DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Arts and tnpo1

DIOPT Version :9

Sequence 1:	NP_001261957.1	Gene:	Arts / 59215	FlyBaseID:	FBgn0042177	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	XP_021327307.1	Gene:	tnpo1 / 562607	ZFINID:	ZDB-GENE-080819-1	Length:	891	Species:	Danio rerio

Alignment Length:	938	Identity:	186/938 - (19%)
Similarity:	334/938 - (35%)	Gaps:	285/938 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ILDIINGILAIDTERIRESTAKMLKAYENPD----SLLVLTQIVMSDRPVQERQVAAVLLKRRVK 65
            ||.::....:.||...|....|:.:..:.||    .:.|||::...|.|.  |.::.::||..||
Zfish    15 ILQLLKESQSPDTSTQRSVQQKLEQLNQYPDFNNYLIFVLTKLKTEDEPT--RSLSGLILKNNVK 77

  Fly    66 KLRHWQLVPAEHQAAIKSNMLQVLIAVKEKTVKGTVAFIIGSLVRHEEDKQNSWREEILKFIYER 130
              .|:|..|......||:..|| .|......::.||..:| :.:..:.:.|| |.|.:.|.
Zfish    78 --AHYQNFPNGVSDFIKNECLQ-SIGDSSPLIRATVGILI-TTIASKGELQN-WPELLPKL---- 133

  Fly   131 CSSPDPIESERGSSIFSSLMDAAPD----------------------QFSNHTDTIFPLLAG--- 170
            |...|..:.......|.:|.....|                      ||..|:.   |.:..
Zfish   134 CLLLDSEDYNTCEGAFGALQKICEDSAEILDSDMLERPLNVMIPKFLQFFKHSS---PKIRSHAI 195

  Fly   171 ------ILVTAEANGNMATPTVHNMLAGTCVLLPFISGHSDAE--QIMVKAVPLILKALAAFAEK 227
                  |:...:|......|.:.|:.|        ::|..:.|  :.:.:|:.::|:.
Zfish   196 ACVNQFIISRTQALMLHIDPFIENLFA--------LAGDEEPEVRKNVCRALVMLLEV------- 245

  Fly   228 GNSNEFMGAFDIIDSMAEYVPHLLTGNVKLLLEFCLMIARNKQFDASIRVQVLTF---------- 282
                          .:...:||:..     ::|:  |:.|.:..|.::.::...|
Zfish   246 --------------RLDRLLPHMHN-----IIEY--MLQRTQDQDENVALEACEFWLTLAEQPVC 289

  Fly   283 ----VGSLVRLKKKIIMKQKLLQPTLSVL-----------------------FEVICQ-----DD 315
                .|.|.:|...::...|..:..:.:|                       ...:.|     |.
Zfish   290 KEVLCGHLPKLTPVLVNGMKYSEIDIILLKGDVEEDEAIPDNEQDIRPRFHRSRTVAQQHEGGDS 354

  Fly   316 LKEGDDD--------YFSSESLNSPSNAAAQTLDLMALHMVPDKFIPPLLDLLEPALQSPEPVLR 372
            ::|.|||        ..|..:|...|.||   ||::| ::..|..:..:|.||:..|..||.:::
Zfish   355 IEEDDDDEDDLDDDETISDWNLRKCSAAA---LDVLA-NVFRDDLLLHILPLLKELLFHPEWLIK 415

  Fly   373 RSSFICMGVIAEGCSEAIGKKYLEVMLNIIKAGVLDSVMFVRTAAFFALGQFSEFL--QPTICKF 435
            .|..:.:|.|||||.:.: ..||..::..:...:.|....||:...:.|.:::.::  ||
Zfish   416 ESGILVLGAIAEGCMQGM-IPYLPELIPHLVLCLSDKKALVRSITCWTLSRYAHWVVSQP----- 474

  Fly   436 APQILPVLFDYLNQLVLEL--KVGEPDSKHMDRMFYALETFCENLDEDIVPYLPTLMDRL----- 493
             |.      .||..|:.||  ::.:.:.:..:....|..|..|....::||||..::|.|
Zfish   475 -PD------TYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFS 532

  Fly   494 -------------FG------------------VMEP--QNSNQMRE------MALSAIAAVSAA 519
                         .|                  :|.|  |..||:::      ..|..:::|:.|
Zfish   533 KYQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNQLKDEDKDLFPLLECLSSVATA 597

  Fly   520 AKENLMPY----FPRIMTVLQGCLVK-----------DCPKEMYSQRIQAIDTLAALCRELGKDN 569
            .:...:||    :.|.:.::|..|.:           :.|.:.:  .|.|:|.|:.|...|| .|
Zfish   598 LQSGFLPYCEPVYQRCVNLVQKTLAQAVLHQNQPEYYEAPDKDF--MIVALDLLSGLAEGLG-GN 659

  Fly   570 IIPLADETMNFCLMMLEDGPDD-PEFRRS-------------------IYNLMSSLSSVVNESMA 614
            |..|...: |...:|.:...|. ||.|:|                   |.|.|..|.:.:|..:.
Zfish   660 IEQLVARS-NILTLMYQCMQDKMPEVRQSSFALLGDLTKASFQHVKPCIANFMPILGTNLNPELI 723

  Fly   615 SVFPKFIDRIME-SVISSEDMVPNVSDNAEDDLALVDAPDI-EIDLEHTDDEDDQDAYLGENDYI 677
            ||.......|.| |:....:|.|.|....:..:.:::.|:. :..||:|      ...:|...|:
Zfish   724 SVCNNATWAIGEISIQMGSEMQPYVPLVLQQLVEIINRPNTPKTLLENT------AITIGRLGYV 782

  Fly   678 VEKEEAILSLKEFATHTGAAFAPYL------------QSAFENVYKMID-HPQG---DVRMACID 726
            ..:|.|.: |::|       ..|:.            .|||..:..||. :|.|   |....| |
Zfish   783 CPQEVAPM-LQQF-------IRPWCTSLRNIRDNEEKDSAFRGICTMITVNPGGVVQDFIFFC-D 838

  Fly   727 SICS-----------FITALHKLDDAAG 743
            ::.|           |...||...:..|
Zfish   839 AVASWMNPKDDLREMFYKILHGFKNQVG 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arts	NP_001261957.1	IBN_N	29..90	CDD:197981	19/64 (30%)
		HEAT repeat	356..384	CDD:293787	9/27 (33%)
		HEAT repeat	397..427	CDD:293787	4/29 (14%)
		HEAT repeat	438..473	CDD:293787	6/36 (17%)
tnpo1	XP_021327307.1	KAP95	24..760	CDD:227540	158/806 (20%)
		HEAT repeat	129..157	CDD:293787	5/31 (16%)
		HEAT repeat	174..204	CDD:293787	5/32 (16%)
		HEAT repeat	215..241	CDD:293787	6/33 (18%)
		HEAT repeat	254..283	CDD:293787	5/35 (14%)
		HEAT repeat	404..424	CDD:293787	4/19 (21%)
		HEAT repeat	440..468	CDD:293787	4/27 (15%)
		HEAT repeat	481..511	CDD:293787	5/29 (17%)
		HEAT repeat	522..548	CDD:293787	2/25 (8%)
		HEAT repeat	563..594	CDD:293787	6/30 (20%)
		HEAT repeat	663..699	CDD:293787	8/36 (22%)
		HEAT repeat	709..739	CDD:293787	9/29 (31%)
		HEAT repeat	750..778	CDD:293787	4/33 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910