DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Arts and kpnb3

DIOPT Version :9

Sequence 1:	NP_001261957.1	Gene:	Arts / 59215	FlyBaseID:	FBgn0042177	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	XP_009303669.1	Gene:	kpnb3 / 569455	ZFINID:	ZDB-GENE-030424-2	Length:	1093	Species:	Danio rerio

Alignment Length:	1082	Identity:	230/1082 - (21%)
Similarity:	446/1082 - (41%)	Gaps:	176/1082 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IINGILAIDTERIRESTAKMLKAYENPDSLLVLTQIVMSDRPVQE-RQVAAVLLKRRVKKLRHWQ 71
            :::.:::.| ..:|:.:.:..........:..|.|.:......:| :|:||||| ||:......:
Zfish    10 LLSNLMSPD-NTVRKQSEEAYDTIPGQTKITFLLQAIRDASAAEEVKQMAAVLL-RRLLSSSFEE 72

  Fly    72 LVP---AEHQAAIKSNMLQVLIAVKEKTVKGTVAFIIGSLVRH--EEDKQNSWREEILKFIYERC 131
            :.|   .:.|.|||:.:|..:.:.....::.....|...|.|:  ::|..|.| .|||||:::..
Zfish    73 VYPNLTVDIQTAIKTELLAGIRSEASTNIRKKTCDIAAELARNLIDDDGNNQW-PEILKFLFDSV 136

  Fly   132 SSPDPIESERGSSIFSSLMDAAPDQFSNHTDTIFPLLAGILVTAEANGNMATPTVHNMLA----- 191
            :|.|....|....||.:.    |..|.|.......::..:||  :...:...|.:..:.|
Zfish   137 NSQDVGLREAALHIFWNF----PGIFGNQQQHYMEVIKRMLV--QCMQDQENPQIRTLSARAAAS 195

  Fly   192 ------GTCVLLPFISGHSDAEQIMVKAVPLILKALAAFAEKGNSNEFMGAFDIIDSMAEYVPHL 250
                  |...||...|          ..:|.||:|:.....:|:.:......:|.|:..:|:...
Zfish   196 FILSNEGNTALLKHFS----------DLLPGILQAVNESCYRGDDSVLKSLVEIADTAPKYLRPN 250

  Fly   251 LTGNVKLLLEFCL---MIARNKQFDASIRVQVLTFVGSLVRLKKKIIMKQKLLQPTLSVLFEVIC 312
            |...::|.|:.|.   :....:|....:.|.:.....:::|....|:.:......|:.|
Zfish   251 LEATLQLSLKLCADTNLTNMQRQLALEVIVTLSETAAAMLRKHTNIVAQSVPQMLTMMV------ 309

  Fly   313 QDDLKEGDD----DYFSSESLNSPSNAAAQTLDLMALHMVPDKFIPPLLDLLEPALQSPEPVLRR 373
              ||:|.::    |....:..:|.:.|....||.:|..:.....:|.:...:...||:|:...|.
Zfish   310 --DLEEDEEWAMADELEDDDFDSNAVAGESALDRIACGLGGKIILPMIKQHIMQMLQNPDWKYRH 372

  Fly   374 SSFICMGVIAEGCSEAIGKKYLEVMLNIIKAGVL----DSVMFVRTAAFFALGQFSEFLQPTI-C 433
            :..:.:..|.|||.:     .:|.:|:.|.:.||    |....||.||..|:||.:....||. .
Zfish   373 AGLMALSAIGEGCHQ-----QMEAILSEIVSFVLLFCQDPHPRVRYAACNAIGQMATDFAPTFQK 432

  Fly   434 KFAPQILPVLFDYLNQLVLELKVGEPDSKHMDRMFYALETFCENLDED-IVPYLPTLMDRLFGVM 497
            ||..:::..|        |:....:.:.:.......||..|.|:..:. :||||.:|:..|..:|
Zfish   433 KFHDKVISAL--------LQTMEDQSNPRVQAHAAAALINFTEDCPKTLLVPYLDSLVQHLHVIM 489

  Fly   498 E-------PQNSNQMREMALSAIAAVSAAAKENLMPYFPRIMTVLQGCLVKDCPKEMYSQRIQAI 555
            .       .:.:..:.|..:::||:|:..|:|..:||:...|..|:..:.....||:...|.:.|
Zfish   490 VAKLQELIQKGTKLVLEQVVTSIASVADTAEEKFVPYYDLFMPSLKHIVENAIQKELRLLRGKTI 554

  Fly   556 DTLAALCRELGKDNIIPLADETMNFCLMM------LEDGPDDPEFRRSIYNLMSSLSSVVNESMA 614
            :.::.:...:||:..:|.|...|...|..      |||  |||:.     :.|.|..:.:.:.:.
Zfish   555 ECISLIGLAVGKEKFMPDASAVMQLLLKTQTDFNDLED--DDPQI-----SYMISAWARMCKILG 612

  Fly   615 SVFPKFIDRIMESVISSEDMVPNVSDNAEDDLALVDAPDIEIDLEHTDDED--------DQDAYL 671
            ..|.:::..:|..::.:..:.|.|        ||:|..    |:|:..::|        ||.::.
Zfish   613 KEFQQYLPVVMGPLMKTASIKPEV--------ALLDTQ----DMENMSEDDGWEFVNLGDQQSFG 665

  Fly   672 GENDYIVEKEEAILSLKEFATHTGAAFAPYLQSAFENVYKMIDHPQGD-VRMACIDSI-----CS 730
            .:...:.||..|...|..:|......|..|.:...:.:..::.....| ||:|..:|:     |:
Zfish   666 IKTAGLEEKATACQMLVCYAKELKEGFVEYTEQVVKLMVPLLKFYFHDGVRVAAAESMPLLLECA 730

  Fly   731 ------FITAL-HKLDDAAGLKRACEIAIPKFAHIMRTDDQVAVVLRMLDVLYDVFKYVPAIN-- 786
                  ::|.: |.:.||  |.:|           :.|:....|   :.::::...|.:..:.
Zfish   731 RVRGPEYLTQMWHFMCDA--LIKA-----------IGTEPDSDV---LSEIMHSFAKCIELMGDG 779

  Fly   787 --SQEHAELIFGCIR----DIFTNKMACQFNEESGGGDDECSE----ESENDEMLFENAANLFPM 841
              :.||.|.:.|.::    :.|.|:...|...:....|::..|    |.|||..:....:::.
Zfish   780 CLNNEHFEELGGILKAKLEEHFKNQEVRQAKRQDEDYDEQVEETLQDEDENDVYILTKVSDIL-- 842

  Fly   842 FGLTLQPELFSLYFGRLYHFYIQRLAKVKERDLPEQ----RAY---IYGALADCCKALKGCCATY 899
                  ..:||.|..::..::.|.|..:.....|.:    |.:   |:..:.:.|.......|.|
Zfish   843 ------HSIFSSYREKVLPWFEQLLQLIVNLICPHRPWADRQWGLCIFDDVVEHCSPSSFKYAEY 901

  Fly   900 FDALRPIFIAGSRDSDAKARQNSYFALGEIVFHSEEK---SF-ESYPTILQALSEAIVR--ESVP 958
            |  |||: :....|:..:.||.:.:.:|.:.....|.   :| |:.|.::..:..|..|  |:|.
Zfish   902 F--LRPM-MQSLCDTSPEVRQAAAYGVGVMAQFGGENYRPAFTEAVPLLVGVIQSADSRAKENVN 963

  Fly   959 AAMDNICGAVARLIVTNPDSVPLGQVLPVWLNHLPLKDDTVE 1000
            |. :|...|||:::...|:.|.:.::||.||:.|||.:|..|
Zfish   964 AT-ENCISAVAKVMKYRPECVNVTEILPHWLSWLPLNEDKEE 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arts	NP_001261957.1	IBN_N	29..90	CDD:197981	17/64 (27%)
		HEAT repeat	356..384	CDD:293787	5/27 (19%)
		HEAT repeat	397..427	CDD:293787	12/33 (36%)
		HEAT repeat	438..473	CDD:293787	4/34 (12%)
kpnb3	XP_009303669.1	HEAT repeat	89..111	CDD:293787	2/21 (10%)
		HEAT repeat	128..156	CDD:293787	9/31 (29%)
		HEAT repeat	168..199	CDD:293787	4/32 (13%)
		HEAT repeat	212..238	CDD:293787	5/25 (20%)
		HEAT repeat	251..282	CDD:293787	6/30 (20%)
		HEAT repeat	319..341	CDD:293787	4/21 (19%)
		HEAT_2	355..463	CDD:290374	28/120 (23%)
		HEAT repeat	355..383	CDD:293787	5/27 (19%)
		HEAT_EZ	368..422	CDD:290247	17/58 (29%)
		HEAT repeat	395..425	CDD:293787	11/29 (38%)
		HEAT_EZ	409..465	CDD:290247	15/63 (24%)
		HEAT repeat	437..464	CDD:293787	4/34 (12%)
		HEAT repeat	478..515	CDD:293787	7/36 (19%)
		HEAT repeat	527..560	CDD:293787	6/32 (19%)
		HEAT_EZ	915..962	CDD:290247	10/46 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2171
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810