DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Arts and Ipo5

DIOPT Version :9

Sequence 1:	NP_001261957.1	Gene:	Arts / 59215	FlyBaseID:	FBgn0042177	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	NP_076068.1	Gene:	Ipo5 / 70572	MGIID:	1917822	Length:	1097	Species:	Mus musculus

Alignment Length:	1136	Identity:	240/1136 - (21%)
Similarity:	484/1136 - (42%)	Gaps:	157/1136 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 KAYEN---PDSLLVLTQIVMSDRPVQE-RQVAAVLLKRRVKKL--RHWQLVPAEHQAAIKSNMLQ 87
            :.|||   ...:..|.|.:.:....:| ||:|||||:|.:...  ..:..:|::.|.||||.:|.
Mouse    31 ETYENIPGRSKITFLLQAIRNTTAAEEARQMAAVLLRRLLSSAFDEVYPALPSDVQTAIKSELLM 95

  Fly    88 VLIAVKEKTVKGTVAFIIGSLVRH--EEDKQNSWREEILKFIYERCSSPDPIESERGSSIFSSLM 150
            ::....:.:::..:..|...|.|:  :||..|.|.|. |||:::..||.:....|....||.:..
Mouse    96 IIQMETQSSMRKKICDIAAELARNLIDEDGNNQWPEG-LKFLFDSVSSQNMGLREAALHIFWNFP 159

  Fly   151 DAAPDQFSNHTDTIFPLLAGILVTAEANGNMATPTVHNMLAGTCVLLPFISGHSDA-EQIMVKAV 214
            ....:|..::.|.|..:|...:...|      .|::..:.|.........:.|:.| .:.....:
Mouse   160 GIFGNQQQHYLDVIKRMLVQCMQDQE------HPSIRTLSARATAAFILANEHNVALFKHFADLL 218

  Fly   215 PLILKALAAFAEKGNSNEFMGAFDIIDSMAEYV-PHLLTGNVKLLLEFC----LMIARNKQFDAS 274
            |..|:|:.....:.:.:......:|.|::.:|: || |...::|.|:.|    |   .|.|...:
Mouse   219 PGFLQAVNDSCYQNDDSVLKSLVEIADTVPKYLRPH-LEATLQLSLKLCGDTNL---NNMQRQLA 279

  Fly   275 IRVQVLTFVGSLVRLKKKIIMKQKLLQPTLSVLFEVICQDDLKEGDDDYFSSESLNS---PSNAA 336
            :.|.|.....:...|:|...:..:.:...|:::.      ||:| |:|:.:::.|..   .|||.
Mouse   280 LEVIVTLSETAAAMLRKHTSLIAQTIPQMLAMMV------DLEE-DEDWANADELEDDDFDSNAV 337

  Fly   337 A--QTLDLMALHMVPDKFIPPLLDLLEPALQSPEPVLRRSSFICMGVIAEGCSEAIGKKYLEVML 399
            |  ..||.||..:.....:|.:.:.:...||:|:...|.:..:.:..|.|||.:.: :..|..::
Mouse   338 AGESALDRMACGLGGKLVLPMIKEHIMQMLQNPDWKYRHAGLMALSAIGEGCHQQM-EGILNEIV 401

  Fly   400 NIIKAGVLDSVMFVRTAAFFALGQFSEFLQPTICKFAPQILPVLFDYLNQLVLELKVGEPDSKHM 464
            |.:...:.|....||.||..|:||.:       ..|||.......:.:...:|:....:.:.:..
Mouse   402 NFVLLFLQDPHPRVRYAACNAVGQMA-------TDFAPGFQKKFHEKVIAALLQTMEDQGNQRVQ 459

  Fly   465 DRMFYALETFCENLDED-IVPYLPTLMDRLFGVME-------PQNSNQMREMALSAIAAVSAAAK 521
            .....||..|.|:..:. ::|||..|:..|..:|.       .:.:..:.|..:::||:|:..|:
Mouse   460 AHAAAALINFTEDCPKSLLIPYLDNLVKHLHSIMVLKLQELIQKGTKLVLEQVVTSIASVADTAE 524

  Fly   522 ENLMPYFPRIMTVLQGCLVKDCPKEMYSQRIQAIDTLAALCRELGKDNIIPLADETMNFCLMM-- 584
            |..:||:...|..|:..:.....||:...|.:.|:.::.:...:||:..:..|.:.|...|..
Mouse   525 EKFVPYYDLFMPSLKHIVENAVQKELRLLRGKTIECISLIGLAVGKEKFMQDASDVMQLLLKTQT 589

  Fly   585 ----LEDGPDDPEFRRSIYNLMSSLSSVVNESMASVFPKFIDRIMESVISSEDMVPNVSDNAEDD 645
                :||  |||:.     :.|.|..:.:.:.:...|.:::..:|..::.:..:.|.|
Mouse   590 DFNDMED--DDPQI-----SYMISAWARMCKILGKEFQQYLPVVMGPLMKTASIKPEV------- 640

  Fly   646 LALVDAPDIEIDLEHTDDED--------DQDAYLGENDYIVEKEEAILSLKEFATHTGAAFAPYL 702
             ||:|..    |:|:..|:|        ||.::..:...:.||..|...|..:|......|..|.
Mouse   641 -ALLDTQ----DMENMSDDDGWEFVNLGDQQSFGIKTAGLEEKSTACQMLVCYAKELKEGFVEYT 700

  Fly   703 QSAFENVYKMIDHPQGD-VRMACIDSI-----CS------FITAL-HKLDDAAGLKRACEIAIPK 754
            :...:.:..::.....| ||:|..:|:     |:      ::|.: |.:.||.......|.....
Mouse   701 EQVVKLMVPLLKFYFHDGVRVAAAESMPLLLECARVRGPEYLTQMWHFMCDALIKAIGTEPDSDV 765

  Fly   755 FAHIMRTDDQVAVVLRMLDVLYDVFKYVPAINSQEHAELIFGCIR----DIFTNKMACQFNEESG 815
            .:.||.:      ..:.::|:.|     ..:|: ||.|.:.|.::    :.|.|:...|...:..
Mouse   766 LSEIMHS------FAKCIEVMGD-----GCLNN-EHFEELGGILKAKLEEHFKNQELRQVKRQDE 818

  Fly   816 GGDDECSE----ESENDEMLFENAANLFPMFGLTLQPELFSLYFGRLYHFYIQRLAKV-----KE 871
            ..|::..|    |.:||..:....:::.        ..:||.|..::..::.|.|..:     .:
Mouse   819 DYDEQVEESLQDEDDNDVYILTKVSDIL--------HSIFSSYKEKVLPWFEQLLPLIVNLICPQ 875

  Fly   872 RDLPEQR--AYIYGALADCCKALKGCCATYFDALRPIFIAGSRDSDAKARQNSYFALGEIV-FHS 933
            |..|:::  ..|:..:.:.|.......|.||.:....::.   |:..:.||.:.:.||.:. |..
Mouse   876 RPWPDRQWGLCIFDDIVEHCSPASFKYAEYFISPMLQYVC---DNSPEVRQAAAYGLGVMAQFGG 937

  Fly   934 EE-KSF--ESYPTILQALS--EAIVRESVPAAMDNICGAVARLIVTNPDSVPLGQVLPVWLNHLP 993
            :. :.|  ::.|.:::.:.  ||..:|:|.|. :|...||.:::...||.|.:.:|||.||:.||
Mouse   938 DNYRPFCTDALPLLVRVIQAPEAKTKENVNAT-ENCISAVGKIMKFKPDCVNVEEVLPHWLSWLP 1001

  Fly   994 LKDDTVEN--------DVIQKAFRVLYLKARPSIEAHLEQILAITIEASYKKQMPDVETTESAVA 1050
            |.:|..|.        |:|:....::   ..|: ..:|.:|.:|..|....:.:...:.....:|
Mouse  1002 LHEDKEEAVQTFSYLCDLIESNHPIV---LGPN-NTNLPKIFSIIAEGEMHEAIKHEDPCAKRLA 1062

  Fly  1051 -LIKEIRANYPELFSKVSNMNPEVFNYVQAL 1080
             ::::::.:.......::.::||....:|.|
Mouse  1063 NVVRQVQTSGGLWTECIAQLSPEQQAAIQEL 1093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arts	NP_001261957.1	IBN_N	29..90	CDD:197981	21/66 (32%)
		HEAT repeat	356..384	CDD:293787	5/27 (19%)
		HEAT repeat	397..427	CDD:293787	9/29 (31%)
		HEAT repeat	438..473	CDD:293787	3/34 (9%)
Ipo5	NP_076068.1	HEAT 1. /evidence=ECO:0000250\|UniProtKB:P32337, ECO:0000305\|PubMed:23541588	5..38		3/6 (50%)
		KAP95	13..>634	CDD:227540	141/635 (22%)
		HEAT 2. /evidence=ECO:0000250\|UniProtKB:P32337, ECO:0000305\|PubMed:23541588	43..77		11/33 (33%)
		HEAT 3. /evidence=ECO:0000250\|UniProtKB:P32337, ECO:0000305\|PubMed:23541588	95..122		3/26 (12%)
		HEAT 4. /evidence=ECO:0000250\|UniProtKB:P32337, ECO:0000305\|PubMed:23541588	130..157		9/27 (33%)
		HEAT 5. /evidence=ECO:0000250\|UniProtKB:P32337, ECO:0000305\|PubMed:23541588	167..201		6/39 (15%)
		HEAT repeat	177..199	CDD:293787	4/27 (15%)
		HEAT 6. /evidence=ECO:0000250\|UniProtKB:P32337, ECO:0000305\|PubMed:23541588	210..246		4/35 (11%)
		HEAT repeat	217..245	CDD:293787	4/27 (15%)
		HEAT 7. /evidence=ECO:0000250\|UniProtKB:P32337, ECO:0000305\|PubMed:23541588	254..289		10/38 (26%)
		HEAT repeat	257..289	CDD:293787	8/34 (24%)
		Importin_rep_4	268..357	CDD:408579	22/98 (22%)
		HEAT 8. /evidence=ECO:0000250\|UniProtKB:P32337, ECO:0000305\|PubMed:23541588	298..350		15/58 (26%)
		Ran-GTP binding. /evidence=ECO:0000250	325..375		13/49 (27%)
		HEAT 9. /evidence=ECO:0000250\|UniProtKB:P32337, ECO:0000305\|PubMed:23541588	352..386		5/33 (15%)
		HEAT repeat	355..387	CDD:293787	6/31 (19%)
		HEAT 10. /evidence=ECO:0000250\|UniProtKB:P32337, ECO:0000305\|PubMed:23541588	390..430		10/47 (21%)
		HEAT repeat	399..429	CDD:293787	9/36 (25%)
		HEAT 11. /evidence=ECO:0000250\|UniProtKB:P32337, ECO:0000305\|PubMed:23541588	432..472		5/39 (13%)
		HEAT repeat	441..468	CDD:293787	3/26 (12%)
		HEAT 12. /evidence=ECO:0000250\|UniProtKB:P32337, ECO:0000305\|PubMed:23541588	475..523		10/47 (21%)
		HEAT repeat	482..519	CDD:293787	7/36 (19%)
		HEAT 13. /evidence=ECO:0000250\|UniProtKB:P32337, ECO:0000305\|PubMed:23541588	525..568		9/42 (21%)
		HEAT repeat	531..564	CDD:293787	6/32 (19%)
		HEAT 14. /evidence=ECO:0000250\|UniProtKB:P32337, ECO:0000305\|PubMed:23541588	570..615		11/51 (22%)
		HEAT 15. /evidence=ECO:0000250\|UniProtKB:P32337, ECO:0000305\|PubMed:23541588	617..692		18/86 (21%)
		HEAT 16. /evidence=ECO:0000250\|UniProtKB:P32337, ECO:0000305\|PubMed:23541588	695..737		8/41 (20%)
		HEAT 17. /evidence=ECO:0000250\|UniProtKB:P32337, ECO:0000305\|PubMed:23541588	741..780		7/44 (16%)
		Importin_rep_6	765..874	CDD:408599	22/128 (17%)
		HEAT 18. /evidence=ECO:0000250\|UniProtKB:P32337, ECO:0000305\|PubMed:23541588	787..853		14/74 (19%)
		HEAT 19. /evidence=ECO:0000250\|UniProtKB:P32337, ECO:0000305\|PubMed:23541588	856..895		5/38 (13%)
		HEAT repeat	865..890	CDD:293787	4/24 (17%)
		HEAT 20. /evidence=ECO:0000250\|UniProtKB:P32337, ECO:0000305\|PubMed:23541588	903..935		8/34 (24%)
		HEAT repeat	906..934	CDD:293787	6/30 (20%)
		HEAT_EZ	921..966	CDD:404407	10/44 (23%)
		HEAT 21. /evidence=ECO:0000250\|UniProtKB:P32337, ECO:0000305\|PubMed:23541588	943..983		10/40 (25%)
		HEAT repeat	946..982	CDD:293787	9/36 (25%)
		HEAT 22. /evidence=ECO:0000250\|UniProtKB:P32337, ECO:0000305\|PubMed:23541588	990..1021		11/30 (37%)
		HEAT repeat	991..1015	CDD:293787	10/23 (43%)
		Importin_rep_5	1005..1051	CDD:408587	9/49 (18%)
		HEAT 23. /evidence=ECO:0000250\|UniProtKB:P32337, ECO:0000305\|PubMed:23541588	1032..1067		5/34 (15%)
		HEAT 24. /evidence=ECO:0000250\|UniProtKB:P32337, ECO:0000305\|PubMed:23541588	1070..1093		3/22 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2171
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1555
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.760