DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Arts and ILA

DIOPT Version :9

Sequence 1:	NP_001261957.1	Gene:	Arts / 59215	FlyBaseID:	FBgn0042177	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	NP_001185313.1	Gene:	ILA / 842787	AraportID:	AT1G64790	Length:	2696	Species:	Arabidopsis thaliana

Alignment Length:	1266	Identity:	229/1266 - (18%)
Similarity:	411/1266 - (32%)	Gaps:	436/1266 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LAIDTERIRESTAKMLKAYENPDS-------------------------LLVLTQIVMSDRPVQE 52
            ||.|..::.....|:|:....|..                         |.:|.:::.||:..:.
plant  1353 LARDDPKVHNVVEKLLEVLNTPSESVQRAVSTCLSPLVLSKQEEAPALFLRLLDKLMKSDKYGER 1417

  Fly    53 R----QVAAVLLKRRVKKLRHWQLVPAEHQAAIKSN----------------------------- 84
            |    .:|.|::...:..|:.:.|:....:|.|..|
plant  1418 RGAAFGLAGVVMGFGISSLKKYGLIVTLQEALIDRNSAKRREGALLAFECLCEKLGKLFEPYVIK 1482

  Fly    85 MLQVLI--------AVKEKTVKGT-----------VAFIIGSLVRHEEDKQNSWREEILKFIYER 130
            ||.:|:        ||:|......           |..::.||::..|||  :||.:
plant  1483 MLPLLLVSFSDQVGAVREAAECAARAMMSQLSAYGVKLVLPSLLKGLEDK--AWRTK-------- 1537

  Fly   131 CSSPDPIESERGSSIFSSLMDAAPDQFSNHTDTIFPLLAGILVT----------AEANGNMATPT 185
                     :....:..::...||.|.|.....:.|.|..:..|          .::.|.:|...
plant  1538 ---------QSSVQLLGAMAFCAPQQLSQCLPRVVPKLTEVFKTIQVLTDTHPKVQSAGQLALQQ 1593

  Fly   186 VHNMLAGTCVLLPFISGHSDAEQIMVKAVPLILKALAAFAEKGNSNE-------------FMGAF 237
            |     |:.:..|.||          ..||.:|.||.      :.||             |:.:.
plant  1594 V-----GSVIKNPEIS----------SLVPTLLLALT------DPNEYTRHALDTLLQTTFVNSV 1637

  Fly   238 DIIDSMAEYVPHL-----------------LTGNVKLLLEFCLMIARNKQFDASIRVQVLTFVGS 285
            | ..|:|..||.:                 :.||:      |.::...|        .::.::|.
plant  1638 D-APSLALLVPIVHRGLRERSSETKKKASQIVGNM------CSLVTEPK--------DMIPYIGL 1687

  Fly   286 LVRLKKKIIMKQKLLQPTLSVLFEVICQDDLKEGDDDY----------FSSESLNSPSNAAAQTL 340
            |:...||:::..  :....||....:.......|:|::          ..|::.|.....|||.|
plant  1688 LLPEVKKVLVDP--IPEVRSVAARAVGSLIRGMGEDNFPDLVPWLFETLKSDTSNVERYGAAQGL 1750

  Fly   341 DLMALHMVPDKFIPPLLDLLEPALQSPEPVLRRSSFICMGVIAEGCSEAIGKKYLEVMLNIIKAG 405
            ..:...:..|.|...|.||:.........|  |..::.:.........|..:|||:::|..|..|
plant  1751 SEVIAALGTDYFENILPDLIRHCSHQKASV--RDGYLTLFKFLPRSLGAQFQKYLQLVLPAILDG 1813

  Fly   406 VLDSVMFVRTAAFFALGQFSEFLQPTICKFAPQILPVLFD-------YLNQLVLEL------KVG 457
            :.|....||.|   |||.....::.......|.:||.:.|       .:.|..:||      ||.
plant  1814 LADENESVRDA---ALGAGHVLVEHHATTSLPLLLPAVEDGIFNDNWRIRQSSVELLGDLLFKVA 1875

  Fly   458 EPDSKHMDRMFYALETFCENLDEDIVPYLPTLMDRLFGVMEPQN-------------SNQMREMA 509
            ....|.:      ||...::...........::| :.| |:.:|             |..:|:.|
plant  1876 GTSGKAL------LEGGSDDEGASTEAQGRAIID-ILG-MDKRNEVLAALYMVRTDVSLSVRQAA 1932

  Fly   510 LSAIAAVSAAAKENLMPYFPRIMTVLQGCLVKDCPKEMYSQRIQAIDTLAALCRELGKDNIIPLA 574
            |.....:.|...:.|    ..||.:|...|:.........:|..|..:|..|.|:|| :.::||
plant  1933 LHVWKTIVANTPKTL----KEIMPILMSTLISSLASPSSERRQVAGRSLGELVRKLG-ERVLPL- 1991

  Fly   575 DETMNFCLMMLEDGPDDPEFRRSIYNLMSSLSSVVNESMASV----FPKFIDRIMESV------- 628
                  .:.:|..|..||:..:     ...:...:||.|||.    ...|:|:::.::
plant  1992 ------IIPILSKGLKDPDVDK-----RQGVCIGLNEVMASAGRSQLLSFMDQLIPTIRTALCDS 2045

  Fly   629 ---------ISSEDMVPNVSDNAEDDL--ALVDAPDIEIDLEHTDDEDDQDAYLGENDYIVEKEE 682
                     ::...:..:....|.|::  .|::|      ||  |||....|..|....|..:..
plant  2046 ALEVRESAGLAFSTLYKSAGLQAMDEIIPTLLEA------LE--DDEMSTTALDGLKQIISVRTA 2102

  Fly   683 AIL---------------------SLKE-----FATHTGAAFAPYL--------------QSAFE 707
            |:|                     :|.|     |.||.|......|              |.|.|
plant  2103 AVLPHILPKLVHLPLSALNAHALGALAEVAGAGFNTHLGTILPALLSAMGGENKEVQELAQEAAE 2167

  Fly   708 NVYKMIDHPQGDVRMACIDSICSFITALHK--LDDAAGLKRACEIAIPKF---AHIMRTDDQVAV 767
            .|..:||.          :.:.:.::.|.|  .|..|.::|:....|..|   :.:...|:...:
plant  2168 RVVLVIDE----------EGVETLLSELLKGVSDSQASIRRSSAYLIGYFFKSSKLYLIDEAPNM 2222

  Fly   768 VLRMLDVLYDVFKYVPAINSQEHAELIFGCIRDIFTNKMACQFNEESGGGDDECSEESENDEMLF 832
            :..::.:|.|......|::.:..|.:|....:::..:.:                       .|.
plant  2223 ISTLIVMLSDSDSTTVAVSWEALARVIGSVPKEVLPSYI-----------------------KLV 2264

  Fly   833 ENAANLFPMFGLTLQPELFSLYFGRLYHFYIQRLAKVKERDLPEQRAYIYGALADCC--KALKGC 895
            .:|.:                            .|:.|||   .:|...|..:...|  |:||
plant  2265 RDAVS----------------------------TARDKER---RKRKGGYVVIPGLCLPKSLK-- 2296

  Fly   896 CATYFDALRPIFIAGSRDSDAKARQNSYFALGEIVFHSEEKSFESYPTILQALSEAIVRESVPAA 960
                  .|.|:|:.|.....|:.|:.:...|||::..:.|          |||.|.::
plant  2297 ------PLLPVFLQGLISGSAELREQAAIGLGELIEVTSE----------QALKEFVI------- 2338

  Fly   961 MDNICGAVARLIVTNPDSVPLGQVLPVWLNHLPLKDDTVENDVIQKAFRVLYLKARPSIEAHLEQ 1025
              .|.|.:.|:|         |...| |         .|::.::.... :|..:...:::..|.|
plant  2339 --PITGPLIRII---------GDRFP-W---------QVKSAILATLI-ILIQRGGMALKPFLPQ 2381

  Fly  1026 ILAITIEASYKKQMPDVETT---ESAVALIK 1053
                 ::.::.|.:.|...|   .:||||.|
plant  2382 -----LQTTFVKCLQDSTRTIRSSAAVALGK 2407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arts	NP_001261957.1	IBN_N	29..90	CDD:197981	15/118 (13%)
		HEAT repeat	356..384	CDD:293787	5/27 (19%)
		HEAT repeat	397..427	CDD:293787	10/29 (34%)
		HEAT repeat	438..473	CDD:293787	10/47 (21%)
ILA	NP_001185313.1	DUF3554	463..808	CDD:288893
		HEAT repeat	1364..1389	CDD:293787	3/24 (13%)
		HEAT repeat	1401..1430	CDD:293787	7/28 (25%)
		HEAT repeat	1440..1471	CDD:293787	4/30 (13%)
		HEAT repeat	1484..1509	CDD:293787	5/24 (21%)
		HEAT repeat	1521..1549	CDD:293787	7/46 (15%)
		HEAT repeat	1561..1597	CDD:293787	7/40 (18%)
		HEAT repeat	1605..1630	CDD:293787	7/30 (23%)
		HEAT repeat	1642..1671	CDD:293787	4/28 (14%)
		HEAT repeat	1689..1713	CDD:293787	4/25 (16%)
		HEAT repeat	1726..1755	CDD:293787	6/28 (21%)
		HEAT repeat	1764..1796	CDD:293787	5/33 (15%)
		HEAT repeat	1805..1831	CDD:293787	10/28 (36%)
		HEAT repeat	1841..1870	CDD:293787	7/28 (25%)
		HEAT repeat	1900..1950	CDD:293787	10/55 (18%)
		HSH155	<1947..2612	CDD:227508	110/602 (18%)
		HEAT repeat	1951..1979	CDD:293787	6/27 (22%)
		HEAT repeat	1992..2020	CDD:293787	6/32 (19%)
		HEAT repeat	2033..2063	CDD:293787	0/29 (0%)
		HEAT repeat	2071..2095	CDD:293787	9/31 (29%)
		HEAT repeat	2105..2131	CDD:293787	2/25 (8%)
		HEAT repeat	2142..2167	CDD:293787	3/24 (13%)
		HEAT repeat	2178..2205	CDD:293787	5/26 (19%)
		HEAT repeat	2223..2251	CDD:293787	5/27 (19%)
		HEAT repeat	2263..2287	CDD:293787	8/54 (15%)
		HEAT repeat	2298..2326	CDD:293787	9/27 (33%)
		HEAT repeat	2336..2370	CDD:293787	9/62 (15%)
		HEAT_EZ	2354..2408	CDD:290247	13/69 (19%)
		HEAT repeat	2381..2407	CDD:293787	8/30 (27%)
		HEAT repeat	2455..2487	CDD:293787
		HEAT repeat	2502..2523	CDD:293787
		ARM	2539..2648	CDD:237987
		HEAT repeat	2541..2574	CDD:293787
		HEAT repeat	2584..2614	CDD:293787
		HEAT repeat	2625..2651	CDD:293787
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910