DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Arts and ipo4

DIOPT Version :9

Sequence 1:	NP_001261957.1	Gene:	Arts / 59215	FlyBaseID:	FBgn0042177	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	XP_684163.4	Gene:	ipo4 / 553305	ZFINID:	ZDB-GENE-041014-307	Length:	1085	Species:	Danio rerio

Alignment Length:	1102	Identity:	339/1102 - (30%)
Similarity:	565/1102 - (51%)	Gaps:	90/1102 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 DTERIRESTAKMLKAYENPDSLLVLTQIVMSDRPVQERQVAAVLLKRRVKKLRHWQLVPAEHQAA 80
            |...|:::||::.:|:::|..:..|..::...:..|.||.|||:|:.||:|  .|:.:..:|:.:
Zfish    16 DNAVIQQATAELKQAFKDPAIIPALCAVMTGSQNPQVRQSAAVMLRMRVRK--QWKKISPDHRES 78

  Fly    81 IKSNMLQVLIAVKEKTVKGTVAFIIGSLVRHEEDKQNSWREEILKFIYERCSSPDPIESERGSSI 145
            :|:.:||......|.||:.:::.:...||:||  ..:.| ..:|:.:.:...|.:|.:.:.|..:
Zfish    79 LKAVVLQAFQQETEHTVRHSLSQLSAVLVKHE--TPDRW-PALLELLNQSTKSNNPQDRQVGLLL 140

  Fly   146 FSSLMDAAPDQFSNHTDTIFPLLAGILVTAEANGNMATPTVHNMLAGTCVL-LPFISGHSDAEQ- 208
            .|.::.:.|:.|..|...:..|...:|      .::..||.    ...|:| |..|:.::..|:
Zfish   141 LSKVVGSNPEPFKPHYKQLLQLFGTVL------QDLNNPTA----LYYCILTLTAITAYTGTEEM 195

  Fly   209 -IMVKAVPLILKALAAF--AEKGNSNEFMGAFD-IIDS-MAEYVPHLLTGNVKLLLEFCLMIARN 268
             :|...:|.:|.||...  |::..::|.|..|| :::| ::..|||:..     ::.|||.|:.:
Zfish   196 NLMRSLIPKLLVALKHLIQADQDQASEAMEVFDELMESEVSIVVPHIAE-----IVRFCLEISAD 255

  Fly   269 KQFDASIRVQVLTFVGSLVRLKKKIIMKQKLLQPTLSVLFEVIC------QDDLKEGDDDYFSSE 327
            .....|:||:.|:.:..|:|||.|.::|.|||||.|.|:|.::.      ::|.::.::|  :..
Zfish   256 ASLSDSLRVKALSCIAVLIRLKNKAVLKHKLLQPILQVVFPILSAAPPPGEEDPEDEEND--TGG 318

  Fly   328 SLNSPSNAAAQTLDLMALHMVPDKFIPPLLDLLEPALQSPEPVLRRSSFICMGVIAEGCSEAIGK 392
            ...:|.:.|.|.:|.|||||.|:|....||...:..|.|..|..|:...:||.|:||||::.|..
Zfish   319 DSENPKHFAVQVIDTMALHMPPEKLFNQLLPFTQACLSSENPYERKGGLMCMAVLAEGCADHIRT 383

  Fly   393 KYLEVMLNIIKAGVLDSVMFVRTAAFFALGQFSEFLQPTICKFAPQILPVLFDYLNQLVLELKVG 457
            |.|..||..:...:.|:...||:||.||||||||.|||.:.||..:::|:|..||: .|.:.|:|
Zfish   384 KMLSSMLQTVCRSLSDNNQVVRSAALFALGQFSEHLQPDVSKFHAELMPLLQGYLS-AVNQTKIG 447

  Fly   458 EPDSKHMDRMFYALETFCENLDEDIVPYLPTLMDRLFGVMEPQNSNQMREMALSAIAAVSAAAKE 522
                 ||.:.|||||.|.|||.::|.||||:||:.:...:......:::|:|:|||.|::.||.|
Zfish   448 -----HMTKAFYALENFLENLGQEIEPYLPSLMETMLSALNNAEILKLKELAVSAIGAIANAATE 507

  Fly   523 NLMPYFPRIMTVLQGCLVKDCPKEMYSQRIQAIDTLAALCRELGKDNIIPLADETMNFCLMM--- 584
            .|:||||.|:..|:|.|. |..:||.:.:.||:|||:.|.|.:|||...|||.|    |:.:
Zfish   508 MLVPYFPPIIDSLKGFLT-DTREEMRALQTQALDTLSVLARTVGKDVFSPLAAE----CVQLGLN 567

  Fly   585 LEDGPDDPEFRRSIYNLMSSLSSVVNESMASVFPKFIDRIMESVISSEDMVPNVSDN-----AED 644
            |.|..|||:.||..|:|.|::|.|..:.:..........:..|:.|:|.:..::.::     .:|
Zfish   568 LTDAVDDPDLRRCTYSLFSAVSEVSPDCLTPHLTSITTVMQLSLRSTEGVTAHLDEDKQFVLLDD 632

  Fly   645 DLALVDAPDIE-----IDLEHTDDEDDQD--AYLGENDYIVEKEEAILSLKEFATHTGAAFAPYL 702
            |    ||.|.|     :|.|...:.||:|  .:..||.||.|||:|..:|.|.|.:||.||.|:|
Zfish   633 D----DADDGEEGDAILDDEGETEVDDRDVAGFSVENAYIDEKEDACDALGEIAFNTGVAFQPFL 693

  Fly   703 QSAFENVYKMIDHPQGDVRMACIDSICSFITALHKL-------DDAAGLKRACEIAIPKFAHIMR 760
            :|:|:.||.:.|.|..|||.|...::..|..|.||:       .:...|.:..|:.:|.|...::
Zfish   694 ESSFQQVYDLRDFPHEDVRKAAFGAMGQFCRAQHKVWKENPTEANHQVLHKLLEVILPCFLEAVK 758

  Fly   761 TDDQVAVVLRMLDVLYDVFKYV--PAINSQEHAELIFGCIRDIFTNKMACQFNEESGGGD--DEC 821
            .|.:..||:.:|:.:..|.|..  .|:.:......|...|:|:...|..||    ..|||  |:.
Zfish   759 QDRERQVVMAILEAMNSVIKSCQGEALQAPGRLAEISNVIKDVLKKKTVCQ----DVGGDEADDD 819

  Fly   822 SEESENDEMLFENAANLFPMFGLTLQPELFSLYFGRLYHFYIQRLAKVKERDLPEQRAYIYGALA 886
            .:::|.|.||.|.|....|.....:..|.|..:...|....   ::|.|.......|::..|.:.
Zfish   820 EQQAEFDAMLQEFAGEGIPALASAVPAETFYPHLNDLLPLI---MSKTKSSCTEADRSFSIGTIG 881

  Fly   887 DCCKAL------KGCCATYFDALRPIFIAGSRDSDAKARQNSYFALGEIVFHSEEKSFESYPTIL 945
            :...:|      :.......:.|.|:.:||.:||||:.|.||.||||.:...:.......||.:|
Zfish   882 ETLHSLVAVAGGRAVAGRLSNRLLPVLVAGVKDSDAEVRNNSVFALGALAEAAGPIIASDYPMML 946

  Fly   946 QALSEAIVRESVPAAMDNICGAVARLIVTNPDSVPLGQVLPVWLNHLPLKDDTVENDVIQKAFRV 1010
            ...|..:.:|:....:||:|.|:.|:|:::.:.|||.||.|..:..||||:|..||..|.|....
Zfish   947 SLFSNLLSKETDLRVIDNLCAALCRMIMSHIEGVPLEQVFPALVARLPLKEDMEENKTIYKCLTF 1011

  Fly  1011 LYLKARPSIEAHLEQILAITIEASYKKQMPDVETTESAVALIKEIRANYPELFSKVSNMNPE 1072
            ||......:.:.|:.|:.........|.: |.||..:.:.|::.:...:.:.|..|....|:
Zfish  1012 LYSHNPLLVVSQLKPIICAAAHLLGIKDV-DTETQNTLLILLRGLAQQHSQEFQSVVMSLPD 1072

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arts	NP_001261957.1	IBN_N	29..90	CDD:197981	18/60 (30%)
		HEAT repeat	356..384	CDD:293787	9/27 (33%)
		HEAT repeat	397..427	CDD:293787	14/29 (48%)
		HEAT repeat	438..473	CDD:293787	13/34 (38%)
ipo4	XP_684163.4	IBN_N	23..89	CDD:197981	20/67 (30%)
		KAP95	49..710	CDD:227540	235/697 (34%)
		HEAT repeat	347..375	CDD:293787	9/27 (33%)
		HEAT_EZ	360..415	CDD:290247	23/54 (43%)
		HEAT repeat	388..418	CDD:293787	14/29 (48%)
		HEAT repeat	429..458	CDD:293787	13/34 (38%)
		HEAT repeat	471..501	CDD:293787	9/29 (31%)
		HEAT_EZ	489..545	CDD:290247	26/56 (46%)
		HEAT repeat	663..685	CDD:293787	11/21 (52%)
		HEAT repeat	695..739	CDD:293787	14/43 (33%)
		HEAT repeat	748..775	CDD:293787	6/26 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592221
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2171
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5835
Inparanoid	1	1.050	466	1.000	Inparanoid score	I1508
OMA	1	1.010	-	-		QHG54177
OrthoDB	1	1.010	-	-		D331433at2759
OrthoFinder	1	1.000	-	-		FOG0005113
OrthoInspector	1	1.000	-	-		otm26144
orthoMCL	1	0.900	-	-		OOG6_102877
Panther	1	1.100	-	-	O	PTHR10527
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R603
SonicParanoid	1	1.000	-	-		X4732
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800