFAPYLQSAF-----------EN-VYKMIDHPQGDVRMACIDSI 728
              |.:.|:||: .:.|::.||.|.|||....           || ..:.:|: |..|..|.:|:.
Yeast   695 RRELKPAVLSVFGDIASNIGADFIPYLNDIMALCVAAQNTKPENGTLEALDY-QIKVLEAVLDAY 758

  Fly   729 CSFITALHKLDDA 741
            ...:..||...:|
Yeast   759 VGIVAGLHDKPEA 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arts	NP_001261957.1	IBN_N	29..90	CDD:197981	20/76 (26%)
		HEAT repeat	356..384	CDD:293787	8/30 (27%)
		HEAT repeat	397..427	CDD:293787	6/32 (19%)
		HEAT repeat	438..473	CDD:293787	11/71 (15%)
KAP95	NP_013451.1	KAP95	1..861	CDD:227540	179/858 (21%)
		HEAT repeat	135..164	CDD:293787	5/28 (18%)
		HEAT repeat	180..215	CDD:293787	12/38 (32%)
		HEAT repeat	224..253	CDD:293787	8/33 (24%)
		HEAT repeat	264..293	CDD:293787	3/28 (11%)
		HEAT repeat	326..357	CDD:293787	9/30 (30%)
		HEAT repeat	370..398	CDD:293787	6/27 (22%)
		HEAT repeat	411..441	CDD:293787	7/29 (24%)
		HEAT repeat	454..479	CDD:293787	1/24 (4%)
		HEAT repeat	496..527	CDD:293787	10/30 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910